Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop

From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home

(2017) Margaret M. Harnett et al.   Biomedical Journal

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterizing “Adversity” of Pathology Findings in Nonclinical Toxicity Studies

(2016) Xavier Palazzi et al.   TOXICOLOGIC PATHOLOGY

Comparative Renal Toxicopathology of Antisense Oligonucleotides

(2016) Jeffery A. Engelhardt   Nucleic Acid Therapeutics

Cellular uptake and intracellular trafficking of oligonucleotides

(2015) R.L. Juliano et al.   ADVANCED DRUG DELIVERY REVIEWS

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Scientific and Regulatory Policy Committee Points-to-consider Paper*

(2015) Jeffery A. Engelhardt et al.   TOXICOLOGIC PATHOLOGY

PEGylated Biopharmaceuticals

(2015) Inge A. Ivens et al.   TOXICOLOGIC PATHOLOGY

Scientific and Regulatory Policy Committee

(2015) Roy Kerlin et al.   TOXICOLOGIC PATHOLOGY

Contribution of Membrane Trafficking Perturbation to Retinal Toxicity

(2015) Su Khoh-Reiter et al.   TOXICOLOGICAL SCIENCES

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

(2014) Andreas Baumann et al.   DRUG DISCOVERY TODAY

Glucosylceramide and Lysophosphatidylcholines as Potential Blood Biomarkers for Drug-Induced Hepatic Phospholipidosis

(2014) Kosuke Saito et al.   TOXICOLOGICAL SCIENCES

Are hERG channel blockers also phospholipidosis inducers?

(2013) Hongmao Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery

(2013) György T. Balogh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Modeling Phospholipidosis Induction: Reliability and Warnings

(2013) Laura Goracci et al.   Journal of Chemical Information and Modeling

Complex Histopathologic Response in Rat Kidney to Oral β-myrcene

(2013) Mark F. Cesta et al.   TOXICOLOGIC PATHOLOGY

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Lipofuscin: formation, effects and role of macroautophagy

(2013) Annika Höhn et al.   Redox Biology

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications

(2012) Randall Logan et al.   Expert Opinion on Drug Metabolism & Toxicology

Comparison of the Diagnostic Accuracy of Di-22:6-Bis(monoacylglycerol)Phosphate and Other Urinary Phospholipids for Drug-Induced Phospholipidosis or Tissue Injury in the Rat

(2012) Karol L. Thompson et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

(2012) Kendall S. Frazier et al.   TOXICOLOGIC PATHOLOGY

Lysosomal Function and Dysfunction: Mechanism and Disease

(2011) Patricia Boya   ANTIOXIDANTS & REDOX SIGNALING

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

The role of lysosomes in iron metabolism and recycling

(2011) Tino Kurz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Administration, distribution, metabolism and elimination of polymer therapeutics

(2011) Ela Markovsky et al.   JOURNAL OF CONTROLLED RELEASE

In Silico Assay for Assessing Phospholipidosis Potential of Small Druglike Molecules: Training, Validation, and Refinement Using Several Data Sets

(2011) Holger Fischer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stat3 controls lysosomal-mediated cell death in vivo

(2011) Peter A. Kreuzaler et al.   NATURE CELL BIOLOGY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

Pathophysiology of neuropathic lysosomal storage disorders

(2010) Cinzia Maria Bellettato et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Predicting Phospholipidosis Using Machine Learning

(2010) Robert Lowe et al.   MOLECULAR PHARMACEUTICS

Amphiphile regulation of ion channel function by changes in the bilayer spring constant

(2010) J. A. Lundbaek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?

(2009) Boris Turk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Drug-induced phospholipidosis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes

(2008) Kazuhiko Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysosomal involvement in cell death and cancer

(2008) Thomas Kirkegaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Testing Human Biologicals in Animal Host Resistance Models

(2008) Gary R. Burleson et al.   Journal of Immunotoxicology

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

Autophagy Is Essential for Preimplantation Development of Mouse Embryos

(2008) S. Tsukamoto et al.   SCIENCE

Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models

(2008) Naomi L. Kruhlak et al.   TOXICOLOGY MECHANISMS AND METHODS

Drug-induced Phospholipidosis -Pathological Aspects and Its Prediction

(2008) Takashi Nonoyama et al.   Journal of Toxicologic Pathology