Article
Engineering, Biomedical
Dong Liang, Xiaoyi Zhang, Yi Wang, Taotao Huo, Min Qian, Yibo Xie, Wenshuai Li, Yunqiu Yu, Wei Shi, Qianqian Liu, Junle Zhu, Chun Luo, Zhijuan Cao, Rongqin Huang
Summary: In this study, a fluorescent signal amplified miRNA biosensor was constructed using dispersed magnetic covalent organic framework nanospheres (MCOF) as cores and high-crystalline COF as shells. The biosensor showed sensitive detection of miRNA-182 in different matrixes and could quantify miRNA-182 in serum of glioma patients, suggesting its potential application in sensitive detection and accurate diagnosis/prognosis of glioma.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Analytical
Lei Liu, Yue Yao, Kejian Ma, Changjian Shangguan, Songlong Jiao, Songyang Zhu, Xiaoxuan Xu
Summary: This study presents a strategy to enhance charge separation efficiency by fabricating hierarchical Ti3C2@ReS2, leading to ultrasensitive PEC detection of cancer-related miRNA-141 with a greatly improved detection limit and excellent detection range.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Environmental
Mengqi Pan, Weiwei Cao, Ruo Yuan, Haijun Wang
Summary: In this study, lamellar nanostructures (LNs) of [-TPE-(COOH)4-Al-]nLNs were synthesized through the coordination between Al3+ and carboxyl groups of TPE-(COOH)4. The obtained [-TPE-(COOH)4-Al-]nLNs showed excellent aggregation-induced electrochemiluminescence (AIECL) and higher electrochemiluminescence (ECL) efficiency compared to TPE-(COOH)4. They also demonstrated better cost and biocompatibility compared to coordination aggregation structures with heavy metal or rare metal ions. Furthermore, the [-TPE-(COOH)4-Al-]nLNs were used as a luminescent material to fabricate an ultrasensitive ECL biosensor for miRNA-141 detection using the cascaded strand displacement amplification (CSDA) strategy. The biosensor exhibited excellent detection performance with a wide linear range and low detection limit. This study provides a convenient and effective AIECL strategy for TPE derivatives and expands the application of ECL technology in ultra-sensitive biochemical detection.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Ali Khodadoust, Navid Nasirizadeh, Seyed Morteza Seyfati, Ramezan Ali Taheri, Mostafa Ghanei, Hasan Bagheri
Summary: In this study, a novel nano-biosensor has been developed using dual signal-labeled hairpin-structured DNA-based probes. The biosensor can sensitively and simultaneously detect miRNA-141 and miRNA-21, and it is resistant to interference from environmental factors.
Article
Chemistry, Analytical
Xianghui Li, Yilei Lu, Yiming Chen, Zhipeng Pan, Ni Lin, Zhenyu Lin, Huixing Chen
Summary: A signal-on low background electrochemiluminescence (ECL) biosensor for microRNA-141 (miRNA-141) detection was developed based on the electrostatic attraction difference between negatively charged report probes and positively charged electrode. The biosensor utilized a modified indium tin oxide (ITO) electrode with a positively charged surface to achieve low background signal by electrostatic repulsion with dichlorotris (1,10-phenanthroline) ruthenium (II) hydrate (Ru(phen)(3)(2+)). The target triggered a cascade reaction to generate negatively charged long dsDNAs, which efficiently loaded Ru(phen)(3)(2+) (Ru-dsDNA) and resulted in a strong ECL signal.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Yang Yang, Jia-Ling Zhang, Wen-Bin Liang, Jin-Ling Zhang, Xiao-Li Xu, Yong-Jiang Zhang, Ruo Yuan, Dong-Rong Xiao
Summary: A conductive bimetallic MOF nanorod (NiCo-HHTP) with excellent electrical conductivity and ECL performance was synthesized using a doping strategy, which could be utilized for constructing ultrasensitive ECL biosensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Yanjie Zheng, Li Chen, Xinyang Yin, Fei Lin, Yichun Xu, Xinhua Lin, Shaohuang Weng
Summary: A dual-mode electrochemical biosensor has been developed for the sensitive detection of femtomolar miRNA-155 using electrochemiluminescence (ECL) and adsorptive stripping voltammetry (AdsSV). The sensor demonstrates high selectivity, reproducibility and long-term stability, providing a practical platform for rapid, simple, selective and reliable detection of miRNAs.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Jie Zhang, Huiqian Zhou, Tingting Hao, Yiyao Yang, Qingqing Zhang, Jinyun Li, Meng Ye, Yangbo Wu, Wanlei Gao, Zhiyong Guo
Summary: A Faraday cage-type electrochemiluminescence biosensor was developed for the detection of MCF-7 breast cancer cells. Fe3O4-APTs and GO@PTCA-APTs were synthesized as capture and signal units, respectively. The sensor achieved a significant increase in sensitivity by assembling numerous electrochemiluminescence signal probes and adopting a double aptamer recognition strategy.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Xiaoshuang Chen, Dongyu Zhang, Han Lin, Wenting Wei, Tingting Hao, Yufang Hu, Sui Wang, Zhiyong Guo
Summary: A MXene-catalyzed immunosensor was developed for detecting Cry1Ab protein in GM crops, showing high sensitivity and detection capability. The sensor structure, combined with MXene catalysis, enhances the ECL reaction for improved detection sensitivity. The system demonstrated satisfactory performance in terms of selectivity, stability, repeatability, precision, and accuracy, with successful detection of actual samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Robert J. Forster, David C. Henshall, Hany El Naggar, Yann Pellegrin, Norman Delanty
Summary: This study reports the detection of a key biomarker in epilepsy, miR-134, using an environmentally sensitive electrochemiluminescent luminophore, [Ru(DPPZ)(2)PIC](2+). The ability of the sensor to quantify miR-134 in unprocessed plasma samples from healthy volunteers and people with epilepsy is demonstrated.
BIOELECTROCHEMISTRY
(2022)
Article
Biophysics
Qian Han, Cun Wang, Pingkun Liu, Gui Zhang, Li Song, Yingzi Fu
Summary: The research improved ECL intensity and stability by synthesizing europium and TCPP coordination polymer for detecting the tumor biomarker MUC1. A ternary ECL biosensor was constructed with Exo III-assisted amplification strategy, showing high sensitivity and wide linear range.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Materials Science, Multidisciplinary
Daniel Canseco-Caballero, Antonio Ledezma-Perez, Carmen Alvarado-Canche, Marco Antonio Castillo-Campohermoso, Carlos Gallardo-Vega, Enrique Diaz Barriga-Castro, Agustin L. Herrera-May, Esmeralda Saucedo-Salazar, Arxel de Leon
Summary: This article introduces a method for detecting the harmful effects of herbicides on human health. By combining zinc oxide nanorods functionalized with silver nanoparticles and ruthenium-based electrochemiluminescence sensors, a reliable sensor is constructed for the detection and quantification of herbicides in food samples.
Article
Chemistry, Analytical
Kailun Ji, Yifei Wang, Lebao Mao, Yuzhe Wang, Xiuhua Zhang
Summary: A novel ECL biosensor based on sulfur quantum dots and DNA Walker with dual-amplification strategy has been developed for sensitive detection of miRNA-141, achieving a low detection limit and a wide detection range.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Environmental
Jinge Zhao, Cuiping Fu, Chuan Huang, Sibao Zhang, Fangfang Wang, Yan Zhang, Lina Zhang, Shenguang Ge, Jinghua Yu
Summary: The article introduces a photoelectrochemical (PEC) biosensor constructed based on a cascade enzyme-assisted cycling process and Co3O4-Au polyhedron for miRNA-141 detection. By specific interactions and competitive consumption effects, the photocurrent signal can be reduced to achieve accurate detection in biosensing applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Ni Liao, Mei-Chen Pan, Jin-Feng Chen, Xia Zhong, Ruo Yuan, Ying Zhuo
Summary: In this work, a dual engine-triggered DNA walker was designed based on a precise orientation protocol, and Pe-TiO2 nanospheres were used as ECL emitters. The combination of the DNA walker and the ternary ECL system resulted in an efficient ECL bioassay platform for microRNA detection.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Qi Wang, Tao Wang, Han Lin, Weiqiang Meng, Chunfeng Zhang, Pingru Cai, Tingting Hao, Yangbo Wu, Zhiyong Guo
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Analytical
Qingqing Zhang, Dandan Hu, Tianyu Zhan, Yufang Hu, Zhiyong Guo, Sui Wang
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Analytical
Chunfeng Zhang, Tingting Hao, Han Lin, Qi Wang, Yangbo Wu, Kai Kang, Xueping Ji, Zhiyong Guo
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Analytical
Dandan Hu, Tianyu Zhan, Zhiyong Guo, Sui Wang, Yufang Hu
Summary: A novel dual-modality readout biosensing method was developed for the analysis of Cu(II), coenzyme (CoA), and histone acetyltransferase (HAT) activity. The method effectively detects and quantifies these compounds using Ru-MOF as a probe, demonstrating bidirectional detection of Cu(II) and quantification of CoA and HAT p300 activity.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Wenting Wei, Han Lin, Tingting Hao, Sui Wang, Yufang Hu, Zhiyong Guo, Xingyu Luo
Summary: The study developed a sensitive biosensor with triple signal outputs for the detection of pathogenic bacteria, achieving high detection sensitivity and accuracy. It shows great potential in applications related to food safety, water quality, and biological contamination.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Daquan Li, Mei Huang, Ziyu Shi, Liang Huang, Jiening Jin, Chenxing Jiang, Wenbo Yu, Zhiyong Guo, Jing Wang
Summary: Antibiotics abuse poses a threat to human health and ecological environment. A competitive lateral flow immunoassay (CLFIA) platform with flexible readout was developed for the rapid detection of enrofloxacin. The platform utilizes three-dimensionally assembled gold nanoparticles as signal reporters, enabling qualitative screening and quantitative detection of enrofloxacin at low concentrations using the naked eye, optical scanner, or smartphone.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Haoran Ge, Xiaofu Wang, Junfeng Xu, Han Lin, Huiqian Zhou, Tingting Hao, Yangbo Wu, Zhiyong Guo
Summary: The dual-mode electrochemical biosensor designed using CRISPR/Cas12a system enables sensitive detection of genetically modified soybean without the need for PCR amplification, showing high accuracy and reliability. The detection method is simple to operate, with good stability and selectivity, suitable for rapid testing at room temperature.
ANALYTICAL CHEMISTRY
(2021)
Article
Electrochemistry
Qi Wang, Tingting Hao, Kaiyue Hu, Lingxia Qin, Xinxin Ren, Zhiyong Guo, Sui Wang, Yufang Hu
Summary: A novel circuit system with autonomous compensation solution ohmic drop is developed to improve the signal generation of traditional electrochemical biosensors. It is successfully applied for the analysis of terminal deoxynucleotide transferase (TdT) and its small molecule inhibitors, as well as mimicking TdT-related signal communication in various logic gates.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Xiaoshuang Chen, Dongyu Zhang, Han Lin, Wenting Wei, Tingting Hao, Yufang Hu, Sui Wang, Zhiyong Guo
Summary: A MXene-catalyzed immunosensor was developed for detecting Cry1Ab protein in GM crops, showing high sensitivity and detection capability. The sensor structure, combined with MXene catalysis, enhances the ECL reaction for improved detection sensitivity. The system demonstrated satisfactory performance in terms of selectivity, stability, repeatability, precision, and accuracy, with successful detection of actual samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Han Lin, Hideyuki Mitomo, Yusuke Yonamine, Zhiyong Guo, Kuniharu Ijiro
Summary: In this study, a stimulus-responsive system based on chiral molecule-achiral plasmonic nanoparticles was proposed, allowing for precise control of plasmon and its induced chiroptical activities. This design provides an open platform for flexible and rational tailoring of plasmonic cores, chiral molecules, and variable dielectrics, which is important for applications in chemical sensing, chiral nanocatalysis, and optical devices.
CHEMISTRY OF MATERIALS
(2022)
Article
Electrochemistry
Qingqing Zhang, Lingxia Qin, Kaiyue Hu, Xinxin Ren, Zhiyong Guo, Sui Wang, Yufang Hu
Summary: A versatile electrochemical platform based on Cu(II) coordination by pyrophosphatase (PPase)-guided triggered-release system is constructed. The platform is sensitive, selective, stable, and convenient for the quantitative detection of PPase, providing an important reference for PPi/PPase-based biological processes and clinical determinations.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Huiqian Zhou, Han Lin, Qi Wang, Tingting Hao, Yufang Hu, Sui Wang, Zhiyong Guo
Summary: We developed an axis-mode donor-DNA-acceptor electrochemical system to distinguish electron transfer modes in DNA. By embedding the redox probe Ag+ in the DNA strand and controlling the number of Ag+, the distance between Ag+ and the electrode, and the chemical environment, the rotation and bending of the DNA strand were restricted, allowing precise control of the electron transfer mechanism. The results showed that electron transfer in DNA occurs through tunneling rather than hopping.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Huiqian Zhou, Wenbo Guo, Shian Wang, Tingting Hao, Zhaoliang Wang, Yufang Hu, Sui Wang, Jianjun Xie, Xiaohua Jiang, Zhiyong Guo
Summary: An electrochemical aptasensor has been developed for ultrasensitive detection of Staphylococcus aureus (SA) based on stepwise signal amplification. The sensor exhibits good detection performance and wide applicability to other pathogens.
Article
Chemistry, Analytical
Jie Zhang, Huiqian Zhou, Tingting Hao, Yiyao Yang, Qingqing Zhang, Jinyun Li, Meng Ye, Yangbo Wu, Wanlei Gao, Zhiyong Guo
Summary: A Faraday cage-type electrochemiluminescence biosensor was developed for the detection of MCF-7 breast cancer cells. Fe3O4-APTs and GO@PTCA-APTs were synthesized as capture and signal units, respectively. The sensor achieved a significant increase in sensitivity by assembling numerous electrochemiluminescence signal probes and adopting a double aptamer recognition strategy.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Kai Kang, Beibei Wang, Xueping Ji, Yuheng Liu, Wenrui Zhao, Yaqing Du, Zhiyong Guo, Jujie Ren
Summary: This study reported a new type of artificial nanozyme based on Hemin-doped-HKUST-1 for the detection of dopamine. The nanozyme showed excellent electrocatalytic activity and potential value in clinical work, demonstrating a high sensitivity and wide linear range for dopamine detection in serum samples.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
