Article
Biochemistry & Molecular Biology
Aline Almeida da Silva, Elisangela Martins da Silva Perez, Ingrid Samantha Tavares de Figueiredo, Nylane Maria Nunes de Alencar, Ana Paula Negreiros Nunes Alves, Fabiano Andre Narciso Fernandes, Renata Prado Vasconcelos, Ariclecio Cunha de Oliveira, Socorro Vanesca Frota Gaban
Summary: This study investigated the effects of virgin coconut oil (VCO) on body weight, white fat depots, and biochemical and morphological parameters in male Swiss mice fed standard (SD) or high-fat (HFD) diets. The results showed that low-dose VCO supplementation did not improve obesity, had no effects on hepatic or renal function, and had beneficial effects on the lipid profile only in animals fed HFD.
Article
Cell Biology
Vincent Dani, Solene Bruni-Favier, Berengere Chignon-Sicard, Agnes Loubat, Alain Doglio, Christian Dani
Summary: This study introduces a novel adipose tissue model, ExAdEx, which can be used to investigate the regulation of adipose progenitor cell (APC) subpopulation expansion in lean and obese adipose tissue microenvironments. The results show that inflammatory and fibrotic microenvironments differentially regulate the expansion of CD26 APC subpopulation and its progenies.
Article
Medicine, Research & Experimental
Chaowei Li, Qi Chen, Yanrong Liu, Zhuwen Sun, Zhentong Shen, Shuhan Li, Dingrui Cha, Chao Sun
Summary: In this study, it was found that MetEnk effectively prevented obesity and improved glucose tolerance and insulin sensitivity. It also improved mitochondrial function, promoted lipolysis and thermogenesis through the activation of the cAMP/PKA pathway.
Article
Chemistry, Multidisciplinary
Ana Maria Gracioso Martins, Michael D. Wilkins, Frances S. Ligler, Michael A. Daniele, Donald O. Freytes
Summary: The study proposes an inexpensive, versatile, high-throughput platform for measuring the contraction of microtissues by embedding optical fiber microprobes. This platform accurately quantifies positional changes in optical microprobes and can be used for high-throughput screening of microtissues in disease modeling, drug screening, physiology research, and safety pharmacology.
Review
Biochemistry & Molecular Biology
J. Michael Sorrell, Arnold Caplan
Summary: White adipose tissues are crucial endocrine organs that release adipokines, affecting other major organ systems. The development and functions of adipose tissues rely heavily on the glycosaminoglycan heparan sulfate, which regulates cellular physiology and communication. Understanding the role of heparan sulfates in the regulation of adipokine production and release could provide valuable insights into tissue engineering and experimental studies.
Editorial Material
Endocrinology & Metabolism
Imke L. Lemmer, Alexander Bartelt
Summary: An elegant quantitative analysis of brown fat and skeletal muscle metabolite flux reveals that brown fat predominantly uses glucose and lactate and acts as a nitrogen scavenger during thermogenesis.
Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Endocrinology & Metabolism
Sebastian Moller Nguyen Heimburger, Bjorn Hoe, Chris Neumann Nielsen, Natasha Chidekel Bergman, Kirsa Skov-Jeppesen, Bolette Hartmann, Jens Juul Holst, Flemming Dela, Julie Overgaard, Joachim Storling, Tina Vilsboll, Thomas Fremming Dejgaard, Jesper Foged Havelund, Vladimir Gorshkov, Frank Kjeldsen, Nils Joakim Faergeman, Martin Ronn Madsen, Mikkel B. Christensen, Filip Krag Knop
Summary: In men with type 1 diabetes, a 6-day subcutaneous GIP infusion transiently decreased bone resorption and increased NEFA and beta-oxidation. Further, hepatic fat content and supraclavicular skin temperature were increased without affecting WAT transcriptomics, the circulating proteome, lipids, or inflammatory markers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Plant Sciences
Ra-Yeong Choi, Mi-Kyung Lee
Summary: The study demonstrated that the Polygonum multiflorum Thunb. hot water extract had an anti-obesity effect in high-fat diet-induced obese mice by suppressing lipogenesis in white adipose tissue, leading to normalization of lipid metabolism in brown adipose tissue.
Article
Endocrinology & Metabolism
Alana Deutsch, Kosaku Shinoda
Summary: Studies have shown that prolonged exposure to cold can increase the thermogenic capacity of brown adipose tissue through the recruitment of new brown adipocytes. Shamsi et al. and Angueira et al. have identified novel cellular origins of cold-induced brown adipocytes and elucidated the molecular mechanism regulating the expansion of brown adipose tissue.
Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Article
Engineering, Biomedical
Kendall P. Murphy, Michael A. Hendley, Alexandra T. Patterson, Hayley E. Hall, Griffin J. Carter, Christopher Isely, R. Michael Gower
Summary: This study demonstrated that implanting resveratrol-releasing poly(lactide-co-glycolide) scaffolds into adipose tissue can effectively reduce adipocyte size and aid in weight control in lean mice by enhancing lipid catabolism. The scaffold-based strategy only requires a single administration, making it more convenient compared to daily oral doses.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Chemistry, Multidisciplinary
Lin Qi, Peter-James H. Zushin, Ching-Fang Chang, Yue Tung Lee, Diana L. Alba, Suneil K. Koliwad, Andreas Stahl
Summary: The study successfully utilized human stem cells to derive metabolically functional 3D adipose tissue in a microphysiological system (MPS), providing a potential for new drug discovery. Through optimization of new differentiation conditions, hormonally responsive adipose tissue was obtained, showing significantly improved insulin responsiveness and fatty acid uptake compared to previous methods.
Article
Biochemistry & Molecular Biology
Yu Li, Dongmei Wang, Xiaodan Ping, Yankang Zhang, Ting Zhang, Li Wang, Li Jin, Wenjun Zhao, Mingwei Guo, Fei Shen, Meiyao Meng, Xin Chen, Ying Zheng, Jiqiu Wang, Dali Li, Qiang Zhang, Cheng Hu, Lingyan Xu, Xinran Ma
Summary: This study discovered that local hyperthermia therapy promotes the activation of beige fat and offers a promising strategy against obesity via the HSF1-A2B1 transcriptional axis.
Article
Multidisciplinary Sciences
Iokfai Cheang, Xu Zhu, Xin Yue, Yuan Tang, Yujie Gao, Xinyi Lu, Shi Shi, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yinsu Zhu, Yi Xu, Xinli Li
Summary: The purpose of this study was to investigate the prognostic values of ventricle epicardial fat volume (EFV) in patients with chronic heart failure (CHF) using cardiac magnetic resonance. A total of 516 CHF patients were recruited, and 136 (26.4%) of them experienced major adverse cardiovascular events (MACE) within a median follow-up of 24 months. The study found that EFV was significantly associated with MACE and showed promising predictive ability for MACE at different time points.
Article
Biochemistry & Molecular Biology
Ye Tian, Wen Yuan, Jun Li, Hua Wang, Maxwell G. Hunt, Chao Liu, Irving M. Shapiro, Makarand V. Risbud
Article
Multidisciplinary Sciences
Steven D. Scahill, Maxwell Hunt, Camille L. Rogers, Frank H. Lau
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Cardiac & Cardiovascular Systems
Mary A. Siki, Andreas Habertheuer, Joseph E. Bavaria, Caroline Komlo, Maxwell Hunt, Melanie A. Freas, Rita K. Milewski, Nimesh D. Desai, Wilson Y. Szeto, Prashanth Vallabhajosyula
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Biochemistry & Molecular Biology
Kathryn R. Brink, Maxwell G. Hunt, Andrew M. Mu, Ken Groszman, Ky V. Hoang, Kevin P. Lorch, Brett H. Pogostin, John S. Gunn, Jeffrey J. Tabor
Summary: In this study, a display method was developed to investigate the effects of human antimicrobial peptides (AMPs) on the pathogenesis-regulating TCS PhoPQ of Salmonella Typhimurium. The study found that PhoPQ can sense AMPs with diverse sequences, structures, and biological functions. Machine learning was used to identify peptide sub-domains and biophysical features linked to PhoPQ activation.
NATURE CHEMICAL BIOLOGY
(2023)
