Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain
出版年份 2022 全文链接
标题
Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain
作者
关键词
-
出版物
JOURNAL OF CONTROLLED RELEASE
Volume 348, Issue -, Pages 34-41
出版商
Elsevier BV
发表日期
2022-06-01
DOI
10.1016/j.jconrel.2022.05.042
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics
- (2022) Hidefumi Mukai et al. Drug Metabolism and Pharmacokinetics
- Size‐Selective Transfer of Lipid Nanoparticle‐Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury
- (2022) Igor Khalin et al. Small
- Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle
- (2021) Yuta Fukushima et al. BIOMATERIALS
- Suppression of Peritoneal Fibrosis by Sonoporation of Hepatocyte Growth Factor Gene-Encoding Plasmid DNA in Mice
- (2021) Koyo Nishimura et al. Pharmaceutics
- Nanomaterial Delivery Systems for mRNA Vaccines
- (2021) Michael D. Buschmann et al. Vaccines
- Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles
- (2021) Federica Sebastiani et al. ACS Nano
- Efficient Messenger RNA Delivery to the Kidney Using Renal Pelvis Injection in Mice
- (2021) Natsuko Oyama et al. Pharmaceutics
- Improved Stability of siRNA-Loaded Lipid Nanoparticles Prepared with a PEG-Monoacyl Fatty Acid Facilitates Ligand-Mediated siRNA Delivery
- (2020) Yu Sakurai et al. MOLECULAR PHARMACEUTICS
- Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
- (2020) Oscar A. Marcos-Contreras et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of Tissue Pressure on Transgene Expression Characteristics via Renal Local Administration Routes from Ureter or Renal Artery in the Rat Kidney
- (2020) Natsuko Oyama et al. Pharmaceutics
- Lipid and Lipoprotein Metabolism in Microglia
- (2020) Bailey A. Loving et al. Frontiers in Physiology
- Lipid nanoparticle technology for therapeutic gene regulation in the liver
- (2020) Dominik Witzigmann et al. ADVANCED DRUG DELIVERY REVIEWS
- Recent Strategies for Targeted Brain Drug Delivery
- (2020) Koki Ogawa et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection
- (2020) Feihe Ma et al. Science Advances
- Investigating the optimum size of nanoparticles for their delivery into the brain assisted by focused ultrasound-induced blood–brain barrier opening
- (2020) Seiichi Ohta et al. Scientific Reports
- Synthetic mRNA Encoding VEGF-A in Patients Undergoing Coronary Artery Bypass Grafting: Design of a Phase 2a Clinical Trial
- (2020) Vesa Anttila et al. Molecular Therapy-Methods & Clinical Development
- Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
- (2019) Li-Ming Gan et al. Nature Communications
- Ultrasound-responsive nanobubble-mediated gene transfection in the cerebroventricular region by intracerebroventricular administration in mice
- (2019) Koki Ogawa et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Effects of encapsulated gas on stability of lipid-based microbubbles and ultrasound-triggered drug delivery
- (2019) Daiki Omata et al. JOURNAL OF CONTROLLED RELEASE
- First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
- (2019) Agessandro Abrahao et al. Nature Communications
- Efficient gene transfection to the brain with ultrasound irradiation in mice using stabilized bubble lipopolyplexes prepared by the surface charge regulation method
- (2018) Koki Ogawa et al. International Journal of Nanomedicine
- In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration
- (2018) Hiroki Tanaka et al. MOLECULAR PHARMACEUTICS
- Focused ultrasound–mediated noninvasive blood-brain barrier modulation: preclinical examination of efficacy and safety in various sonication parameters
- (2018) Jaewoo Shin et al. Neurosurgical Focus
- Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
- (2018) Nir Lipsman et al. Nature Communications
- PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
- (2018) Hamideh Parhiz et al. JOURNAL OF CONTROLLED RELEASE
- Evaluation of the targeted delivery of 5-fluorouracil and ascorbic acid into the brain with ultrasound-responsive nanobubbles
- (2017) Yusuke Miura et al. JOURNAL OF DRUG TARGETING
- Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound
- (2016) Brian P. Mead et al. JOURNAL OF CONTROLLED RELEASE
- Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
- (2016) Lena M. Kranz et al. NATURE
- Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation
- (2016) Zsofia I. Kovacs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors
- (2016) Ching-Hsiang Fan et al. Theranostics
- Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging
- (2016) Po-Chun Chu et al. Scientific Reports
- Ultrasound and microbubble mediated drug delivery: Acoustic pressure as determinant for uptake via membrane pores or endocytosis
- (2015) Ine De Cock et al. JOURNAL OF CONTROLLED RELEASE
- Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system
- (2014) Muna Aryal et al. ADVANCED DRUG DELIVERY REVIEWS
- A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines
- (2014) Luis A Brito et al. MOLECULAR THERAPY
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Submicron-Bubble-Enhanced Focused Ultrasound for Blood–Brain Barrier Disruption and Improved CNS Drug Delivery
- (2014) Ching-Hsiang Fan et al. PLoS One
- Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles
- (2013) Barbara L Mui et al. Molecular Therapy-Nucleic Acids
- Dynamic Study of Blood–Brain Barrier Closure after its Disruption using Ultrasound: A Quantitative Analysis
- (2012) Benjamin Marty et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Mechanism of Low-Frequency Ultrasound in Opening Blood–Tumor Barrier by Tight Junction
- (2010) Xiuli Shang et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started