期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 12, 页码 14556-14564出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c21626
关键词
stimuli-responsive; polymeric brush; long-term antifouling; sequential release; antibacterial mechanism
资金
- National Natural Science Foundation of China [52073255, 51673175]
- Natural Science Foundation of Zhejiang Province [LZ20E030004, LY16E030012]
Development of a smart, host-guest interaction-mediated photo/temperature dual-controlled antibacterial surface shows triple successive antimicrobial functions.
Development of smart switchable surfaces to solve the inevitable bacteria attachment and colonization has attracted much attention; however, it proves very challenging to achieve on-demand regeneration for noncontaminated surfaces. We herein report a smart, host-guest interaction-mediated photo/temperature dual-controlled antibacterial surface, topologically combining stimuli-responsive polymers with nanobactericide. From the point of view of long-chain polymer design, the peculiar hydration layer generated by hydrophilic poly(2-hydroxyethyl methacrylate) (poly-HEMA) segments severs the route of initial bacterial attachment and subsequent proliferation, while the synergistic effect on chain conformation transformation poly(N-isopropylacrylamide) (polyNIPAM) and guest complex dissociation azobenzene/cyclodextrin (Azo/CD) complex greatly promotes the on-demand bacterial release in response to the switch of temperature and UV light. Therefore, the resulting surface exhibits triple successive antimicrobial functions simultaneously: (i) resists similar to 84.9% of initial bacterial attachment, (ii) kills similar to 93.2% of inevitable bacteria attack, and (iii) releases over 94.9% of killed bacteria even after three cycles. The detailed results not only present a potential and promising strategy to develop renewable antibacterial surfaces with successive antimicrobial functions but also contribute a new antimicrobial platform to biomedical or surgical applications.
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