Molecular docking revealed the binding of nucleotide/side inhibitors to Zika viral polymerase solved structures

Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening

(2018) Aryamav Pattnaik et al.   ANTIVIRAL RESEARCH

Applications of computer-aided approaches in the development of hepatitis C antiviral agents

(2017) Aravindhan Ganesan et al.   Expert Opinion on Drug Discovery

Zika virus: novel guanosine derivatives revealed strong binding and possible inhibition of the polymerase

(2017) Abdo A Elfiky   Future Virology

Quantitative structure-activity relationship and molecular docking revealed a potency of anti-hepatitis C virus drugs against human corona viruses

(2017) Abdo A. Elfiky et al.   JOURNAL OF MEDICAL VIROLOGY

Molecular dynamics simulation revealed binding of nucleotide inhibitors to ZIKV polymerase over 444 nanoseconds

(2017) Abdo A. Elfiky et al.   JOURNAL OF MEDICAL VIROLOGY

Molecular detection of Zika virus in blood and RNA load determination during the French Polynesian outbreak

(2017) Didier Musso et al.   JOURNAL OF MEDICAL VIROLOGY

The structure of Zika virus NS5 reveals a conserved domain conformation

(2017) Boxiao Wang et al.   Nature Communications

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

(2017) Andre S. Godoy et al.   Nature Communications

Crystal structure of full-lengthZika virusNS5 protein reveals a conformation similar toJapanese encephalitis virusNS5

(2017) Anup K. Upadhyay et al.   Acta Crystallographica Section F-Structural Biology Communications

Zika virus outbreak and the case for building effective and sustainable rapid diagnostics laboratory capacity globally

(2016) Alimuddin Zumla et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Potential use of saliva samples to diagnose Zika virus infection

(2016) L.B. Tauro et al.   JOURNAL OF MEDICAL VIROLOGY

Zika viral polymerase inhibition using anti-HCV drugs both in market and under clinical trials

(2016) Abdo A. Elfiky   JOURNAL OF MEDICAL VIROLOGY

IDX-184 is a superior HCV direct-acting antiviral drug: a QSAR study

(2016) Abdo A. Elfiky et al.   MEDICINAL CHEMISTRY RESEARCH

Zika Virus Associated with Microcephaly

(2016) Jernej Mlakar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika virus drug targets: a missing link in drug design and discovery – a route map to fill the gap

(2016) Pritika Ramharack et al.   RSC Advances

2′-Methylguanosine Prodrug (IDX-184), Phosphoramidate Prodrug (Sofosbuvir), Diisobutyryl Prodrug (R7128) Are Better Than Their Parent Nucleotides and Ribavirin in Hepatitis C Virus Inhibition: A Molecular Modeling Study

(2015) Abdo A. Elfiky et al.   Journal of Computational and Theoretical Nanoscience

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Structural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic Implications

(2015) Rodrigo Jácome et al.   PLoS One

RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory Mechanisms

(2015) Cristina Ferrer-Orta et al.   Viruses-Basel

Molecular modeling and residue interaction network studies on the mechanism of binding and resistance of the HCV NS5B polymerase mutants to VX-222 and ANA598

(2014) Weiwei Xue et al.   ANTIVIRAL RESEARCH

Rapid spread of emerging Zika virus in the Pacific area

(2014) D. Musso et al.   CLINICAL MICROBIOLOGY AND INFECTION

Pharmacokinetics and Pharmacodynamics of Setrobuvir, an Orally Administered Hepatitis C Virus Non-Nucleoside Analogue Inhibitor

(2014) Navita L. Mallalieu et al.   CLINICAL THERAPEUTICS

Daclatasvir plus sofosbuvir for HCV infection: An oral combination therapy with high antiviral efficacy

(2014) Tarik Asselah   JOURNAL OF HEPATOLOGY

Zika Virus in Gabon (Central Africa) – 2007: A New Threat from Aedes albopictus?

(2014) Gilda Grard et al.   PLoS Neglected Tropical Diseases

Molecular Modeling Comparison of the Performance of NS5b Polymerase Inhibitor (PSI-7977) on Prevalent HCV Genotypes

(2013) Abdo A. Elfiky et al.   PROTEIN JOURNAL

Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure–activity and resistance relationships; different scaffolds and mutations

(2012) Abdelrahman S. Mayhoub   BIOORGANIC & MEDICINAL CHEMISTRY

Correlation to Protein Conformation of Wide-Angle X-ray Scatter Parameters

(2010) Wael M. Elshemey et al.   PROTEIN JOURNAL

Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B

(2010) Megan H. Powdrill et al.   Viruses-Basel

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY