Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues

Epigenetic inactivation of FAT4 contributes to gastric field cancerization

(2016) Satoshi Yoshida et al.   Gastric Cancer

High impact of methylation accumulation on metachronous gastric cancer: 5-year follow-up of a multicentre prospective cohort study

(2016) Masahiro Maeda et al.   GUT

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

(2016) Maria Secrier et al.   NATURE GENETICS

Epigenetic Determinants of Cancer

(2016) Stephen B. Baylin et al.   Cold Spring Harbor Perspectives in Biology

DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

(2016) Andrew E Teschendorff et al.   Nature Communications

Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study

(2015) Taichi Shimazu et al.   CARCINOGENESIS

The stomach in health and disease

(2015) R H Hunt et al.   GUT

Causality and Chance in the Development of Cancer

(2015) Lucio Luzzatto et al.   NEW ENGLAND JOURNAL OF MEDICINE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer

(2015) Andrew E. Teschendorff et al.   JAMA Oncology

Accumulation of Somatic Mutations in TP53 in Gastric Epithelium With Helicobacter pylori Infection

(2014) Takahiro Shimizu et al.   GASTROENTEROLOGY

Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study

(2014) Kiyoshi Asada et al.   GUT

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Identification of genomic alterations in oesophageal squamous cell cancer

(2014) Yongmei Song et al.   NATURE

Genetic landscape of esophageal squamous cell carcinoma

(2014) Yi-Bo Gao et al.   NATURE GENETICS

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

(2014) Kai Wang et al.   NATURE GENETICS

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Esophageal Carcinoma

(2014) Anil K. Rustgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Deciphering Signatures of Mutational Processes Operative in Human Cancer

(2013) Ludmil B. Alexandrov et al.   Cell Reports

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

(2012) Andrew E. Teschendorff et al.   BIOINFORMATICS

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

(2012) Zhi Jiang Zang et al.   NATURE GENETICS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation

(2012) Andrew E Teschendorff et al.   Genome Medicine

Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic Markers

(2011) Y.-C. Lee et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Molecular Pathways: Involvement of Helicobacter pylori-Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk and Exposure Markers

(2011) T. Ushijima et al.   CLINICAL CANCER RESEARCH

Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells

(2010) T. Niwa et al.   CANCER RESEARCH

The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history

(2009) Daiji Oka et al.   CANCER

Aberrant DNA methylation in contrast with mutations

(2009) Toshikazu Ushijima et al.   CANCER SCIENCE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE