Catalytic enantioselective Minisci-type addition to heteroarenes

Enhancing the potential of enantioselective organocatalysis with light

(2018) Mattia Silvi et al.   NATURE

Carbon annulation of ortho-vinylanilines with dimethyl sulfoxide to access 4-aryl quinolines

(2017) Jin Yuan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereospecific Intramolecular Arylation of 2- and 3-Pyridyl Substituted Alkylamines via Configurationally Stable α-Pyridyl Organolithiums

(2017) Julien Maury et al.   ORGANIC LETTERS

Metal-free C–H alkylation of heteroarenes with alkyltrifluoroborates: a general protocol for 1°, 2° and 3° alkylation

(2017) Jennifer K. Matsui et al.   Chemical Science

Visible Light-Mediated Direct Decarboxylative C–H Functionalization of Heteroarenes

(2017) R. Aleyda Garza-Sanchez et al.   ACS Catalysis

The Enantioselective Dakin-West Reaction

(2016) Raffael C. Wende et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organic Photoredox Catalysis

(2016) Nathan A. Romero et al.   CHEMICAL REVIEWS

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Metal-free, visible-light-mediated, decarboxylative alkylation of biomass-derived compounds

(2016) Johanna Schwarz et al.   GREEN CHEMISTRY

Lewis Acid-Catalyzed Borono-Minisci Reactions of Arylboronic Acids and Heterocycles

(2016) Timothy J. Barker et al.   HETEROCYCLES

Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases

(2016) Chelsea A. Huff et al.   JOURNAL OF ORGANIC CHEMISTRY

A Dual-Catalytic Strategy To Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes

(2016) Jin-Shun Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis

(2016) Zhiwei Zuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents

(2016) T. Qin et al.   SCIENCE

Photoredox-mediated Minisci C–H alkylation of N-heteroarenes using boronic acids and hypervalent iodine

(2016) Guo-Xing Li et al.   Chemical Science

Photoredox/Brønsted Acid Co-Catalysis Enabling Decarboxylative Coupling of Amino Acid and Peptide Redox-Active Esters with N-Heteroarenes

(2016) Wan-Min Cheng et al.   ACS Catalysis

Installing amino acids and peptides on N-heterocycles under visible-light assistance

(2016) Yunhe Jin et al.   Scientific Reports

Constructing Quaternary Carbons from N-(Acyloxy)phthalimide Precursors of Tertiary Radicals Using Visible-Light Photocatalysis

(2015) Gerald Pratsch et al.   JOURNAL OF ORGANIC CHEMISTRY

Facile synthesis and complete characterization of homoleptic and heteroleptic cyclometalated Iridium(III) complexes for photocatalysis

(2015) Anuradha Singh et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synergistic Catalysis of Ionic Brønsted Acid and Photosensitizer for a Redox Neutral Asymmetric α-Coupling of N-Arylaminomethanes with Aldimines

(2015) Daisuke Uraguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphine-Catalyzed Doubly Stereoconvergent γ-Additions of Racemic Heterocycles to Racemic Allenoates: The Catalytic Enantioselective Synthesis of Protected α,α-Disubstituted α-Amino Acid Derivatives

(2015) Marcin Kalek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereospecific Coupling of Boronic Esters with N-Heteroaromatic Compounds

(2015) Josep Llaveria et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alcohols as alkylating agents in heteroarene C–H functionalization

(2015) Jian Jin et al.   NATURE

Direct α-Arylation of Ethers through the Combination of Photoredox-Mediated CH Functionalization and the Minisci Reaction

(2014) Jian Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Radical Addition to Iminium Ions and Cationic Heterocycles

(2014) Johannes Tauber et al.   MOLECULES

Solar Synthesis: Prospects in Visible Light Photocatalysis

(2014) D. M. Schultz et al.   SCIENCE

Cooperative Catalysis through Noncovalent Interactions

(2013) Weijun Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Enantioselective Photoredox Catalysis Enabled by Proton-Coupled Electron Transfer: Development of an Asymmetric Aza-Pinacol Cyclization

(2013) Lydia J. Rono et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical-Based Regioselective C–H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability

(2013) Fionn O’Hara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoredox activation and anion binding catalysis in the dual catalytic enantioselective synthesis of β-amino esters

(2013) Giulia Bergonzini et al.   Chemical Science

Direct C-H Alkylation of Naphthoquinones with Amino Acids Through a Revisited Kochi-Anderson Radical Decarboxylation: Trends in Reactivity and Applications

(2012) Guillaume Naturale et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Enantioselective Synthesis of Highly Substituted Furans by a Copper(II)-Catalyzed Cycloisomerization–Indole Addition Reaction

(2011) Vivek Rauniyar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Minisci Reaction with Simple Alcohols

(2011) Camille A. Correia et al.   ORGANIC LETTERS

Direct Alkylation of Heteroaryls Using Potassium Alkyl- and Alkoxymethyltrifluoroborates

(2011) Gary A. Molander et al.   ORGANIC LETTERS

Innate C-H trifluoromethylation of heterocycles

(2011) Y. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minisci reactions: Versatile CH-functionalizations for medicinal chemists

(2011) Matthew A. J. Duncton   MedChemComm

Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

(2010) Ian B. Seiple et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of TRIP and Analysis of Phosphate Salt Impurities

(2010) Martin Klussmann et al.   SYNLETT

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Practical Synthesis of a Potent Bradykinin B1Antagonist via Enantioselective Hydrogenation of a PyridylN-Acyl Enamide

(2009) Paul D. O’Shea et al.   JOURNAL OF ORGANIC CHEMISTRY