标题
Genome scale metabolic models as tools for drug design and personalized medicine
作者
关键词
Drug metabolism, Enzyme metabolism, Enzymes, Cell metabolism, Therapeutic window method, Enzyme inhibitors, Gene expression, Protein metabolism
出版物
PLoS One
Volume 13, Issue 1, Pages e0190636
出版商
Public Library of Science (PLoS)
发表日期
2018-01-06
DOI
10.1371/journal.pone.0190636
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Could drugs inhibiting the mevalonate pathway also target cancer stem cells?
- (2016) Wirginia Likus et al. DRUG RESISTANCE UPDATES
- KEGG as a reference resource for gene and protein annotation
- (2015) Minoru Kanehisa et al. NUCLEIC ACIDS RESEARCH
- BioModels: ten-year anniversary
- (2014) Vijayalakshmi Chelliah et al. NUCLEIC ACIDS RESEARCH
- RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells
- (2014) Blanca E. Himes et al. PLoS One
- Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer
- (2014) Keren Yizhak et al. eLife
- COBRApy: COnstraints-Based Reconstruction and Analysis for Python
- (2013) Ali Ebrahim et al. BMC Systems Biology
- Latest developments in molecular docking: 2010-2011 in review
- (2013) Elizabeth Yuriev et al. JOURNAL OF MOLECULAR RECOGNITION
- Integration of clinical data with a genome-scale metabolic model of the human adipocyte
- (2013) A. Mardinoglu et al. Molecular Systems Biology
- A community-driven global reconstruction of human metabolism
- (2013) Ines Thiele et al. NATURE BIOTECHNOLOGY
- Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
- (2013) Sergio Bordel Scientific Reports
- Metabolic and protein interaction sub-networks controlling the proliferation rate of cancer cells and their impact on patient survival
- (2013) Amir Feizi et al. Scientific Reports
- Pharmacogenomics Knowledge for Personalized Medicine
- (2012) M Whirl-Carrillo et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Identification of Ligand Templates using Local Structure Alignment for Structure-Based Drug Design
- (2012) Hui Sun Lee et al. Journal of Chemical Information and Modeling
- Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
- (2012) M. Jain et al. SCIENCE
- Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT
- (2012) Rasmus Agren et al. PLoS Computational Biology
- Old friends in new guise: repositioning of known drugs with structural bioinformatics
- (2011) V. J. Haupt et al. BRIEFINGS IN BIOINFORMATICS
- Predicting selective drug targets in cancer through metabolic networks
- (2011) O. Folger et al. Molecular Systems Biology
- Caffeine inhibits cell proliferation and regulates PKA/GSK3β pathways in U87MG human glioma cells
- (2011) Bo Mi Ku et al. MOLECULES AND CELLS
- Targeting cancer metabolism: a therapeutic window opens
- (2011) Matthew G. Vander Heiden NATURE REVIEWS DRUG DISCOVERY
- Open Babel: An open chemical toolbox
- (2011) Noel M O'Boyle et al. Journal of Cheminformatics
- Sampling the Solution Space in Genome-Scale Metabolic Networks Reveals Transcriptional Regulation in Key Enzymes
- (2010) Sergio Bordel et al. PLoS Computational Biology
- FINDSITELHM: A Threading-Based Approach to Ligand Homology Modeling
- (2009) Michal Brylinski et al. PLoS Computational Biology
- Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production
- (2009) Caroline Colijn et al. PLoS Computational Biology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started