期刊
EXPERT REVIEW OF VACCINES
卷 15, 期 1, 页码 41-51出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2016.1113877
关键词
vaccine; influenza; bioinformatics; computational approaches
类别
Influenza vaccine design has changed considerably with advancements in bioinformatics and computational biology. Improved surveillance efforts provide up-to-date information about influenza sequence diversity and assist with monitoring the spread of epidemics and vaccine efficacy rates. The advent of next-generation sequencing, epitope scanning and high-throughput analysis all help decipher influenza-associated protein interactions as well as predict immune responsiveness based on host genetic diversity. Computational approaches are utilized in nearly all aspects of vaccine design, from modeling, compatibility predictions, and optimization of antigens in various platforms. This overview discusses how computational techniques strengthen vaccine efforts against highly diverse influenza species.
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