SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice

Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice

(2017) Steven Hutchens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production

(2017) Chunyi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity

(2017) Wen Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Metal Transporter Zip14 ( Slc39a14 ) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity

(2017) Tolunay Beker Aydemir et al.   JOURNAL OF NEUROSCIENCE

Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

(2017) Yongjuan Xin et al.   Cell Discovery

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10 , a Manganese Transporter in Man

(2016) Karin Tuschl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structural Elements in the Transmembrane and Cytoplasmic Domains of the Metal Transporter SLC30A10 Are Required for Its Manganese Efflux Activity

(2016) Charles E. Zogzas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter

(2016) Yukina Nishito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Performance of Male and Female C57BL/6J Mice on Motor and Cognitive Tasks Commonly Used in Pre-Clinical Traumatic Brain Injury Research

(2016) Laura B. Tucker et al.   JOURNAL OF NEUROTRAUMA

Mechanisms of divalent metal toxicity in affective disorders

(2016) Archita Venugopal Menon et al.   TOXICOLOGY

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia

(2016) Karin Tuschl et al.   Nature Communications

Neuroimaging identifies increased manganese deposition in infants receiving parenteral nutrition

(2015) Judy L Aschner et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese

(2015) Ali Shawki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation

(2015) Inga Wessels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Manganese Is Essential for Neuronal Health

(2015) Kyle J. Horning et al.   Annual Review of Nutrition

SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

(2015) Supak Jenkitkasemwong et al.   Cell Metabolism

Manganese transport disorder: NovelSLC30A10mutations and early phenotypes

(2015) Marialuisa Quadri et al.   MOVEMENT DISORDERS

Developmental exposure to manganese induces lasting motor and cognitive impairment in rats

(2015) Tanara V. Peres et al.   NEUROTOXICOLOGY

Manganese-induced neurotoxicity: from C. elegans to humans

(2015) Pan Chen et al.   Toxicology Research

Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson’s disease by laser ablation inductively coupled plasma mass spectrometry

(2014) Sorina Boaru et al.   BMC NEUROSCIENCE

Manganese Encephalopathy among Ephedron Abusers-Case Reports

(2014) Justyna Janocha-Litwin et al.   JOURNAL OF NEUROIMAGING

SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

(2014) D. Leyva-Illades et al.   JOURNAL OF NEUROSCIENCE

Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese

(2014) Jerome A. Roth   NEUROTOXICOLOGY

Manganese accumulation in bone following chronic exposure in rats: Steady-state concentration and half-life in bone

(2014) Stefanie L. O’Neal et al.   TOXICOLOGY LETTERS

Pathophysiology of the Belgrade rat

(2014) Tania Veuthey et al.   Frontiers in Pharmacology

ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders

(2013) H. Nam et al.   HAEMATOLOGICA

Manganism in the 21st century: The Hanninen lecture

(2013) Brad A. Racette   NEUROTOXICOLOGY

Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains

(2013) Attila D. Kovács et al.   Scientific Reports

Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver Disease

(2012) Marialuisa Quadri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Zinc Transporter Zip14 Influences c-Met Phosphorylation and Hepatocyte Proliferation During Liver Regeneration in Mice

(2012) Tolunay Beker Aydemir et al.   GASTROENTEROLOGY

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

(2012) Anthony C. Illing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

Animal Models of Neurological Disorders

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

Zinc Transporter ZIP14 Functions in Hepatic Zinc, Iron and Glucose Homeostasis during the Innate Immune Response (Endotoxemia)

(2012) Tolunay Beker Aydemir et al.   PLoS One

Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron

(2011) Jorge J. Pinilla-Tenas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Zinc Transporter SLC39A14/ZIP14 Controls G-Protein Coupled Receptor-Mediated Signaling Required for Systemic Growth

(2011) Shintaro Hojyo et al.   PLoS One

In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese

(2010) Ulrike Dydak et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Taming anxiety in laboratory mice

(2010) Jane L Hurst et al.   NATURE METHODS

Tests to assess motor phenotype in mice: a user's guide

(2009) Simon P. Brooks et al.   NATURE REVIEWS NEUROSCIENCE

Is manganese an essential supplement for parenteral nutrition?

(2008) Ines J Hardy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders

(2007) Dixin Wang et al.   TOXICOLOGY LETTERS