Article
Multidisciplinary Sciences
Pouya Dini, Theodore Kalbfleisch, Jose M. Uribe-Salazar, Mariano Carossino, Hossam El-Sheikh Ali, Shavahn C. Loux, Alejandro Esteller-Vico, Jamie K. Norris, Lakshay Anand, Kirsten E. Scoggin, Carlos M. Rodriguez Lopez, James Breen, Ernest Bailey, Peter Daels, Barry A. Ball
Summary: Most autosomal genes in the placenta show a biallelic expression pattern, while some exhibit allele-specific transcription depending on the parental origin of the chromosomes. Parentally expressed genes in equine pregnancy influence resource allocation between fetus and mother, with maternally expressed genes tending to shorten gestation and paternally expressed genes extending it. This study provides fundamental insights into parental gene expression during equine pregnancy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Obstetrics & Gynecology
Prachi Kochhar, Pratibha Dwarkanath, Gayatri Ravikumar, Annamma Thomas, Julian Crasta, Tinku Thomas, Anura Kurpad, Arpita Mukhopadhyay
Summary: The study found associations between the expression of miR-517-5p and miR-518f-5p with newborn parameters and target genes, indicating their potential roles in fetal growth restriction pathophysiology.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Chemistry, Medicinal
Amu Gubu, Wenbo Su, Xiaoran Zhao, Xueli Zhang, Xinli Fan, Jing Wang, Qian Wang, Xinjing Tang
Summary: Circular AMOs are designed to effectively inhibit microRNA functions with high target specificity and low off-target effects. Compared with linear AMOs, circular AMOs can more effectively reduce the amount of carcinogenic microRNAs and upregulate expression levels of antitumor proteins.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Peng Xu, Yeling Ma, Hongyu Wu, Yan-Ling Wang
Summary: Disorders in placental cells are closely associated with adverse pregnancy outcomes, and microRNAs in the placenta play important roles in regulating placental cell behaviors. Placental exosome miRNAs can potentially target maternal cells for intercellular communication between the mother and fetus, serving as novel biomarkers for predicting diseases such as preeclampsia. The transfer of placental miRNAs through exosomes may offer targeted strategies for diagnosing, prognosing, or treating preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Madiha Zaynab, Jiaofeng Peng, Yasir Sharif, Mohammed Albaqami, Rashid Al-Yahyai, Mahpara Fatima, Muhammad Azhar Nadeem, Khalid Ali Khan, Saqer S. Alotaibi, Ibrahim A. Alaraidh, Hassan O. Shaikhaldein, Shuangfei Li
Summary: This study conducted a comprehensive analysis of DDP proteins in the potato genome, identifying 10 DDP genes and studying their characteristics in terms of phylogenetics, gene duplication, expression profiles, and promoter regions involved in stress response. The research revealed that StDDP genes were distributed across different clades, and exhibited various expression patterns in response to heat stress and salt stress. Real-time qPCR results indicated that StDDPs played significant roles in potato growth and development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Irina Gilyazova, Elizaveta Ivanova, Adel Izmailov, Ildar Sharifgaliev, Alexandra Karunas, Elena Pudova, Anastasiya Kobelyatskaya, Gulshat Gilyazova, Angelina Izmailova, Valentin Pavlov, Elza Khusnutdinova
Summary: A study found that there are nine dysregulated miRNAs in ccRCC tumor tissue, which can distinguish different stages of the tumor and normal renal tissue. The combination of miRNA-210, miRNA-483-5p, miRNA-455, and miRNA-200c can differentiate low and high TNM ccRCC stages. These findings suggest the important role of miRNA in the pathogenesis of ccRCC, but further research is needed for validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria A. Gomez-Munoz, Diana Aguilar-Morante, Ana Colmenero-Repiso, Aida Amador-Alvarez, Monica Ojeda-Puertas, Juan Antonio Cordero Varela, Ismael Rodriguez-Prieto, Ricardo Pardal, Francisco M. Vega
Summary: Neuroblastoma is a pediatric tumor with high heterogeneity and poor outcome. Patient-derived xenografts (PDXs) have been found to be useful models for studying neuroblastoma biology. In this study, we analyzed consecutive PDX passages to identify potential changes and correlations with neuroblastoma aggressiveness. We observed changes in gene expression and identified new genes and miRNAs that could be used for patient stratification and understanding tumor aggressiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Fernanda Alvarado-Flores, Tomoko Kaneko-Tarui, William Beyer, Jacqueline Katz, Tianjiao Chu, Patrick Catalano, Yoel Sadovsky, Marie-France Hivert, Perrie O'Tierney-Ginn
Summary: Maternal insulin resistance during late pregnancy is associated with the expression of placental miRNA-3940-3p, suggesting a potential regulatory role of this miRNA in modulating maternal insulin resistance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Microbiology
Rachel Hood Edwards, Nancy Raab-Traub
Summary: This study evaluated the impact of EBV and BART lncRNAs on cellular expression, showing that they induce changes in cellular miRs and lncRNAs. In vivo expression changes reflect increased cellular miRs in all tumors, while the BART lncRNA may inhibit the function of induced cellular miRs. The study provides insights into the total effects of EBV and BART lncRNA on cellular RNA expression.
Article
Environmental Sciences
Lauren A. Eaves, Catherine M. Bulka, Julia E. Rager, Amaree J. Gardner, Aubrey L. Galusha, Patrick J. Parsons, T. Michael O'Shea, Rebecca C. Fry
Summary: Prenatal exposure to toxic metals is associated with adverse birth and later-in-life outcomes. This study aimed to investigate the relationship between metal concentrations in the umbilical cord and altered gene expression networks in placental tissue. The results showed that certain metals, such as lead and cadmium, were associated with changes in gene expression and the dysregulation of important pathways in the placenta. These findings provide insights into the potential mechanisms underlying metal-induced diseases.
Article
Developmental Biology
Monica Strawn, Ananya Samal, Md Bodruzzaman Sarker, Pramod Dhakal, Susanta K. Behura
Summary: The study reveals that miRNAs play crucial roles in regulating gene expression in both the placenta and fetal brain, with fetal sex influencing miRNA regulation between the two. Functional annotation of known target genes shows that these miRNAs are significantly enriched in specific signaling and transporter pathways.
Article
Biochemistry & Molecular Biology
Zhao Li, Kaikai Mao, Ruoheng Jin, Tingwei Cai, Yao Qin, Yunhua Zhang, Shun He, Kangsheng Ma, Hu Wan, Xuexiang Ren, Jianhong Li
Summary: The study found that miRNA novel_268 is involved in the resistance of Nilaparvata lugens to nitenpyram and clothianidin by targeting the ABC transporter NlABCG3. These results provide more insights into the transcriptional regulation of ABC transporters in the insecticide resistance of N. lugens.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Hematology
Susanne Lux, Tamara J. Blaette, Bernhard Gillissen, Antje Richter, Sibylle Cocciardi, Sabrina Skambraks, Klaus Schwarz, Hubert Schrezenmeier, Hartmut Doehner, Konstanze Doehner, Anna Dolnik, Lars Bullinger
Summary: The study reveals significant differential expression of circRNAs between AML patients and healthy HSPCs, with many circRNAs transcribed from genes implicated in leukemia biology. CircBCL11B is identified as a leukemia-associated circRNA exclusively expressed in AML patients, associated with a T-cell-like gene expression signature, and playing a role in AML pathogenesis by affecting leukemic cell proliferation and survival. This research provides valuable insights into circRNA expression changes in leukemic transformation and offers potential novel pathway dependencies for AML therapy.
Article
Biochemistry & Molecular Biology
Olaf Uhl, Rohan M. Lewis, Birgit Hirschmugl, Sarah Crozier, Hazel Inskip, Antonio Gazquez, Nicholas C. Harvey, Cyrus Cooper, Gernot Desoye, Berthold Koletzko, Christian Wadsack, Hans Demmelmair, Keith M. Godfrey
Summary: The study found specific differences in polar-lipid composition and related gene expression in placentas of different sizes. These differences in lipid composition were associated with birth weight and neonatal lean mass, indicating that placental lipid composition may influence prenatal lean mass accretion.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Veterinary Sciences
Lei Zhang, Linlin Chen, Hongtao Zhang, Hongbin Si, Xianyong Liu, Xun Suo, Dandan Hu
Summary: This study characterized the RNA silencing machinery and miRNA expression profiles in different stages of Eimeria tenella. The miRNA expression was found to regulate gene expression, chromatin binding, and protein phosphorylation. This study provides insights into the regulation of gene expression during the parasite life cycle in apicomplexan parasites.
FRONTIERS IN VETERINARY SCIENCE
(2022)