Inhibition of p16INK4A to Rejuvenate Aging Human Cardiac Progenitor Cells via the Upregulation of Anti-oxidant and NFκB Signal Pathways

Molecular mechanism of doxorubicin-induced cardiomyopathy – An update

(2018) Kaviyarasi Renu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation

(2018) Xiangrui Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

(2017) Daniela D’Arcangelo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2

(2017) Larissa A. C. Carvalho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decline in cellular function of aged mouse c-kit+ cardiac progenitor cells

(2017) Alessandra Castaldi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2

(2017) Alakananda Basu et al.   PLoS One

Cytoglobin Promotes Cardiac Progenitor Cell Survival against Oxidative Stress via the Upregulation of the NFκB/iNOS Signal Pathway and Nitric Oxide Production

(2017) Shuning Zhang et al.   Scientific Reports

Heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis

(2016) C. Li et al.   HERZ

Preconditioning c-Kit-positive Human Cardiac Stem Cells with a Nitric Oxide Donor Enhances Cell Survival through Activation of Survival Signaling Pathways

(2016) Lei Teng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression

(2016) Panagiotis Mistriotis et al.   STEM CELLS

Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase

(2016) Eric Aeby et al.   Cell Reports

Microsolvation and hydration enthalpies of CaS2O3(H2O) n (n = 0–19) and S2O3 2−(H2O) n (n = 0–16): an ab initio study

(2015) Victor M. Rosas-García et al.   JOURNAL OF MOLECULAR MODELING

DJ-1 upregulates anti-oxidant enzymes and attenuates hypoxia/re-oxygenation-induced oxidative stress by activation of the nuclear factor erythroid 2-like 2 signaling pathway

(2015) YU-FENG YAN et al.   Molecular Medicine Reports

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

(2015) C Cerella et al.   Cell Death & Disease

Resident c-kit+ cells in the heart are not cardiac stem cells

(2015) Nishat Sultana et al.   Nature Communications

Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a

(2014) Mina Sasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression

(2014) Burcu Bayoglu et al.   Journal of Atherosclerosis and Thrombosis

c-kit+ cells minimally contribute cardiomyocytes to the heart

(2014) Jop H. van Berlo et al.   NATURE

Heme Oxygenase-1 Induction Improves Cardiac Function following Myocardial Ischemia by Reducing Oxidative Stress

(2014) Yossi Issan et al.   PLoS One

Rejuvenation of Human Cardiac Progenitor Cells With Pim-1 Kinase

(2013) Sadia Mohsin et al.   CIRCULATION RESEARCH

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

(2013) R. L. Thomas et al.   GENES & DEVELOPMENT

Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration

(2013) S. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

(2013) J. Cadet et al.   Cold Spring Harbor Perspectives in Biology

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Telomeres and Mitochondria in the Aging Heart

(2012) Javid Moslehi et al.   CIRCULATION RESEARCH

The Heme Oxygenase 1 Inducer (CoPP) Protects Human Cardiac Stem Cells against Apoptosis through Activation of the Extracellular Signal-regulated Kinase (ERK)/NRF2 Signaling Pathway and Cytokine Release

(2012) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial

(2012) Raj R Makkar et al.   LANCET

Nanog Reverses the Effects of Organismal Aging on Mesenchymal Stem Cell Proliferation and Myogenic Differentiation Potential

(2012) Juhee Han et al.   STEM CELLS

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Effects of Age and Heart Failure on Human Cardiac Stem Cell Function

(2011) Daniela Cesselli et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel cross-talk within the IKK family controls innate immunity

(2011) Kristopher Clark et al.   BIOCHEMICAL JOURNAL

All-trans retinoic acid induces cellular senescence via upregulation of p16, p21, and p27

(2011) Sun-Hye Park et al.   CANCER LETTERS

Peroxiredoxin 1 and its role in cell signaling

(2011) Carola A. Neumann et al.   CELL CYCLE

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

Sulfiredoxin Protein Is Critical for Redox Balance and Survival of Cells Exposed to Low Steady-state Levels of H2O2

(2011) Jin Young Baek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockdown of Cyclin-dependent Kinase Inhibitors Induces Cardiomyocyte Re-entry in the Cell Cycle

(2011) Valeria Di Stefano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial

(2011) Roberto Bolli et al.   LANCET

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

The effects of nitric oxide-oxidase and putative glutathione-peroxidase activities of ceruloplasmin on the viability of cardiomyocytes exposed to hydrogen peroxide

(2010) Mylène Paradis et al.   FREE RADICAL BIOLOGY AND MEDICINE

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart

(2010) Maria Mirotsou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation

(2010) Yoshihiro Tsuchiya et al.   MOLECULAR CELL

Calcineurin Activates Cytoglobin Transcription in Hypoxic Myocytes

(2009) Sarvjeet Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomere length measurement by a novel monochrome multiplex quantitative PCR method

(2009) R. M. Cawthon   NUCLEIC ACIDS RESEARCH

Regulation of Cardiomyocyte Proliferation and Myocardial Growth During Development by FOXO Transcription Factors

(2008) Heather J. Evans-Anderson et al.   CIRCULATION RESEARCH

IκB kinase β (IKKβ/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-κB

(2008) Johannes A. Schmid et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Risk factors for myocardial infarction in women and men: insights from the INTERHEART study

(2008) Sonia S. Anand et al.   EUROPEAN HEART JOURNAL

Stem-cell therapy for cardiac disease

(2008) Vincent F. M. Segers et al.   NATURE