Towards a universal influenza vaccine: different approaches for one goal

Human monoclonal antibodies neutralizing influenza virus A/H1N1pdm09 and seasonal A/H1N1 strains – Distinct Ig gene repertoires with a similar action mechanism

(2018) Satoshi Hiroi et al.   IMMUNOBIOLOGY

Predictive Modeling of Influenza Shows the Promise of Applied Evolutionary Biology

(2018) Dylan H. Morris et al.   TRENDS IN MICROBIOLOGY

Infection of Ferrets with Influenza Virus Elicits a Light Chain–Biased Antibody Response against Hemagglutinin

(2017) Greg A. Kirchenbaum et al.   JOURNAL OF IMMUNOLOGY

The Doctrine of Original Antigenic Sin: Separating Good From Evil

(2017) Arnold S. Monto et al.   JOURNAL OF INFECTIOUS DISEASES

Elicitation of Protective Antibodies against a Broad Panel of H1N1 Viruses in Ferrets Preimmune to Historical H1N1 Influenza Viruses

(2017) Donald M. Carter et al.   JOURNAL OF VIROLOGY

Computationally Optimized Broadly Reactive Hemagglutinin Elicits Hemagglutination Inhibition Antibodies against a Panel of H3N2 Influenza Virus Cocirculating Variants

(2017) Terianne M. Wong et al.   JOURNAL OF VIROLOGY

Highly conserved M2e and hemagglutinin epitope-based recombinant proteins induce protection against influenza virus infection

(2017) Yan Guo et al.   MICROBES AND INFECTION

Internal image anti-idiotypic antibody: A new strategy for the development a new category of prolactin receptor (PRLR) antagonist

(2017) Hainan Lan et al.   MOLECULAR IMMUNOLOGY

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

(2017) Eva-Maria Strauch et al.   NATURE BIOTECHNOLOGY

Back to the future: Immunization with M-001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain

(2017) George H. Lowell et al.   VACCINE

New Insights for Immune-Based Diagnosis and Therapy for Infectious Diseases

(2017) Giuseppe A. Sautto et al.   Journal of Immunology Research

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

(2017) Raffael Nachbagauer et al.   npj Vaccines

Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains

(2017) Ivette A. Nuñez et al.   PLoS One

A Biologically-validated HCV E1E2 Heterodimer Structural Model

(2017) Matteo Castelli et al.   Scientific Reports

An influenza A virus (H7N9) anti-neuraminidase monoclonal antibody with prophylactic and therapeutic activity in vivo

(2016) Jason R. Wilson et al.   ANTIVIRAL RESEARCH

Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses

(2016) Donald M. Carter et al.   JOURNAL OF VIROLOGY

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

(2016) Jiwon Lee et al.   NATURE MEDICINE

Development of high-yield influenza B virus vaccine viruses

(2016) Jihui Ping et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cross-reactive mucosal T and B cell responses in human nasopharynx-associated lymphoid tissue in vitro by Modified Vaccinia Ankara-vectored influenza vaccines

(2016) Jennifer Mullin et al.   VACCINE

Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza

(2016) Veronika I. Zarnitsyna et al.   PLoS Pathogens

Stalking influenza by vaccination with pre-fusion headless HA mini-stem

(2016) Sophie A. Valkenburg et al.   Scientific Reports

An avian influenza A (H7N9) virus vaccine candidate based on the fusion protein of hemagglutinin globular head and Salmonella typhimurium flagellin

(2015) Li Song et al.   BMC BIOTECHNOLOGY

Use of computational and recombinant technologies for developing novel influenza vaccines

(2015) Terianne M Wong et al.   Expert Review of Vaccines

Flucelvax (Optaflu) for seasonal influenza

(2015) Ilaria Manini et al.   Expert Review of Vaccines

Sequential Infection in Ferrets with Antigenically Distinct Seasonal H1N1 Influenza Viruses Boosts Hemagglutinin Stalk-Specific Antibodies

(2015) Greg A. Kirchenbaum et al.   JOURNAL OF VIROLOGY

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Virus-induced preferential antibody gene-usage and its importance in humoral autoimmunity

(2015) Francesca Cappelletti et al.   SEMINARS IN IMMUNOLOGY

Cross-protection against H7N9 influenza strains using a live-attenuated H7N3 virus vaccine

(2015) Donald M. Carter et al.   VACCINE

Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014–2015 Influenza Season

(2015) Benjamin S. Chambers et al.   Cell Reports

Cocktail of H5N1 COBRA HA vaccines elicit protective antibodies against H5N1 viruses from multiple clades

(2015) Corey J Crevar et al.   Human Vaccines & Immunotherapeutics

Hemagglutinin Sequence Conservation Guided Stem Immunogen Design from Influenza A H3 Subtype

(2015) V. Vamsee Aditya Mallajosyula et al.   Frontiers in Immunology

A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells

(2015) Venkateswara R. Simhadri et al.   PLoS One

An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein

(2015) Aerin Yoon et al.   PLoS One

Eliciting broadly protective antibody responses against influenza

(2014) Greg A Kirchenbaum et al.   CURRENT OPINION IN IMMUNOLOGY

Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1)

(2014) G S Freidl et al.   Eurosurveillance

Effects of Aging on Influenza Virus Infection Dynamics

(2014) E. A. Hernandez-Vargas et al.   JOURNAL OF VIROLOGY

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

(2014) J. R. R. Whittle et al.   JOURNAL OF VIROLOGY

Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection

(2014) V. V. A. Mallajosyula et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

(2014) A. H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bat-derived influenza-like viruses H17N10 and H18N11

(2014) Ying Wu et al.   TRENDS IN MICROBIOLOGY

Priming by a novel universal influenza vaccine (Multimeric-001)—A gateway for improving immune response in the elderly population

(2014) Jacob Atsmon et al.   VACCINE

Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family

(2014) B. M. Hause et al.   mBio

Influence of pre-existing hemagglutination inhibition titers against historical influenza strains on antibody response to inactivated trivalent influenza vaccine in adults 50–80 years of age

(2014) Ted M Ross et al.   Human Vaccines & Immunotherapeutics

Peptide-Based Vaccinology: Experimental and Computational Approaches to Target Hypervariable Viruses through the Fine Characterization of Protective Epitopes Recognized by Monoclonal Antibodies and the Identification of T-Cell-Activating Peptides

(2013) Matteo Castelli et al.   Clinical & Developmental Immunology

Guiding the Immune Response against Influenza Virus Hemagglutinin toward the Conserved Stalk Domain by Hyperglycosylation of the Globular Head Domain

(2013) D. Eggink et al.   JOURNAL OF VIROLOGY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion and Enhance Influenza Virus Respiratory Disease

(2013) S. Khurana et al.   Science Translational Medicine

Human Germline Antibody Gene Segments Encode Polyspecific Antibodies

(2013) Jordan R. Willis et al.   PLoS Computational Biology

HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role

(2012) Giuseppe Sautto et al.   Clinical & Developmental Immunology

A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection

(2012) Brendan M. Giles et al.   JOURNAL OF INFECTIOUS DISEASES

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses

(2012) N. Pica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?

(2012) Mancini Nicasio et al.   Viruses-Basel

Molecular Signatures of Hepatitis C Virus (HCV)-Induced Type II Mixed Cryoglobulinemia (MCII)

(2012) Giuseppe Sautto et al.   Viruses-Basel

A potential role for monoclonal antibodies in prophylactic and therapeutic treatment of influenza

(2011) Nicasio Mancini et al.   ANTIVIRAL RESEARCH

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

(2011) Sanae Sasaki et al.   JOURNAL OF CLINICAL INVESTIGATION

A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets

(2011) Brendan M. Giles et al.   VACCINE

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret

(2010) Srinivas S. Rao et al.   PLoS One

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

(2010) C.-J. Wei et al.   SCIENCE

Vaccines with MF59 Adjuvant Expand the Antibody Repertoire to Target Protective Sites of Pandemic Avian H5N1 Influenza Virus

(2010) S. Khurana et al.   Science Translational Medicine

Seasonal influenza and vaccination coverage

(2010) Arnold S. Monto   VACCINE

Monoclonal antibodies isolated from human B cells neutralize a broad range of H1 subtype influenza A viruses including swine-origin Influenza virus (S-OIV)

(2010) Roberto Burioni et al.   VIROLOGY

HIV-1 and influenza antibodies: seeing antigens in new ways

(2009) Peter D Kwong et al.   NATURE IMMUNOLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

A universal epitope-based influenza vaccine and its efficacy against H5N1

(2009) Y. Adar et al.   VACCINE

Influenza vaccines

(2009) A.H. Ellebedy et al.   VACCINE

Influence of Prior Influenza Vaccination on Antibody and B-Cell Responses

(2008) Sanae Sasaki et al.   PLoS One

Anti-HIV-1 Response Elicited in Rabbits by Anti-Idiotype Monoclonal Antibodies Mimicking the CD4-Binding Site

(2008) Roberto Burioni et al.   PLoS One

Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: Cold-adapted vaccine versus DNA prime-adenovirus boost strategies

(2008) Chia-Yun Lo et al.   VACCINE