Article
Pharmacology & Pharmacy
Peramaiyan Rajendran, Duaa Althumairy, Mohammad Bani-Ismail, Gamal M. Bekhet, Emad A. Ahmed
Summary: In this study, it was found that long-term exposure to aluminum chloride caused neurotoxicity and oxidative stress in mice. However, the natural furanocoumarin compound isoimperatorin (IMP) derived from plants such as lemon and lime oils was shown to have potential in combating this toxicity. IMP improved the damage caused by aluminum by reducing oxidative stress and regulating the inflammatory response, suggesting that it could be a promising treatment option for neurotoxicity and neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Saeed Samarghandian
Summary: Astaxanthin (ATX) is a red pigment carotenoid found in shrimp, salmon, crab, and asteroidean, with proven antioxidant efficacy. Nrf2 plays a crucial role in mediating the various protective effects of ATX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Andreea Ioana Inceu, Maria Adriana Neag, Adrian Catinean, Corina Ioana Bocsan, Cristian Ioan Craciun, Carmen Stanca Melincovici, Dana Maria Muntean, Madalin Mihai Onofrei, Raluca Maria Pop, Anca Dana Buzoianu
Summary: Spore-forming probiotic bacteria may have a beneficial effect on dexamethasone-induced metabolic disturbances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
H. S. Rohith, Prakash Motiram Halami
Summary: The study evaluates the effects of a combination of Bacillus licheniformis and Bifidobacterium breve on the gene expression and immune response of HT-29 cells. The combination of these probiotic bacteria showed anti-inflammatory activity and improved the gastrointestinal environment, making it a promising treatment for intestinal disorders.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Cell Biology
Lei Lei, Jianan Zhang, Eric A. Decker, Guodong Zhang
Summary: This review discusses the common feature of redox stress in gut disorders and its impact on the development of inflammatory bowel disease (IBD) and colorectal cancer (CRC), emphasizing the critical role of lipid-derived electrophiles in the pathogenesis of these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Tao Wang, Panpan Wang, Wupeng Ge, Chao Shi, Gongnian Xiao, Xin Wang, Xin Lu
Summary: This study found that a multi-strain probiotics mixture could significantly inhibit tumorigenesis and inflammatory response, improve intestinal barrier function, and alleviate oxidative stress in azoxymethane/dextran sulfate sodium-induced CRC mice by mediating gut microbiota.
Article
Environmental Sciences
Shekh Mohammad Afzal, Abul Vafa, Summya Rashid, Preeti Barnwal, Ayaz Shahid, Alpa Shree, Johirul Islam, Nemat Ali, Sarwat Sultana
Summary: Hesperidin effectively protects against DMH-induced colon toxicity by modulating oxidative stress, inflammation, and apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra Kozlowska, Tomasz Dzierzanowski
Summary: Anthocyanins play a promising role in regulating inflammation and activating antioxidant defenses. Clinical studies have shown that anthocyanins supplementation can regulate inflammatory markers in both healthy individuals and those with chronic diseases. However, long-term clinical trials are needed to quantify the progression of inflammation effectively.
Review
Food Science & Technology
Kasra Jahankhani, Niloofar Taghipour, Mohammad Mashhadi Rafiee, Maryam Nikoonezhad, Mahshid Mehdizadeh, Nariman Mosaffa
Summary: Trace elements and other micronutrients have a crucial role in growth, health, and immune system function. Estimating the serum levels of trace elements in hematologic malignancy patients can determine the severity of the tumor. In addition to conventional medicine, the use of dietary supplements, such as trace minerals, can enhance recovery and reduce inflammation in diseases like multiple myeloma.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lei Lei, Jun Yang, Jianan Zhang, Guodong Zhang
Summary: Oxidative stress is a significant contributor to the pathogenesis of colorectal cancer, with the lipid peroxidation product EKODE playing a crucial role in colonic inflammation and colon tumorigenesis.
Review
Cell Biology
Yang Sun, Yantao Yang, Shasha Liu, Songwei Yang, Chen Chen, Meiyu Lin, Qi Zeng, Junpeng Long, Jiao Yao, Fan Yi, Lei Meng, Qidi Ai, Naihong Chen
Summary: This review focuses on the therapeutic potential of Ginsenoside Rg1 for improving neurological diseases. It discusses the mechanisms of Rg1 in neurological diseases and proposes Rg1 as a new method for clinical treatment.
Review
Chemistry, Medicinal
Chang Shu, Shumei Han, Peng Xu, Ying Wang, Tingting Cheng, Cong Hu
Summary: Preeclampsia is associated with a significant decrease in estrogen levels, which can be normalized by exogenous estradiol administration. The decrease in estrogen levels may be attributed to changes in enzyme activities in the placental trophoblast cells. Activation of the estrogenic G-protein-coupled receptor 30 (GPR30) has protective effects on the placenta. Estrogens play a role in improving placental perfusion through various mechanisms.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Erkan Kilinc, Seyit Ankarali, Didem Ayhan, Handan Ankarali, Ibrahim Ethem Torun, Ayhan Cetinkaya
Summary: This study shows that long-term probiotic supplementation can reduce seizures induced by PTZ in rats, by affecting duration and onset time of the seizures, and mitigating levels of inflammation and oxidative stress.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Plant Sciences
Jiahan Su, Tingting He, Jing You, Jingjie Cao, Qianru Wang, Shousong Cao, Qibing Mei, Jing Zeng, Li Liu
Summary: This study aimed to investigate the therapeutic effect and underlying mechanism of Shenkang injection (SKI) against cisplatin-induced acute kidney injury (AKI). The results showed that SKI improved renal function, reduced inflammation and oxidative stress, and regulated signaling pathways related to inflammation, oxidative stress, and apoptosis. This study provides a scientific rationale for the clinical use of SKI in treating cisplatin-induced AKI.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sara T. Elazab, Nahla S. Elshater, Asmaa T. Y. Kishaway, Huda A. EI-Emam
Summary: The study found that cinnamon extract and probiotic have remarkable antioxidant, anti-inflammatory, and antiapoptotic properties against renal injury caused by excessive copper in broiler chickens.
Article
Cell Biology
Pavan Thapak, Pragyanshu Khare, Mahendra Bishnoi, Shyam Sunder Sharma
Summary: The study suggests that 2-APB has a neuroprotective effect in A beta-induced cognitive impairment. It decreases the expression of TRPM2, improves cognitive function, and regulates calcium and memory-related proteins.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Pavan Thapak, Mahendra Bishnoi, Shyam Sunder Sharma
Summary: Research has shown that the expression of TRPV2 channels is upregulated in Alzheimer's disease models, and is associated with cognitive impairment. Treatment with tranilast can improve cognitive parameters by reducing TRPV2 expression and AChE activity.
NEUROMOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Vijay Kumar, Vibhu Kumar, Neha Mahajan, Jasleen Kaur, Kirti Devi, Ravinder Naik Dharavath, Ravindra Pal Singh, Kanthi Kiran Kondepudi, Mahendra Bishnoi
Summary: The study found that taking capsaicin and mucin had similar anti-obesity effects, indicating that mucin modulation might play a crucial role in the anti-obesity effects of capsaicin. 16S rDNA sequencing and in vitro Ca2+ measurement experiments suggested that bacteria, in addition to capsaicin, are involved in TRPV1 modulation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Nihar Ranjan Das, Bhupesh Vaidya, Pragyanshu Khare, Mahendra Bishnoi, Shyam Sunder Sharma
Summary: The combination therapy of PPAR gamma agonist and PGC-1 alpha activator alleviated cognitive deficits, oxidative stress, and inflammation in the MPTP-induced PD model, suggesting a potential therapeutic strategy for neurological diseases like PD.
CURRENT NEUROVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Neha Mahajan, Pragyanshu Khare, Kanthi Kiran Kondepudi, Mahendra Bishnoi
Summary: The TRPA1 channel is a calcium permeable, non-selective cation channel expressed in sensory neurons and non-neuronal cells, involved in pain, inflammation, and various physiological functions. It is modulated by pungent compounds in spices and herbs, and its agonism has potential in body weight control, hormone secretion, insulin release, and thermogenesis, making it a possible target for obesity prevention and therapeutic intervention. Recent research has focused on dietary and non-dietary modulation of TRPA1 for its role in combating obesity and related conditions such as insulin resistance in type 2 diabetes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Food Science & Technology
Ravindra Pal Singh, Jayashree Niharika, Kanthi Kiran Kondepudi, Mahendra Bishnoi, Jagan Mohan Rao Tingirikari
Summary: Human milk oligosaccharides (HMOs) are complex sugars present in breast milk, playing crucial roles in infant development by providing energy for gut microbes and directly modulating gut immune responses. Additionally, HMOs protect infants from infectious diseases by interacting with intestinal cells and inhibiting the binding of pathogenic bacteria and viruses.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Jasleen Kaur, Vijay Kumar, Vibhu Kumar, Sadiah Shafi, Pragyanshu Khare, Neha Mahajan, Sanjay K. Bhadada, Kanthi Kiran Kondepudi, Rupam Kumar Bhunia, Anurag Kuhad, Mahendra Bishnoi
Summary: The study demonstrated that supplementation of a tri-agonist consisting of capsaicin, menthol, and cinnamaldehyde at sub-effective doses prevented weight gain, improved glucose homeostasis, and inhibited adipose tissue hypertrophy induced by a high-fat diet in mice. This approach may be used to develop functional foods for therapeutic and preventive strategies against complications associated with high-fat diet consumption.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Nutrition & Dietetics
Dharmisthaben Patel, Amar Sakure, Dikshita Lodha, Bethsheba Basaiawmoit, Ruchika Maurya, Sujit Das, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Subrota Hati
Summary: This study aimed to assess the bio-functional properties of camel milk, including its antioxidative and anti-inflammatory activities, through fermentation with Lactobacillus fermentum strain KGL4. The study also identified and characterized the bioactive peptides released during fermentation. The results showed that the fermented camel milk exhibited high antioxidant activity and the KGL4 strain produced novel antioxidative peptides.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Vibhu Kumar, Vijay Kumar, Kirti Devi, Ajay Kumar, Rehan Khan, Ravindra Pal Singh, Sivasubramanian Rajarammohan, Kanthi Kiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
Summary: The study investigated the effects of TRPA1/TRPV1 modulation on colonic mucus production and gut health. It found that modulation of TRPA1/TRPV1 resulted in damaged mucosal lining, increased gut permeability, and altered transcriptional profile of related genes. These results suggest caution should be exercised when considering TRPA1/TRPV1 modulation as a therapeutic option for pain caused by IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kirti Devi, Vibhu Kumar, Vijay Kumar, Neha Mahajan, Jasleen Kaur, Shikha Sharma, Ajay Kumar, Rehan Khan, Mahendra Bishnoi, Kanthi Kiran Kondepudi
Summary: Chemical-enzymatic processing of finger millet, kodo millet, and rice bran removes lipids and antinutrients, making them effective in preventing high fat diet-induced obesity and improving glucose homeostasis and gut health.
Review
Chemistry, Medicinal
Leander Corrie, Ankit Awasthi, Jaskiran Kaur, Sukriti Vishwas, Monica Gulati, Indu Pal Kaur, Gaurav Gupta, Nagavendra Kommineni, Kamal Dua, Sachin Kumar Singh
Summary: Polycystic Ovarian Syndrome (PCOS) is a group of symptoms that increase the risk of various diseases, including type 2 diabetes, cardiovascular disease, and cancer. Currently, there are no effective and safe methods to treat all the pathological symptoms of PCOS. The gut microbiota plays an important role in the incidence and progression of PCOS. Many dietary plants, prebiotics, and probiotics have been reported to improve PCOS symptoms. This comprehensive review focuses on the use of polyphenols, probiotics, and fecal microbiota therapy to modify the gut microbiota and treat PCOS.
Article
Chemistry, Medicinal
Vibhu Kumar, Vijay Kumar, Kanthi Kiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
Summary: The study aimed to investigate the effects of altered colonic mucosal health and high-fat diet in mice. It also examined whether this combination prevented the protective actions of dietary prebiotic, isomaltooligosaccharides. The study found that the combination of altered colonic mucosal health and high-fat diet exacerbated the damage to mucosal lining, intestinal permeability, tight junction protein expression, SCFA levels, and gut bacterial abundances. The findings suggest that colonic precondition is crucial in determining the impact of high-fat diet and the success of diet-associated interventions.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Arif Hassan Dar, Anas Ahmad, Ajay Kumar, Vijayendran Gowri, Chandrashekhar Jori, Shaifali Sartaliya, K. M. Neethu, Nemat Ali, Mahendra Bishnoi, Rehan Khan, Govindasamy Jayamurugan
Summary: This study focuses on the development of luminescent dyes based on TCBDs and their transformation into water-soluble nanoaggregates. These nanoaggregates exhibit high emissivity and have potential applications in bioimaging and photodynamic therapy, specifically targeting cancer cells and increasing cell death activity.
Article
Engineering, Biomedical
Neetika Sharma, Karan Vasisht, Jasmine Kaur, Simarjot Kaur Sandhu, Kaustav Dey, Bakr Ahmed Hameed, Rakesh Bajaj, Indu Pal Kaur, Maninder Karan
Summary: Drug-delivery systems using phytopharmaceuticals based on traditional knowledge provide an alternative and faster strategy for drug development. Nanophytopharmaceuticals offer opportunities to overcome challenges associated with herbal medicines, such as low solubility and bioavailability, poor target specificity, and short shelf life. By developing solid lipid nanoparticles (SLNs) using berberis extracts as an effective drug-delivery system, the poor biopharmaceutical properties of the traditional remedy were improved, resulting in faster and complete healing of wounds.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Polymer Science
Bhumika Gupta, Garima Sharma, Pratibha Sharma, Simarjot Kaur Sandhu, Indu Pal Kaur
Summary: In this study, a self-gelling solid lipid nanoparticle (SLN) dressing incorporating the lipophilic wound-healing agent simvastatin was developed. The SLN-hydrogel exhibited good mechanical properties, slow release, and improved wound healing in rat models. The novel hydrogel dressing shows promise for wound care applications.
