Chimeric Antigen Receptor T-Cells (CAR T-Cells) for Cancer Immunotherapy – Moving Target for Industry?

Cytokine Release Syndrome Grade as a Predictive Marker for Infections in Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Treated With Chimeric Antigen Receptor T Cells

(2018) Jae H Park et al.   CLINICAL INFECTIOUS DISEASES

A Review of CRISPR-Based Genome Editing: Survival, Evolution and Challenges

(2018) Hafiz Ishfaq Ahmad et al.   CURRENT ISSUES IN MOLECULAR BIOLOGY

Sequential loss of tumor surface antigens following chimeric antigen receptor T-cell therapies in diffuse large B-cell lymphoma

(2018) Haneen Shalabi et al.   HAEMATOLOGICA

Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

(2018) Jian Li et al.   Journal of Hematology & Oncology

Sequential loss of tumor surface antigens following chimeric antigen receptor T-cell therapies in diffuse large B-cell lymphoma

(2018) Haneen Shalabi et al.   HAEMATOLOGICA

Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

(2018) Jean-Marc Hoffmann et al.   Frontiers in Immunology

Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy

(2018) Soumaya Kouidhi et al.   Frontiers in Immunology

CD20-CD19 Bispecific CAR T Cells for the Treatment of B-Cell Malignancies

(2017) Alexandra Martyniszyn et al.   HUMAN GENE THERAPY

Tumor-targeting domains for chimeric antigen receptor T cells

(2017) Ksenia Bezverbnaya et al.   Immunotherapy

JCAR015 in ALL: A Root-Cause Investigation

(2017)   Cancer Discovery

CAR T-Cell Therapy: Progress and Prospects

(2017) Olivia Wilkins et al.   Human Gene Therapy Methods

Global Manufacturing of CAR T Cell Therapy

(2017) Bruce L. Levine et al.   Molecular Therapy-Methods & Clinical Development

Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity

(2017) Spencer Park et al.   Scientific Reports

Toxicities of chimeric antigen receptor T cells: recognition and management

(2016) Jennifer N. Brudno et al.   BLOOD

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

(2016) Jiangtao Ren et al.   CLINICAL CANCER RESEARCH

Chimeric Antigen Receptor T cells for B Cell Neoplasms: Choose the Right CAR for You

(2016) Marco Ruella et al.   Current Hematologic Malignancy Reports

TRUCKs: the fourth generation of CARs

(2015) Markus Chmielewski et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Chimeric Antigen Receptor– and TCR-Modified T Cells Enter Main Street and Wall Street

(2015) David M. Barrett et al.   JOURNAL OF IMMUNOLOGY

Overcoming Antigen Escape with CAR T-cell Therapy

(2015) H. J. Jackson et al.   Cancer Discovery

A BCMA-specific CAR T cell produced with clinically scalable lentiviral and T cell manufacturing processes has potent anti-multiple myeloma activity

(2015) Tracy E Garrett et al.   Journal for ImmunoTherapy of Cancer

Clinical Immunotherapy of B-Cell Malignancy Using CD19-Targeted CAR T-Cells

(2014) John Maher   CURRENT GENE THERAPY

The Committee for Advanced Therapies' of the European Medicines Agency Reflection Paper on Management of Clinical Risks Deriving from Insertional Mutagenesis

(2013) Alessandro Aiuti et al.   Human Gene Therapy Clinical Development

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine