Article
Multidisciplinary Sciences
Pavlos Anastasiadis, Dheeraj Gandhi, Yutong Guo, Abdul-Kareem Ahmed, Soren M. Bentzen, Costas Arvanitis, Graeme F. Woodworth
Summary: This study evaluates the safety and utility of microbubble-enhanced focused ultrasound for spatially targeted blood-brain barrier opening in patients with infiltrating gliomas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Dennison Trinh, Joanne Nash, David Goertz, Kullervo Hynynen, Sharsi Bulner, Umar Iqbal, James Keenan
Summary: The study demonstrates the effective delivery of viral vector gene therapies to brain regions affected in Parkinson's disease (PD) using MR-guided focused ultrasound (MR-g-FUS) and microbubble drug conjugates (MDCs). This technology shows potential as a disease-modifying strategy in PD and other neurodegenerative disorders.
Review
Pharmacology & Pharmacy
Ko-Ting Chen, Kuo-Chen Wei, Hao-Li Liu
Summary: Focused ultrasound combined with microbubbles enables precise, transient, reversible, and noninvasive opening of the blood-brain barrier. This technology enhances the penetration of therapeutic agents in the central nervous system, while also modulating local immunity and neuronal activity.
Article
Pharmacology & Pharmacy
Payton Martinez, Nick Bottenus, Mark Borden
Summary: This study aimed to explore the acoustic response of different microbubble sizes and concentrations. The results showed that the onset of harmonic cavitation and broadband cavitation dose depended on the mechanical index, microbubble size, and microbubble concentration. Furthermore, when microbubble size and concentration were combined into gas volume fraction, all different microbubble size distributions aligned to similar onset and peak.
Article
Acoustics
Tereza Alekou, Marinos Giannakou, Christakis Damianou
Summary: A high intensity focused ultrasound phantom model was developed for experiments on Blood Brain Barrier disruption. The model successfully simulated BBB disruption during ultrasound application and has the potential to be a cost-effective alternative to animal experiments.
Article
Pharmacology & Pharmacy
Yu-Hone Hsu, Wei-Chung Lee, Shing-Shung Chu, Meng-En Chao, Kuo-Sheng Wu, Ren-Shyan Liu, Tai-Tong Wong
Summary: Pulsed ultrasound combined with microbubbles can temporarily disrupt the blood-brain barrier (BBB) and open a temporal window for delivering large therapeutic molecules into brain tissue. This study investigates the effects of different sonication parameters, time, and microbubble dose on BBB disruption, as well as the dynamics of BBB disruption and the efficacy of different sonication schemes. The results show that pulsed weakly focused ultrasound can extensively and reversibly open the BBB with limited brain tissue damage.
Article
Chemistry, Multidisciplinary
Sophie Morse, Aishwarya Mishra, Tiffany G. Chan, Rafael T. M. de Rosales, James J. Choi
Summary: The study investigates a noninvasive method of using ultrasound pulses to deliver liposomes across the blood-brain barrier for efficient drug delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, Research & Experimental
Charissa Poon, Carly Pellow, Kullervo Hynynen
Summary: The study demonstrates that transcranial focused ultrasound with microbubbles treatments can induce acute inflammatory responses involving neutrophils, though multiple treatments do not significantly increase neutrophil recruitment or phagocytosis of beta-amyloid plaques in an Alzheimer's disease mouse model. Further investigations into leukocyte dynamics and cerebral blood flow responses to these treatments are needed.
Article
Medicine, Research & Experimental
Liyu Chen, Ratneswary Sutharsan, Jonathan L. F. Lee, Esteban Cruz, Blaise Asnicar, Tishila Palliyaguru, Joanna M. Wasielewska, Arnaud Gaudin, Jae Song, Gerhard Leinenga, Jurgen Gotz
Summary: Focused ultrasound (FUS) combined with intravenously injected microbubbles (FUS+MB) can open the blood-brain barrier, allowing therapeutic agents to enter the brain. By combining different modalities, it is possible to lower the acoustic pressure and improve treatment outcomes.
Article
Engineering, Biomedical
Maria Eleni Karakatsani, Antonios N. Pouliopoulos, Michael Liu, Sachin R. Jambawalikar, Elisa E. Konofagou
Summary: The study investigated the use of diffusion tensor imaging for detecting focused ultrasound-induced blood-brain barrier opening, showing an increase in fractional anisotropy and diffusion anisotropy enhancement post-BBB opening. The experiment confirmed the feasibility of the technique and suggested its potential as a contrast-free MRI modality for evaluating BBB integrity in brain-related pathologies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Koki Ogawa, Naoya Kato, Michiharu Yoshida, Takeshi Hiu, Takayuki Matsuo, Shusaku Mizukami, Daiki Omata, Ryo Suzuki, Kazuo Maruyama, Hidefumi Mukai, Shigeru Kawakami
Summary: This study investigated the use of microbubble-assisted focused ultrasound blood-brain barrier opening for the intravenous delivery of mRNA-LNP. The results showed that exogenous protein expression by mRNA-LNP occurred only when FUS and microbubbles were applied to the brain.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Paul Wrede, Amirreza Aghakhani, Ugur Bozuyuk, Erdost Yildiz, Metin Sitti
Summary: Microparticle manipulation and trapping are crucial in biotechnology. This study proposes the use of hollow borosilicate microparticles and a single-lens focused ultrasound (FUS) transducer for effective manipulation. The method proves effective under realistic flow rates and ultrasound amplitudes and has potential biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Pharmacology & Pharmacy
Sheng-Kai Wu, Chia-Lin Tsai, Yuexi Huang, Kullervo Hynynen
Summary: The presence of blood-brain barriers is a major obstacle in effectively delivering therapeutics to the central nervous system, especially in treating malignant brain tumors. Conventional methods have not been successful, but techniques like convention-enhanced delivery and focused ultrasound show promise in overcoming this challenge.
Article
Acoustics
Marieke Olsman, Viktoria Sereti, Melina Muhlenpfordt, Kasper Bendix Johnsen, Thomas Lars Andresen, Andrew James Urquhart, Catharina De Lange Davies
Summary: Research shows that combining FUS and microbubbles with BBB-targeting liposomes can enhance drug delivery to the brain. Transferrin receptor-targeting liposomes exhibited increased accumulation in the FUS-treated hemisphere, while isotype immunoglobulin G liposomes did not show significant increase.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Review
Engineering, Biomedical
Paul Mondou, Sebastien Meriaux, Florent Nageotte, Jonathan Vappou, Anthony Novell, Benoit Larrat
Summary: This review summarizes the current state of in vitro and in vivo cavitation control algorithms for blood-brain barrier (BBB) permeabilization using microbubbles (MB) and focused ultrasound (FUS). It describes the different cavitation states, the indexes used for ultrasonic monitoring, and the various control strategies for BBB permeabilization.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Acoustics
N. Hosseinkhah, H. Chen, T. J. Matula, P. N. Burns, K. Hynynen
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2013)
Article
Engineering, Biomedical
N. Hosseinkhah, K. Hynynen
PHYSICS IN MEDICINE AND BIOLOGY
(2012)
Review
Health Care Sciences & Services
Pooyeh Graili, Luciano Ieraci, Nazanin Hosseinkhah, Mary Argent-Katwala
Summary: Despite the number of systematic reviews on the application of artificial intelligence in various medical fields, there has been no study on the use of artificial intelligence methods in outcomes research, a crucial aspect of health technology assessment (HTA). This systematic scoping review aimed to capture and analyze the range of artificial intelligence methods used in outcomes research. The review identified a total of 370 studies focusing on adult patients undergoing medical interventions and reporting therapeutic, preventive, or prognostic outcomes. The review found that artificial intelligence was mainly used for predicting more frequently reported outcomes, particularly in neoplastic disorders, with neural networks algorithms being commonly used in surgical studies. However, there were variations in the use of artificial intelligence algorithms across different medical interventions, highlighting the need for further considerations by decision-makers before incorporating artificial intelligence into HTA decision-making processes.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2021)