Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production

Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14

(2018) Somshuvra Mukhopadhyay   NEUROTOXICOLOGY

Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice

(2017) Steven Hutchens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity

(2017) Wen Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Metal Transporter Zip14 ( Slc39a14 ) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity

(2017) Tolunay Beker Aydemir et al.   JOURNAL OF NEUROSCIENCE

Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis

(2017) Zhidan Xia et al.   PLoS Genetics

Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

(2017) Yongjuan Xin et al.   Cell Discovery

Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants

(2016) Giancarlo Chesi et al.   HEPATOLOGY

Structural Elements in the Transmembrane and Cytoplasmic Domains of the Metal Transporter SLC30A10 Are Required for Its Manganese Efflux Activity

(2016) Charles E. Zogzas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter

(2016) Yukina Nishito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia

(2016) Karin Tuschl et al.   Nature Communications

SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation

(2015) Julien H. Park et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8

(2015) Kym M. Boycott et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cation Diffusion Facilitator family: Structure and function

(2015) Olga Kolaj-Robin et al.   FEBS LETTERS

The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism

(2015) Taiho Kambe et al.   PHYSIOLOGICAL REVIEWS

A Conserved Structural Motif Mediates Retrograde Trafficking of Shiga Toxin Types 1 and 2

(2015) Andrey S. Selyunin et al.   TRAFFIC

Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity

(2015) Sarah N. Le et al.   PLoS One

Pathology of inherited manganese transporter deficiency

(2014) Mirna Lechpammer et al.   ANNALS OF NEUROLOGY

Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

(2014) Elena V. Polishchuk et al.   DEVELOPMENTAL CELL

SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

(2014) D. Leyva-Illades et al.   JOURNAL OF NEUROSCIENCE

Relationship between blood manganese levels and children's attention, cognition, behavior, and academic performance—A nationwide cross-sectional study

(2013) Soo-Young Bhang et al.   ENVIRONMENTAL RESEARCH

ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders

(2013) H. Nam et al.   HAEMATOLOGICA

The SLC39 family of zinc transporters

(2013) Jeeyon Jeong et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC30 family of zinc transporters – A review of current understanding of their biological and pathophysiological roles

(2013) Liping Huang et al.   MOLECULAR ASPECTS OF MEDICINE

Shiga toxin–binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms

(2013) Somshuvra Mukhopadhyay et al.   MOLECULAR BIOLOGY OF THE CELL

Early life versus lifelong oral manganese exposure differently impairs skilled forelimb performance in adult rats

(2013) Stephane A. Beaudin et al.   NEUROTOXICOLOGY AND TERATOLOGY

Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver Disease

(2012) Marialuisa Quadri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10 , a Manganese Transporter in Man

(2012) Karin Tuschl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Physiologic implications of metal-ion transport by ZIP14 and ZIP8

(2012) Supak Jenkitkasemwong et al.   BIOMETALS

Parkinsonism in cirrhosis: pathogenesis and current therapeutic options

(2012) Roger F. Butterworth   METABOLIC BRAIN DISEASE

Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis

(2012) Helen J. Bosomworth et al.   Metallomics

Tremor, olfactory and motor changes in Italian adolescents exposed to historical ferro-manganese emission

(2012) Roberto G. Lucchini et al.   NEUROTOXICOLOGY

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

(2012) S. Mukhopadhyay et al.   SCIENCE

Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron

(2011) Jorge J. Pinilla-Tenas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reduced Glutathione Enhances Fertility of Frozen/Thawed C57BL/6 Mouse Sperm after Exposure to Methyl-Beta-Cyclodextrin1

(2011) Toru Takeo et al.   BIOLOGY OF REPRODUCTION

Hidden Costs of Energy: Unpriced Consequences of Energy Production and Use by the National Research Council . Washington, DC:National Academies Press, 2010. 473 pp. ISBN: 978-0-309-14640-1, $47  

(2011) Maximilian Auffhammer   ENVIRONMENTAL HEALTH PERSPECTIVES

Manganese Exposure from Drinking Water and Children’s Classroom Behavior in Bangladesh

(2011) Khalid Khan et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Manganese exposure from drinking water and children's academic achievement

(2011) Khalid Khan et al.   NEUROTOXICOLOGY

Intellectual Function in Mexican Children Living in a Mining Area and Environmentally Exposed to Manganese

(2010) Horacio Riojas-Rodríguez et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Early Postnatal Blood Manganese Levels and Childrenʼs Neurodevelopment

(2010) Birgit Claus Henn et al.   EPIDEMIOLOGY

Manganese-induced Trafficking and Turnover of the cis-Golgi Glycoprotein GPP130

(2010) Somshuvra Mukhopadhyay et al.   MOLECULAR BIOLOGY OF THE CELL

A mouse knockout library for secreted and transmembrane proteins

(2010) Tracy Tang et al.   NATURE BIOTECHNOLOGY

Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity

(2010) S. Mukhopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trace elements status in multinodular goiter

(2009) Belma Giray et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

Preweaning manganese exposure causes hyperactivity, disinhibition, and spatial learning and memory deficits associated with altered dopamine receptor and transporter levels

(2009) Cynthia H. Kern et al.   SYNAPSE

Hepatic cirrhosis, dystonia, polycythaemia and hypermanganesaemia—A new metabolic disorder

(2008) Karin Tuschl et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

(2008) K. Girijashanker et al.   MOLECULAR PHARMACOLOGY