Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane

Shaping mitochondrial dynamics: The role of cAMP signalling

(2018) Giulietta Di Benedetto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Experimental and mathematical analysis of cAMP nanodomains

(2017) Christian Lohse et al.   PLoS One

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

(2016) Mark Richards et al.   CARDIOVASCULAR RESEARCH

The Dark Side of Cell Signaling: Positive Roles for Negative Regulators

(2016) Mark A. Lemmon et al.   CELL

Dysregulation of Neuronal Ca 2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States

(2016) Hege E. Larsen et al.   JOURNAL OF NEUROSCIENCE

Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease

(2016) Hege E. Larsen et al.   Scientific Reports

Mechanisms Restricting Diffusion of Intracellular cAMP

(2016) Shailesh R. Agarwal et al.   Scientific Reports

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

(2015) Anna Zoccarato et al.   CIRCULATION RESEARCH

Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

(2015) Jeffrey Klarenbeek et al.   PLoS One

Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes

(2014) Zeineb Haj Slimane et al.   CARDIOVASCULAR RESEARCH

cAMP signaling in subcellular compartments

(2014) Konstantinos Lefkimmiatis et al.   PHARMACOLOGY & THERAPEUTICS

Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides

(2014) Oliver Lomas et al.   PHYSIOLOGY

Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin

(2014) Sohum Mehta et al.   eLife

Mitochondrial Ca2+ Uptake Induces Cyclic AMP Generation in the Matrix and Modulates Organelle ATP Levels

(2013) Giulietta Di Benedetto et al.   Cell Metabolism

The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics

(2013) Konstantinos Lefkimmiatis et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of cyclic AMP compartmentation revealed by computational models

(2013) Jeffrey J. Saucerman et al.   JOURNAL OF GENERAL PHYSIOLOGY

Function and regulation of serine/threonine phosphatases in the healthy and diseased heart

(2013) Jordi Heijman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling

(2013) Jason H. Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interrogating cAMP-dependent Kinase Signaling in Jurkat T Cells via a Protein Kinase A Targeted Immune-precipitation Phosphoproteomics Approach

(2013) Piero Giansanti et al.   MOLECULAR & CELLULAR PROTEOMICS

Creating Order from Chaos: Cellular Regulation by Kinase Anchoring

(2012) John D. Scott et al.   Annual Review of Pharmacology and Toxicology

Computational Analysis of the Regulation of EGFR by Protein Tyrosine Phosphatases

(2012) Calixte S. Monast et al.   BIOPHYSICAL JOURNAL

Anchored phosphatases modulate glucose homeostasis

(2012) Simon A Hinke et al.   EMBO JOURNAL

Termination and activation of store-operated cyclic AMP production

(2012) Isabella Maiellaro et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP

(2012) Vedangi Sample et al.   Nature Chemical Biology

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AKAP Phosphatase Complexes in the Heart

(2011) John M Redden et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

AKAPs: The architectural underpinnings of local cAMP signaling

(2011) Michael D. Kritzer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

(2011) C. K. Means et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1

(2011) Ronald A. Merrill et al.   PLOS BIOLOGY

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation

(2009) Rebeca Acin-Perez et al.   Cell Metabolism

“cAMP Sponge”: A Buffer for Cyclic Adenosine 3′, 5′-Monophosphate

(2009) Konstantinos Lefkimmiatis et al.   PLoS One

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

(2008) Giulietta Di Benedetto et al.   CIRCULATION RESEARCH

A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function

(2008) Marco Spinazzi et al.   HUMAN MOLECULAR GENETICS

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA