Article
Chemistry, Multidisciplinary
Masatoshi Kawahata, Haruka Yamamoto, Masahide Tominaga, Kentaro Yamaguchi
Summary: Disubstituted adamantanes with nitrophenol moieties were studied for their ability to recognize ketone and ester molecules through multiple intermolecular interactions, capturing the guest molecules through interactions with multiple functional groups.
Article
Chemistry, Multidisciplinary
Jieyu Zheng, Larissa K. S. von Krbek, Tanya K. Ronson, Jonathan R. Nitschke
Summary: Spin-crossover (SCO) metal-organic cages have the potential to be used as magnetic sensors and switches. Variations in the donor strength of heterocyclic aldehyde subcomponents in imine-based ligands can tune the ligand field for a Fe-II center, resulting in diverse SCO behaviors in the cages. The tetrahedral SCO cage built from 1-methyl-1H-imidazole-2-carbaldehyde can encapsulate various guests and stabilize different cage spin states depending on guest size. The SCO tetrahedron also exhibits different affinities for guests in different spin states, which is attributed to subtle structural differences caused by the change in the metal center spin state.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Inorganic & Nuclear
Shunsuke Ohtani, Kenichi Kato, Shixin Fa, Tomoki Ogoshi
Summary: Pillar[n]arenes, a new type of pillar-shaped host molecule, exhibit versatile and unique host-guest behaviors in host-guest chemistry. Solid-state host-guest complexation offers advantages such as cavity-size dependency, efficient complexation, and easy isolation and reuse. This review discusses recent developments in solid-state host-guest complexation using crystalline pillar[n]arenes, networks containing pillar[n]arenes, pillar[n]arene-assembled surfaces, and solid-state organic polymers.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Polymer Science
Daniele Zuccaccia, Roberta Pinalli, Rita De Zorzi, Monica Semeraro, Alberto Credi, Cristiano Zuccaccia, Alceo Macchioni, Silvano Geremia, Enrico Dalcanale
Summary: This study involves the design of materials with controlled properties based on the characteristics of supramolecular polymer family, investigating the aggregation model and intermolecular interactions at different concentrations. The analysis of experimental data shows slight differences in the aggregation model and decomposition mechanism at varying concentrations, providing important references for future material research.
Article
Polymer Science
Amy C. Madl, David Myung
Summary: Over 6.2 million people worldwide suffer from moderate to severe vision loss due to corneal disease. While transplantation with allogenic donor tissue is sight-restoring for many patients with corneal blindness, this treatment modality is limited by long waiting lists and high rejection rates. Host-guest interactions have emerged as an important crosslinking strategy for cytocompatible, minimally invasive, injectable tissue substitutes.
Article
Chemistry, Multidisciplinary
Hua Wei, Guangmeng Qu, Xiangyong Zhang, Baohui Ren, Shizhen Li, Jingjing Jiang, Yihan Yang, Jinlong Yang, Lingzhi Zhao, Hongfei Li, Chunyi Zhi, Zhuoxin Liu
Summary: In this study, a high-performance aqueous non-flow zinc-bromine battery (NF-ZBB) using a two-dimensional conjugated nickel polyphthalocyanine (NiPPc) as an adsorption-catalysis cathode host was developed. This innovative design addresses the critical issues of shuttle effect, low bromine utilization, and low discharge voltage in existing NF-ZBBs, significantly improving the electrochemical performance of the battery. Experimental measurements and theoretical simulations confirm that the atomically dispersed Ni-N-4 sites in NiPPc act as effective sites for bromine redox reactions and exhibit strong polarity for efficient adsorption of bromine and polybromides.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Article
Chemistry, Physical
Chengyang Yuan, Zhongyin Zhang, Jie Zhu, Jiafei Zhao, Lunxiang Zhang, Lei Yang, Yongchen Song, Dawei Tang
Summary: The underlying mechanism of limited lattice thermal conductivity in energy-related host-guest crystalline compounds has been studied. By using the time domain thermoreflectance technique and theoretical calculations, the ultralow thermal conductivity of xenon clathrate hydrate was investigated. It was found that localized guest modes hybridize with acoustic branches and severely limit the acoustic contribution. Additionally, guest fillers were found to cause significant phonon scattering in a wide range of frequencies.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Organic
Gang Wu, Sheng-Yi Zhuang, Yusran Yusran, Zhan-Ting Li, Dan-Wei Zhang
Summary: Paracyclophane has been understudied compared to other macrocyclic compounds, but through modification of pillar[5]arene, new pentagonal macrocycles (pseudo[n]-pillar[5]arenes) were obtained. These macrocycles showed the ability to form complexes with various guests in a 1:1 ratio. The binding constants decreased with the decrease of substituted phenylene segments. Notably, the conformation of P[n]P[5]s could adjust effectively when binding with succinonitrile in the solid state.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Agriculture, Multidisciplinary
Wenjie Li, Weiwei Xu, Siyun Zhang, Jia Li, Juan Zhou, Demei Tian, Jing Cheng, Haibing Li
Summary: Significant progress has been made in the research on drug encapsulation and release based on supramolecular macrocycles, laying a solid foundation for the development of novel nanopesticide preparations.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Organic
Patricia Maximo, Miriam Colaco, Sofia R. Pauleta, Paulo J. Costa, Uwe Pischel, A. Jorge Parola, Nuno Basilio
Summary: The synthetic receptor cucurbit[8]uril (CB8) can form high-affinity host-guest complexes with dicationic dithienylethene (DTE) photoswitches in water. The formation of these complexes is driven by a combination of hydrophobic effects, ion-dipole, hydrogen- and chalcogen-bonding interactions. The binding affinities are much higher for the closed isomers of DTE, providing ideal conditions for the development of robust photoswitchable host-guest complexes.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Engineering, Multidisciplinary
Beibei Wang, Hao Chen, Tan Liu, Shaowei Shi, Thomas P. Russell
Summary: Host-guest molecular recognition at the liquid-liquid interface endows the interface with unique properties, providing tremendous opportunities in the areas of encapsulation, delivery vehicles, and biphasic reaction systems. Increasing research efforts have been put into the preparation of supramolecular interfacial systems, showing promising applications in various fields.
Article
Chemistry, Multidisciplinary
Guotai Li, Fanny Trausel, Michelle P. van Der Helm, Benjamin Klemm, Tobias G. Breve, Susan A. P. van Rossum, Muhamad Hartono, Harm H. P. J. Gerlings, Matija Lovrak, Jan H. van Esch, Rienk Eelkema
Summary: The study explores the use of cucurbit[7]uril molecular container to modulate the activity of synthetic organocatalysts, successfully changing the activity of four different organocatalysts and one initiator, with the potential to regulate chemical reaction rates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Shanchao Tan, Hongyu Shi, Xin Du, Kunpeng Wang, Haijun Xu, Junhua Wan, Ke Deng, Qingdao Zeng, Yuhong Liu
Summary: Controlling friction by the electric field is a promising approach to improve the tribological performance. This study demonstrates the effective control of assembly structure and microscale superlubricity of a host-guest assembly using the electric field. The assembly behaviors of fullerene derivatives at different probe biases are characterized using STM and DFT techniques, and the controllability of the friction coefficient is confirmed by AFM. The insights gained from this research not only contribute to the understanding of the host-guest assembly mechanism controlled by the electric field, but also promote the application of fullerene in MEMS.
Review
Chemistry, Physical
Elodie V. d'Astous, Philippe Dauphin-Ducharme
Summary: The article discusses the signal transduction mechanisms of electrochemical host-guest sensing, explores the advantages and shortcomings of this method, and hopes to promote the development of commercial electrochemical devices based on host-guest chemistry.
CURRENT OPINION IN ELECTROCHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Yifeng Ni, Dong Zhang, Yang Wang, Xiaomin He, Jian He, Huimin Wu, Jingfeng Yuan, Dongyong Sha, Lingbin Che, Jun Tan, Jintao Yang
Summary: Development of a smart, host-guest interaction-mediated photo/temperature dual-controlled antibacterial surface shows triple successive antimicrobial functions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Zibin Zhang, Yu Yao, Lang He, Tao Hong, Shijun Li, Feihe Huang, Peter J. Stang
Summary: Coordination-driven self-assembly was utilized to construct two metallacycles using a dicarboxylate-functionalized dibenzo-18-crown-6 in combination with either a 0 degrees anthracene-based clip-type acceptor or a 60 degrees phenanthrene-based acceptor. The angularities of these components enabled the formation of a [2 + 2] rectangle and a [3 + 3] triangle, respectively. The synthesis, characterization, and host-guest chemistry of the two metallacycles were described and supported by 31P{1H}, 1H NMR spectra, and electrospray mass spectrometry. (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yu Yao, Jiyong Liu, Peiling Zhang, Kechang Sun, Leqiong Jin, Shijun Li, Feihe Huang, Zhigang Ni, Zibin Zhang
Summary: Self-assembly is a fundamental tool for constructing materials. Copillar[5]arenes, driven by CH center dot center dot center dot 7r interactions, are optimal models for building heteroditopic monomers. The self-assembly manner of copillar[5]arenes in the solid state depends on the competition between the pillar[5]arene cavity and the threading guest moiety or solvent molecules.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Ming Li, Yang Liu, Li Shao, Bin Hua, Mengbin Wang, Haozhong Liang, Niveen M. Khashab, Jonathan L. Sessler, Feihe Huang
Summary: Variable stoichiometry co-crystals are important in solid-state supramolecular chemistry as they allow for the study of structure-property relationships and the synthesis of new scaffolds. In this work, the concept of variable stoichiometry co-crystals is extended to pillararene chemistry, resulting in the construction of a diverse set of supramolecular structures. These co-crystals display different physicochemical properties and can be used for vapochromic-based detection.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Haozhong Liang, Yuting Yang, Li Shao, Weijie Zhu, Xiaofeng Liu, Bin Hua, Feihe Huang
Summary: It is found that using pillar[5]arene (BrP5) as the macrocyclic host to encapsulate nonlinear optical (NLO) materials (OM, DAST, and MNS) can change their solid-state packing and manipulate their centrosymmetric arrangements, achieving second harmonic generation (SHG) in the solid and crystalline states. This research opens a new way to construct solid-state organic NLO materials with potential applications in high-power lasers, optical switches, and imaging.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Polymer Science
Hui-Qing Peng, Wenping Zhu, Wu-Jie Guo, Qingyun Li, Shixiang Ma, Christophe Bucher, Bin Liu, Xiaofan Ji, Feihe Huang, Jonathan L. Sessler
Summary: Supramolecular polymers are self-assembled structures formed through noncovalent interactions, exhibiting reversibility, responsiveness, and stability. They have diverse applications in various fields. This review focuses on the determinants and driving forces of supramolecular polymer construction, highlighting the influence of different noncovalent interactions on their structure and function. Understanding these connections contributes to further advancements in this field.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xiaodan Xu, Rui Wang, Dongdong Li, Jiajia Xiang, Wei Zhang, Xueying Shi, Hongxia Xu, Shasha Yao, Jiwei Liu, Shiqun Shao, Zhuxian Zhou, Feihe Huang, Youqing Shen, Jianbin Tang
Summary: In this study, a pH-responsive polymer nanocarrier modified with aminoguanidine was developed for efficient delivery of bortezomib. The nanoparticles exhibited pH-responsive release in the acidic tumor microenvironment and induced immune activation and antigen uptake by dendritic cells. Consequently, they stimulated cytotoxic T lymphocyte infiltration and triggered robust antitumor immune responses, showing potent antitumor efficacy when combined with an immune checkpoint-blocking antibody.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Huaqiang Ju, Haoke Zhang, Li Xin Hou, Min Zuo, Miao Du, Feihe Huang, Qiang Zheng, Zi Liang Wu
Summary: We propose a facile strategy to achieve room-temperature phosphorescence in conventional hydrogels by polymerization-induced crystallization of dopant molecules, leading to clusterization-induced phosphorescence. Crown ethers dissolved in a concentrated acrylamide aqueous solution crystallize during polymerization to form large spherulites in the hydrogel, resulting in carbonyl clusters and phosphorescence emission. This strategy is universally applicable to hydrogels with different polymeric matrices and dopant molecules. The development of hydrogels with mechanical and phosphorescent properties holds great potential in the biomedical and engineering fields.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Huangtianzhi Zhu, Junkai Liu, Yitao Wu, Lei Wang, Haoke Zhang, Qi Li, Hu Wang, Hao Xing, Jonathan L. Sessler, Feihe Huang
Summary: In this study, a room-temperature phosphorescence (RTP) system responsive to alkyl halides was described. The system consisted of a meta-formylphenyl-bearing pillar[5]arene derivative that supported effective through-space charge transfer. Treatment with bromoethane enhanced the emission. An isomeric para-formylphenyl-bearing pillar[5]arene system proved ineffective in producing an RTP effect.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao, Yuan Ding, Weilin Wang
Summary: With the increasing demand for personalized medical care, supramolecular theranostic systems based on cyclodextrins (CDs) have become popular due to their reversible switchable structures, sensitive response to biological stimuli, and ability to integrate multiple capabilities in a programmable manner. This review focuses on the design of various functional modules and interactions in CD-based supramolecular systems for cancer diagnostics and therapeutics. By providing state-of-the-art examples, the review aims to enhance the understanding of the important role of cyclodextrin-based nanoplatforms in advancing supramolecular cancer theranostics.
Review
Polymer Science
Ruoqian Zhang, Rongrong Li, Feihe Huang, Mingming Zhang
Summary: This review summarizes the progress of metallacycle/metallacage-cored supramolecular networks, focusing on the structures connected by covalent or non-covalent interactions. The detailed descriptions of the structures, properties, functions, and applications of such networks are provided to showcase the exciting achievements in this emerging field. The review also highlights the remaining challenges and perspectives to attract more scientists to contribute to this promising area.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Zuping Xiong, Jianyu Zhang, Lei Wang, Yuan Xie, Yipu Wang, Zujin Zhao, Haoke Zhang, Jing Zhi Sun, Feihe Huang, Ben Zhong Tang
Summary: Nonconjugated clusteroluminogens (CLgens), such as proteins and polystyrene, have become increasingly important in photophysics due to their advantages over traditional conjugated dyes in biological applications. However, their weak visible emissions in the aggregate state have hindered their development. This study proposes a strategy to construct a higher-level intramolecular through-space interaction (TSI) in multi-aryl-substituted alkanes, resulting in efficient clusteroluminescence (CL) with high luminescence quantum yield and long emission wavelength.
Article
Multidisciplinary Sciences
Qiong Chen, Zhaoyong Li, Ye Lei, Yixin Chen, Hua Tang, Guangcheng Wu, Bin Sun, Yuxi Wei, Tianyu Jiao, Songna Zhang, Feihe Huang, Linjun Wang, Hao Li
Summary: Controlling the self-assembly on noncovalent components is possible by suppressing entropy loss with templates but this is challenging for covalent components. Here the authors employed directing groups to endow purely covalent molecular building blocks with different conformations which favor the formation of specific self-assembled products.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Xuedong Xiao, Ding Xiao, Guan Sheng, Tianyu Shan, Jiao Wang, Xiaohe Miao, Yikuan Liu, Guangfeng Li, Yihan Zhu, Jonathan L. Sessler, Feihe Huang
Summary: The integration of mechanically interlocked molecules (MIMs) into purely organic crystalline materials has been achieved using a dative boron-nitrogen bond-driven self-assembly strategy, resulting in the preparation of polyrotaxane crystals. The polyrotaxane structure of the crystalline material was confirmed by single-crystal X-ray diffraction analysis and cryogenic high-resolution low-dose transmission electron microscopy. The polyrotaxane crystals exhibit enhanced softness and greater elasticity compared to nonrotaxane polymer controls, attributed to the synergistic microscopic motion of the rotaxane subunits. This work highlights the importance of integrating MIMs into crystalline materials.
Review
Chemistry, Multidisciplinary
Dan Wu, Jiaqi Lei, Zhankui Zhang, Feihe Huang, Marija Buljan, Guocan Yu
Summary: The synthesis of vital biomacromolecules through the polymerization of small biomolecules to support and multiply life is an emerging field that showcases the diversity and efficiency of chemistry as well as the flexibility and ingenuity of physiological environment. Efforts have been made to design and develop in situ intra/extracellular polymerization reactions, which have found applications in various important research areas, including cell surface engineering, biocompatible polymerization, cell behavior regulation, living cell imaging, targeted bacteriostasis, and precise tumor therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Haozhong Liang, Yuting Yang, Li Shao, Weijie Zhu, Xiaofeng Liu, Bin Hua, Feihe Huang
Summary: In this study, pillar[5]arene was used as a host molecule to encapsulate NLO molecules (OM, DAST, and MNS) in order to change their solid-state packing and manipulate their centrosymmetric arrangements. Experimental results showed that different packing arrangements resulted in different levels of second harmonic generation (SHG). This research provides a new approach to construct solid-state organic NLO materials with potential applications in high-power lasers, optical switches, and imaging.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
