Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods

Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung

(2016) Otmar Schmid et al.   JOURNAL OF AEROSOL SCIENCE

Simplein vitromodels can predict pulmonary toxicity of silver nanoparticles

(2016) Hedwig M. Braakhuis et al.   Nanotoxicology

Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

(2016) Thomas Loret et al.   Particle and Fibre Toxicology

An in vitro alveolar macrophage assay for predicting the short-term inhalation toxicity of nanomaterials

(2016) Martin Wiemann et al.   JOURNAL OF NANOBIOTECHNOLOGY

Toxicity of copper oxide nanoparticles in lung epithelial cells exposed at the air–liquid interface compared with in vivo assessment

(2015) Xuefang Jing et al.   TOXICOLOGY IN VITRO

Pulmonary toxicity of nanomaterials: a critical comparison of published in vitro assays and in vivo inhalation or instillation studies

(2014) Robert Landsiedel et al.   Nanomedicine

Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

(2014) Justin G Teeguarden et al.   Particle and Fibre Toxicology

Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation

(2014) Brittany L Baisch et al.   Particle and Fibre Toxicology

An integrated approach for the in vitro dosimetry of engineered nanomaterials

(2014) Joel M Cohen et al.   Particle and Fibre Toxicology

Estimating the effective density of engineered nanomaterials for in vitro dosimetry

(2014) Glen DeLoid et al.   Nature Communications

Comparative lung toxicity of engineered nanomaterials utilizing in vitro, ex vivo and in vivo approaches

(2014) Yong Ho Kim et al.   JOURNAL OF NANOBIOTECHNOLOGY

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

Intracellular oxidative stress caused by nanoparticles: What do we measure with the dichlorofluorescein assay?

(2013) Peter H. Hoet et al.   Nano Today

Concern-driven integrated approaches to nanomaterial testing and assessment – report of the NanoSafety Cluster Working Group 10

(2013) Agnes G. Oomen et al.   Nanotoxicology

Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats

(2013) Ilse Gosens et al.   Nanotoxicology

The Biologically Effective Dose in Inhalation Nanotoxicology

(2012) Ken Donaldson et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanoparticles: a review of particle toxicology following inhalation exposure

(2012) Shahnaz Bakand et al.   INHALATION TOXICOLOGY

Industrial production quantities and uses of ten engineered nanomaterials in Europe and the world

(2012) Fabiano Piccinno et al.   JOURNAL OF NANOPARTICLE RESEARCH

Screening of different metal oxide nanoparticles reveals selective toxicity and inflammatory potential of silica nanoparticles in lung epithelial cells and macrophages

(2012) A. Panas et al.   Nanotoxicology

Anin vivoandin vitrotoxicological characterisation of realistic nanoscale CeO2inhalation exposures

(2012) Philip Demokritou et al.   Nanotoxicology

Validation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterials

(2012) Jong Sung Kim et al.   TOXICOLOGY IN VITRO

Cytokine production by co-cultures exposed to monodisperse amorphous silica nanoparticles: The role of size and surface area

(2012) Dorota Napierska et al.   TOXICOLOGY LETTERS

In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung—A dialog between aerosol science and biology

(2011) Hanns-Rudolf Paur et al.   JOURNAL OF AEROSOL SCIENCE

Aerosolized ZnO Nanoparticles Induce Toxicity in Alveolar Type II Epithelial Cells at the Air-Liquid Interface

(2011) Yumei Xie et al.   TOXICOLOGICAL SCIENCES

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Physico-chemical features of engineered nanoparticles relevant to their toxicity

(2010) Bice Fubini et al.   Nanotoxicology

Deposition and biokinetics of inhaled nanoparticles

(2010) Marianne Geiser et al.   Particle and Fibre Toxicology

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

In vitromodels of the human epithelial airway barrier to study the toxic potential of particulate matter

(2008) Barbara Rothen-Rutishauser et al.   Expert Opinion on Drug Metabolism & Toxicology