Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy

In placental mammals, reproductive success, and maternal-fetal health substantially depend on a well-being placenta, the interface between the fetus and the mother. Disorders in placental cells are tightly associated with adverse pregnancy outcomes including preeclampsia (PE), fetal growth restriction, etc. MicroRNAs (miRNAs) represent small non-coding RNAs that regulate post-transcriptional gene expression and are integral to a wide range of healthy or diseased cellular proceedings. Numerous miRNAs have been detected in human placenta and increasing evidence is revealing their important roles in regulating placental cell behaviors. Recent studies indicate that placenta-derived miRNAs can be released to the maternal circulation via encapsulating into the exosomes, and they potentially target various maternal cells to provide a hormone-like means of intercellular communication between the mother and the fetus. These placental exosome miRNAs are attracting more and more attention due to their differential expression in pregnant complications, which may provide novel biomarkers for prediction of the diseases. In this review, we briefly summarize the current knowledge and the perspectives of the placenta-derived miRNAs, especially the exosomal transfer of placental miRNAs and their pathophysiological relevance to PE. The possible exosomal-miRNA-targeted strategies for diagnosis, prognosis or therapy of PE are highlighted.

Automated summary

Disorders in placental cells are closely associated with adverse pregnancy outcomes, and microRNAs in the placenta play important roles in regulating placental cell behaviors. Placental exosome miRNAs can potentially target maternal cells for intercellular communication between the mother and fetus, serving as novel biomarkers for predicting diseases such as preeclampsia. The transfer of placental miRNAs through exosomes may offer targeted strategies for diagnosing, prognosing, or treating preeclampsia.