Pig to rat cell transplantation: reduced cellular and antibody responses to xenografts overexpressing PD-L1

An Effective Approach to Prevent Immune Rejection of Human ESC-Derived Allografts

(2014) Zhili Rong et al.   Cell Stem Cell

Allorecognition Pathways in Transplant Rejection and Tolerance

(2013) Jason M. Ali et al.   TRANSPLANTATION

ITIM-dependent negative signaling pathways for the control of cell-mediated xenogeneic immune responses

(2013) Maria-Luisa del Rio et al.   XENOTRANSPLANTATION

PD-1 is a novel regulator of human B-cell activation

(2012) Marie-Laure Thibult et al.   INTERNATIONAL IMMUNOLOGY

Costimulation Blockade

(2012) Gillian Kinnear et al.   TRANSPLANTATION

First inducible transgene expression in porcine large animal models

(2011) Nikolai Klymiuk et al.   FASEB JOURNAL

Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules

(2011) Tadatsura Koshika et al.   IMMUNOLOGY

Programmed Cell Death 1 Suppresses B-1b Cell Expansion and Long-Lived IgG Production in Response to T Cell-Independent Type 2 Antigens

(2011) Karen M. Haas   JOURNAL OF IMMUNOLOGY

Human PD-L1-overexpressing porcine vascular endothelial cells induce functionally suppressive human CD4+CD25hiFoxp3+ Treg cells

(2011) Q. Ding et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

(2010) Elissa K. Deenick et al.   IMMUNITY

Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques

(2010) Kehmia Titanji et al.   JOURNAL OF CLINICAL INVESTIGATION

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Downregulation of cytolytic activity of human effector cells by transgenic expression of human PD-ligand-1 on porcine target cells

(2010) Annegret Plege et al.   TRANSPLANT INTERNATIONAL

Programmed death-1 receptor negatively regulates LPS-mediated IL-12 production and differentiation of murine macrophage RAW264.7 cells

(2009) Hae-Yun Cho et al.   IMMUNOLOGY LETTERS

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Human T-Cell Activation and Expansion of Regulatory T Cells by Pig Cells Overexpressing PD-Ligands

(2009) Annegret Plege et al.   TRANSPLANTATION

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current cellular immunological hurdles in pig-to-primate xenotransplantation

(2008) Stéphanie Le Bas-Bernardet et al.   TRANSPLANT IMMUNOLOGY