Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival

(2017) Josef Finsterer et al.   EPILEPSY RESEARCH

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

(2017) Hoi-Shan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

(2017) Akihisa Okamoto et al.   Scientific Reports

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

(2016) Gang Cheng et al.   CANCER RESEARCH

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

(2016) Dan Y. Gui et al.   Cell Metabolism

Valproic Acid Promotes Human Glioma U87 Cells Apoptosis and Inhibits Glycogen Synthase Kinase-3β Through ERK/Akt Signaling

(2016) Chi Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Continuous monitoring of caspase-3 activation induced by propofol in developing mouse brain

(2016) Ayumi Konno et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Propofol Is Mitochondrion-Toxic and May Unmask a Mitochondrial Disorder

(2016) Josef Finsterer et al.   JOURNAL OF CHILD NEUROLOGY

Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231

(2016) Chao Meng et al.   ONCOLOGY REPORTS

The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells

(2016) Akihisa Okamoto et al.   BMC Anesthesiology

Possible Pathogenic Mechanism of Propofol Infusion Syndrome Involves Coenzyme Q

(2015) Arnaud Vincent Vanlander et al.   ANESTHESIOLOGY

Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides

(2015) Satoshi Matsuzaki et al.   BIOCHEMISTRY

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

(2015) Marleen Forkink et al.   Redox Biology

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

(2014) Alba Luengo et al.   BMC BIOLOGY

Propofol Compared with Isoflurane Inhibits Mitochondrial Metabolism in Immature Swine Cerebral Cortex

(2014) Masaki Kajimoto et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

The Target of Metformin in Type 2 Diabetes

(2014) Ele Ferrannini   NEW ENGLAND JOURNAL OF MEDICINE

Propofol induces endoplasmic reticulum (ER) stress and apoptosis in lung cancer cell H460

(2014) Wen-Yao Cui et al.   TUMOR BIOLOGY

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Anesthetic considerations in patients with mitochondrial defects

(2013) Julie Niezgoda et al.   PEDIATRIC ANESTHESIA

Mitochondrial Complex I Plays an Essential Role in Human Respirasome Assembly

(2012) David Moreno-Lastres et al.   Cell Metabolism

Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2

(2012) Nanduri R. Prabhakar et al.   PHYSIOLOGICAL REVIEWS

A novel function of mtDNA: its involvement in metastasis

(2010) Kaori Ishikawa et al.   Annals of the New York Academy of Sciences

Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells

(2010) Mutsumi Yokota et al.   FEBS LETTERS

Sevoflurane and propofol depolarize mitochondria in rat and human cerebrocortical synaptosomes by different mechanisms

(2009) R. BAINS et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

(2009) Nobuko Koshikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis

(2008) Kaori Ishikawa et al.   FEBS LETTERS

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE