Review
Immunology
Pablo Mata-Martinez, Marta Bergon-Gutierrez, Carlos del Fresno
Summary: Dectin-1, a C-type lectin receptor, plays a crucial role in antifungal responses and immune memory. It recognizes various ligands and triggers different immune reactions. However, the underlying mechanisms of its involvement in trained immunity are not fully understood.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Pedro Henrique de Oliveira Cardoso, Ana Paula de Araujo Boleti, Patricia Souza E. Silva, Lincoln Takashi Hota Mukoyama, Alexya Sandim Guindo, Luiz Filipe Ramalho Nunes de Moraes, Caio Fernando Ramalho de Oliveira, Maria Ligia Rodrigues Macedo, Cristiano Marcelo Espinola Carvalho, Alinne Pereira de Castro, Ludovico Migliolo
Summary: The importance of neuroinflammation is increasingly recognized in neurological disorders, including both inflammatory diseases like multiple sclerosis and non-inflammatory conditions such as stroke, epilepsy, and cancer. A peptide called Ca-MAP1, inspired by a toxin from C. albicans, has shown promising anti-neuroinflammatory, antibacterial, and cytotoxic activity. In vitro and in silico studies demonstrated its effectiveness at lower concentrations, with low toxicity to normal cells. Ca-MAP1 also exhibited activity against various bacteria and demonstrated anti-neuroinflammatory effects. This peptide holds potential for controlling infections and serving as an alternative therapy for cancer.
Review
Immunology
Jemima Ho, Giorgio Camilli, James S. Griffiths, Jonathan P. Richardson, Nessim Kichik, Julian R. Naglik
Summary: Advancements in mycology have highlighted the significant impact of fungal microbes on human health. Candida albicans, a common fungus, not only causes infections but is also associated with various inflammatory disorders, suggesting new avenues for research.
Article
Food Science & Technology
Selene Mogavero, Sarah Hoefs, Alexa N. Lauer, Rita Mueller, Sascha Brunke, Stefanie Allert, Franziska Gerwien, Sabrina Groth, Edward Dolk, Duncan Wilson, Thomas Gutsmann, Bernhard Hube
Summary: Candidalysin, a peptide toxin produced by Candida albicans, is identified as the hemolytic factor of the organism. Its hemolytic activity is regulated by the P7 peptide. The purinergic receptor antagonist PPADS can neutralize the hemolytic effect of candidalysin and also affects its membrane intercalation ability. Antibodies targeting candidalysin show potential for neutralization and future anti-Candida therapy.
Review
Immunology
Yufei He, Jia Liu, Yutong Chen, Lan Yan, Jianhua Wu
Summary: Candida albicans activates neutrophils to release NETs as a defense mechanism, while also developing specific strategies to respond to the attack by NETs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Pedro H. F. Sucupira, Tauany R. Moura, Isabella L. S. Gurgel, Tassia T. P. Pereira, Ana C. B. Padovan, Mauro M. Teixeira, Diana Bahia, Frederico M. Soriani
Summary: Candida albicans is a commensal fungus that can cause nosocomial infections in immunocompromised individuals. In this study, the virulence variability of different clinical isolates of C. albicans was investigated. The results showed that different isolates exhibited different abilities to evade macrophage phagocytosis and resist oxidative stress, which correlated with their mortality rates in an animal model of candidiasis. This study highlights the importance of in vitro and in vivo functional characterizations for determining the virulence of different clinical isolates.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biology
Li Bao, Ying Zhang, Guoying Zhang, Dechun Jiang, Dan Yan
Summary: Beta-glucan from Candida albicans promotes insulin resistance and metabolic disorders in high-fat diet induced mice, and Candida albicans is enriched in type 2 diabetes (T2D) patients, suggesting a role of gut mycobiota in the development of T2D. Gut commensal fungi play an important role in the regulation of T2D and related metabolic disorders, as demonstrated by the protective effect of eliminating fungi on insulin resistance and metabolic disorders in mice. The beta-glucan from Candida albicans accelerates insulin resistance and related disorders through the dectin-1 dependent pathway.
COMMUNICATIONS BIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Kyla S. Ost, June L. Round
Summary: The importance of commensal fungi in health and disease is increasingly recognized, especially their involvement in intestinal diseases. This review explores the potential therapeutic opportunities of targeting fungi and their interactions. While fungi account for a smaller proportion of the microbiota, they have a significant biomass and their metabolic pathways are complex. The review discusses the specific roles of commensal fungi in intestinal diseases, interactions with intestinal bacteria, and the immune system, as well as the potential beneficial effects.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Kyla S. Ost, Teresa R. O'Meara, W. Zac Stephens, Tyson Chiaro, Haoyang Zhou, Jourdan Penman, Rickesha Bell, Jason R. Catanzaro, Deguang Song, Shakti Singh, Daniel H. Call, Elizabeth Hwang-Wong, Kimberly E. Hanson, John F. Valentine, Kenneth A. Christensen, Ryan M. O'Connell, Brendan Cormack, Ashraf S. Ibrahim, Noah W. Palm, Suzanne M. Noble, June L. Round
Summary: The study reveals the crucial role of adaptive immune response in suppressing harmful fungal effectors, benefiting both Candida albicans and its host. IgA plays a key role in targeting specific adhesins to suppress the pathogenic hyphal morphotype of Candida, promoting intestinal homeostasis.
Article
Immunology
Pu Song, Ge Peng, Hainan Yue, Takasuke Ogawa, Shigaku Ikeda, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: This study investigated the effect of Candidalysin on mast cell (MC) activation and the underlying molecular mechanism. The results showed that Candidalysin enhanced MC degranulation, migration, and production of cytokines, eicosanoids, and reactive oxygen species. Additionally, Candidalysin increased the expression of Dectin-1, and inhibiting Dectin-1 reduced MC activation.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Selene Mogavero, Frank M. Sauer, Sascha Brunke, Stefanie Allert, Daniela Schulz, Stephanie Wisgott, Nadja Jablonowski, Osama Elshafee, Thomas Krueger, Olaf Kniemeyer, Axel A. Brakhage, Julian R. Naglik, Edward Dolk, Bernhard Hube
Summary: Candidalysin is a peptide toxin secreted by C. albicans causing epithelial damage. Specific fungal attributes are required for candidalysin delivery to host cell membranes. The toxin accumulates in invasion pockets created by invasive hyphae, as visualised using camelid nanobodies.
CELLULAR MICROBIOLOGY
(2021)
Article
Immunology
Liting Hu, Guitao Bai, Qiang Xu, Guiqiu Zhao, Nan Jiang, Hua Yao, Xueqing Liu, Zhaodong Du
Summary: Candidalysin, a fungal peptide toxin secreted by Candida albicans, causes epithelial cell damage and activates inflammatory responses. The role of candidalysin in Candida albicans corneal keratitis and its regulation of the inflammatory response through the TREM-1/DAP12 pathway were investigated in this study. Results showed that candidalysin initiates an inflammatory response and regulates cytokine expression through TREM-1/DAP12 pathway and ERK phosphorylation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Itai Doron, Irina Leonardi, Xin Li, William D. Fiers, Alexa Semon, Meghan Bialt-DeCelie, Melanie Migaud, Iris H. Gao, Woan-Yu Lin, Takato Kusakabe, Anne Puel, Iliyan D. Iliev
Summary: This study reveals the important role of gut commensal fungi in shaping the human antibody repertoire through CARD9-dependent induction of host-protective antifungal IgG.
Candida albicans is the major inducer of antifungal immunoglobulin G (IgG) and provides protection against disseminated candidiasis.
Article
Multidisciplinary Sciences
Camila O. S. Souza, Natalia Ketelut-Carneiro, Cristiane M. Milanezi, Lucia H. Faccioli, Luiz G. Gardinassi, Joao S. Silva
Summary: The NLR molecule NLRC4 has been found to promote susceptibility to experimental PCM by regulating cytokine production and protective effector mechanisms. It suppresses prostaglandin E-2 production early in infection, reducing IL-1 beta release and impacting IL-18 release later in the disease, ultimately affecting immune responses and mortality.
Review
Microbiology
Jordan Leroy, Karine Lecointe, Pauline Coulon, Boualem Sendid, Raymond Robert, Daniel Poulain
Summary: This review summarizes the importance of monoclonal antibody 5B2 in understanding the molecular mechanisms, diagnosis, and clinical applications of Candida infections. The study of this antibody has revealed the pathogenic behavior of Candida and provided a highly sensitive method for diagnosing infectious diseases.
Review
Dermatology
M. Karimova, D. Moyes, M. Ide, J. F. Setterfield
Summary: The incidence of autoimmune diseases has been increasing significantly for several decades. Genetic factors may not be the only trigger for disease development, with dysbiosis of the microbiome also playing a role. While the role of the microbiome in common skin disorders like psoriasis is well understood, more research is needed on rare diseases like lichen planus.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Microbiology
Mate Vadovics, Jemima Ho, Nora Igaz, Robert Alfoldi, David Rakk, Eva Veres, Balazs Szucs, Marton Horvath, Renata Toth, Attila Szucs, Andrea Csibi, Peter Horvath, Laszlo Tiszlavicz, Csaba Vagvolgyi, Joshua D. Nosanchuk, Andras Szekeres, Monika Kiricsi, Rhonda Henley-Smith, David L. Moyes, Selvam Thavaraj, Rhys Brown, Laszlo G. Puskas, Julian R. Naglik, Attila Gacser
Summary: Oral Candida albicans infection is associated with the development and progression of oral squamous cell carcinoma (OSCC). Candida albicans promotes the progression of OSCC by stimulating the production of matrix metalloproteinases, oncometabolites, protumor signaling pathways, and overexpression of prognostic marker genes associated with metastatic events. Candida albicans also upregulates oncogenes in nonmalignant cells.
Article
Microbiology
Jonathan P. Richardson, Rhys Brown, Nessim Kichik, Sejeong Lee, Emily Priest, Selene Mogavero, Corinne Maufrais, Don N. Wickramasinghe, Antzela Tsavou, Natalia K. Kotowicz, Olivia W. Hepworth, Ana Gallego-Cortes, Nicole O. Ponde, Jemima Ho, David L. Moyes, Duncan Wilson, Christophe D'Enfert, Bernhard Hube, Julian R. Naglik
Summary: The study identifies the first family of peptide toxins, called candidalysins, in human-pathogenic fungi. These toxins are secreted by Candida albicans, Candida dubliniensis, and Candida tropicalis, and are responsible for causing cell damage, calcium influx, and activation of signaling pathways and cytokine secretion. Candidalysins from C. dubliniensis and C. tropicalis exhibit higher damaging and activation potential than C. albicans candidalysin, with faster membrane binding and disruption.
Article
Multidisciplinary Sciences
Xin Li, Irina Leonardi, Gregory G. Putzel, Alexa Semon, William D. Fiers, Takato Kusakabe, Woan-Yu Lin, Iris H. Gao, Itai Doron, Alejandra Gutierrez-Guerrero, Meghan B. DeCelie, Guilhermina M. Carriche, Marissa Mesko, Chen Yang, Julian R. Naglik, Bernhard Hube, Ellen J. Scherl, Iliyan D. Iliev
Summary: The study reveals the rich genetic diversity of pathogenic Candida albicans strains in the colonic mucosa of patients with inflammatory bowel disease, with some strains having high immune-cell-damaging capacity (HD strains). These strains exacerbate intestinal inflammation in vivo through specific mechanisms, highlighting new insights into host-fungal interactions and potential diagnostic and therapeutic targets for inflammatory diseases.
Editorial Material
Microbiology
Jonathan P. Richardson
Article
Biochemistry & Molecular Biology
Nicole O. Ponde, Lea Lortal, Antzela Tsavou, Olivia W. Hepworth, Don N. Wickramasinghe, Jemima Ho, Jonathan P. Richardson, David L. Moyes, Sarah L. Gaffen, Julian R. Naglik
Summary: The EGFR-MAPK signaling pathway plays a key role in the response of oral epithelial cells to C. albicans infection, requiring factors such as candidalysin, EGFR phosphorylation, MMPs, and cellular calcium flux. Among the identified signaling effectors, Gab1, Grb2, and Shp2 are the main drivers of ERK1/2 activation and the production of downstream innate immune cytokines.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Abdulaziz Bakhsh, Noor Al-Abdulla, Francesco Mannocci, Marwa Allihaibi, David Moyes, Gordon Proctor, Sadia Ambreen Niazi
Summary: This study aimed to evaluate the effect of apical periodontitis and its treatment on salivary inflammatory markers and investigate their correlation with serum markers. Saliva samples were collected from 115 participants and analysed using a multiplex immunoassay. Salivary cytokines, MMPs, and vascular adhesion molecules were higher at review appointments, while hs-CRP levels were significantly higher in the treatment group. Correlation between salivary and serum biomarkers suggests saliva sampling as a feasible non-invasive option for measuring inflammatory markers.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Noor Al-Abdulla, Abdulaziz Bakhsh, Francesco Mannocci, Gordon Proctor, David Moyes, Sadia Ambreen Niazi
Summary: The aim of this study was to investigate serum biomarkers of inflammation 2 years following non-surgical root canal re-treatment (Re-RCT) and peri-apical surgery (PS), and their correlation with signs and symptoms, treatment outcome, metabolic syndrome factors, infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) and COVID-19 vaccination. The results showed that hs-CRP, ADMA, and MMP-2 can be considered as prognostic biomarkers for successful Re-RCT and PS, as their levels reduced at the 2-year recall in cases with evidence of clinical and radiographic success. The successful treatment of chronic apical periodontitis is associated with improvements in metabolic syndrome indicators, better glycemic control, and reduction of certain systemic inflammatory markers related to cardiovascular disease risks at the 2-year mark.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Yuchen Zhang, Emily Ming-Chieh Lu, David Moyes, Sadia Ambreen Niazi
Summary: This systematic review evaluates the impact of peri-implantitis on metabolic syndrome and provides management suggestions for patients with metabolic disorders. The findings suggest an association between peri-implantitis and altered metabolic factors, including lipid profile and HbA1c level. However, more high-quality studies are needed to confirm these results.
APPLIED SCIENCES-BASEL
(2023)
Review
Infectious Diseases
Blair Merrick, Chrysi Sergaki, Lindsey Edwards, David L. Moyes, Michael Kertanegara, Desiree Prossomariti, Debbie L. Shawcross, Simon D. Goldenberg
Summary: Antimicrobial resistance (AMR) presents a significant burden to the global healthcare system, particularly in Gram-negative organisms such as extended-spectrum beta-lactamase and carbapenemase-producing Enterobacterales (ESBL and CPE). These pathogens have limited treatment options, leading to poor clinical outcomes. Manipulating the gut microbiota through various methods, including diet, probiotics, bacteriophages, and fecal microbiota transplantation (FMT), can effectively restore colonization resistance and limit the spread of AMR organisms.
INFECTIOUS DISEASE REPORTS
(2023)
Article
Chemistry, Medicinal
Jihui Zhang, Jie Chen, Jonathan P. Richardson, Nicola-Jane Francis-Newton, Pei F. Lai, Kerry Jenkins, Meriel R. Major, Rebekah E. Key, Mark E. Stewart, Stuart Firth-Clark, Steven M. Lloyd, Gary K. Newton, Trevor R. Perrior, David R. Garrod, Clive Robinson
Summary: This study demonstrated that target-selective inhibitors of group 1 house dust mite (HDM) allergens can effectively suppress acute airway responses and attenuate Th2 pathway activation, providing a novel approach to treating multiple allergic diseases where HDMs play a prominent role.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
Article
Microbiology
Jonathan P. Richardson, Rhys Brown, Nessim Kichik, Sejeong Lee, Emily Priest, Selene Mogavero, Corinne Maufrais, Don N. Wickramasinghe, Antzela Tsavou, Natalia K. Kotowicz, Olivia W. Hepworth, Ana Gallego-Cortes, Nicole O. Ponde, Jemima Ho, David L. Moyes, Duncan Wilson, Christophe D'Enfert, Bernhard Hube, Julian R. Naglik
Summary: The study identified Candidalysin as the first family of peptide cytolysins in human-pathogenic fungi, with orthologs found in C. dubliniensis and C. tropicalis. These candidalysins have different amino acid sequences, exhibit a-helical structures, and show higher damaging and activation potential compared to C. albicans candidalysin. This discovery suggests a new avenue for understanding and potentially targeting fungal infections caused by various Candida species.
Article
Microbiology
Mate Vadovics, Jemima Ho, Nora Igaz, Robert Alfoldi, David Rakk, Eva Veres, Balazs Szucs, Marton Horvath, Renata Toth, Attila Szucs, Andrea Csibi, Peter Horvath, Laszlo Tiszlavicz, Csaba Vagvolgyi, Joshua D. Nosanchuk, Andras Szekeres, Monika Kiricsi, Rhonda Henley-Smith, David L. Moyes, Selvam Thavaraj, Rhys Brown, Laszlo G. Puskas, Julian R. Naglik, Attila Gacser
Summary: This study demonstrates that Candida albicans infection may enhance the development and progression of oral squamous cell carcinoma by stimulating the production of matrix metalloproteinases, oncometabolites, and protumor signaling pathways. The research also indicates that Candida colonization in the oral cavity can induce the overexpression of metastatic genes and significant changes in markers of epithelial-mesenchymal transition.
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)