Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Article
Chemistry, Medicinal
Okhil K. Nag, Jawad Naciri, Kwahun Lee, Eunkeu Oh, Bethany Almeida, James B. Delehanty
Summary: In this study, a liquid crystal nanoparticle (LCNP) conjugate system was developed to enhance the cellular uptake and scavenging activity against reactive oxygen species (ROS) by combining the antioxidant TEMPO with the LCNP. The results showed that the TEMPO-conjugated LCNP effectively reduced ROS activity and lipid peroxidation in live cells, suggesting its potential in protecting cells from oxidative stress.
Article
Biology
Neville S. Ng, Lezanne Ooi
Summary: DCF probes are commonly used for detecting ROS in cell-based assays, but face challenges in intracellular microscopic analysis. Plate spectroscopy, combined with the SRB assay, provides a simple and effective method for stable measurement of cellular protein levels. This approach can enhance research in fields investigating cell differentiation, stress, and toxicity.
Review
Biochemistry & Molecular Biology
Eri Mukai, Shimpei Fujimoto, Nobuya Inagaki
Summary: The dysfunction of pancreatic beta-cells is crucial in the development of type 2 diabetes mellitus, characterized by impaired glucose stimulation and reduced ATP production. High glucose metabolism leads to the generation of reactive oxygen species in mitochondria, which affects beta-cells due to low expression of antioxidant enzymes. Activating the antioxidant defense factor Nrf2 may improve beta-cell dysfunction caused by ROS.
Review
Chemistry, Multidisciplinary
Zhao Jinyuan, Zhang Qian, Wang Jian, Zhang Qi, Li Heng, Du Yaping
Summary: This paper briefly reviews the research progress on scavenging materials for ROS and proposes a three-level pyramidic structure for the design of related materials. The design of nano-hybrid free radical scavenger not only solves the toxicity problem, but also provides additional functions.
ACTA CHIMICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Arina G. Kicheeva, Ekaterina S. Sushko, Lyubov S. Bondarenko, Kamila A. Kydralieva, Denis A. Pankratov, Nataliya S. Tropskaya, Artur A. Dzeranov, Gulzhian I. Dzhardimalieva, Mauro Zarrelli, Nadezhda S. Kudryasheva
Summary: The current study investigates the role of reactive oxygen species (ROS) in the bioeffects of different types of magnetite nanoparticles (MNPs) - bare (Fe3O4), humic acids (Fe3O4-Ha), and 3-aminopropyltriethoxysilane (Fe3O4-APTES) modified MNPs. The study found that Fe3O4-HA MNPs had the lowest amount of Fe2+ ions, while Fe3O4-APTES MNPs had the highest amount of Fe2+ ions. Bioluminescent cellular and enzymatic assays were used to monitor the toxicity and antioxidant activity of the MNPs. The results showed that the modified MNPs had toxic effects at higher concentrations (>10(-2) g/L) and stimulated ROS production by bacteria in a wide concentration range (10(-15)-1 g/L).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Xiangyu Wang, Hanjiang Zhao, Zhenchuan Liu, Yitong Wang, Dan Lin, Long Chen, Jiewen Dai, Kaili Lin, Steve G. Shen
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Debarshi Roy, Brenita Jenkins, Aqeeb Ali, Jacob R. Herschmann, Michele Harris, Matibur Zamadar, Laken Simington, Odutayo Odunuga, Prakash Adhikari, Prabhakar Pradhan, Sanjay Sarkar, Mahesh Pattabiram, Bidisha Sengupta
Summary: Ovarian cancer is a deadly gynecological cancer that often goes undetected until the advanced stage. A new study on photodynamic therapy has found that a drug combination can effectively inhibit the growth and induce cell death in drug-resistant and sensitive ovarian cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Medical Ethics
Shila Abdi, Benoit Nemery, Kris Dierickx
Summary: This study conducted a content analysis of misconduct reports from Denmark, the Netherlands, and Belgium to investigate how (alleged) cases of research misconduct are handled. The findings suggest that investigating committees assess the objective evidence, subjective intent, and case-specific circumstances when considering a case of misconduct. It was also revealed that the percentage of established misconduct varied across the countries.
ACCOUNTABILITY IN RESEARCH-ETHICS INTEGRITY AND POLICY
(2023)
Article
Environmental Sciences
Katrien De Troeyer, Jeroen De Man, Eline Vandebroek, Jeroen A. Vanoirbeek, Peter H. M. Hoet, Benoit Nemery, Christophe Vanroelen, Lidia Casas, Steven Ronsmans
Summary: This study investigated the associations between the use of different types of products and ocular/respiratory outcomes among domestic cleaners. The researchers found that cleaning products have adverse respiratory effects on domestic cleaners. Empowering cleaners to choose their own products can reduce the burden of work-related symptoms.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Lidia Casas, Bianca Cox, Benoit Nemery, Patrick Deboosere, Tim S. Nawrot
Summary: Temperature has an effect on the risk of suicide deaths, with higher temperatures increasing the risk within a week. However, there is no significant association between cold temperatures and suicide deaths.
ENVIRONMENTAL RESEARCH
(2022)
Review
Cell Biology
Nirosha Ganesan, Steven Ronsmans, Peter Hoet
Summary: The ability to monitor lymphocyte responses is crucial for understanding the immune response in humans. The current method, using [H-3] thymidine incorporation, has limitations in accurately measuring cell proliferation. There are several alternative techniques, most notably flow cytometry, that have shown promising results in measuring lymphocyte proliferation. This review evaluates these alternatives and their compatibility with the [H-3] thymidine method to identify the best replacement.
Review
Environmental Sciences
Aala Azari, Jeroen A. J. Vanoirbeek, Frank Van Belleghem, Brent Vleeschouwers, Peter H. M. Hoet, Manosij Ghosh
Summary: The pervasive pollution of microplastics and nano plastics (M/NPs) in indoor and outdoor atmospheres poses difficulties for comparing their prevalence due to various methodologies and non-standardization. This review extracts data from PubMed and Embase databases to analyze sampling strategies, identification methods, and reporting data for quantifying M/NPs. It primarily focuses on different methods for collecting atmospheric M/NPs and the analytical tools used for identification. The review identifies challenges and recommends further method development to support standardized and comparable future research.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Environmental Sciences
Vivi Schlunssen, Daniele Mandrioli, Frank Pega, Natalie C. Momen, Balazs Adam, Weihong Chen, Robert A. Cohen, Lode Godderis, Thomas Goen, Kishor Hadkhale, Watinee Kunpuek, Jianlin Lou, Stefan Mandic-Rajcevic, Federica Masci, Ben Nemery, Madalina Popa, Natthadanai Rajatanavin, Daria Sgargi, Somkiat Siriruttanapruk, Xin Sun, Repeepong Suphanchaimat, Panithee Thammawijaya, Yuka Ujita, Stevie van der Mierden, Katya Vangelova, Meng Ye, Muzimkhulu Zungu, Paul T. J. Scheepers
Summary: The WHO and ILO are developing joint estimates of the work-related burden of disease and injury. This study presents a systematic review and meta-analysis of occupational exposure to silica, asbestos, and coal dust. The findings will contribute to the development of the WHO/ILO Joint Estimates.
ENVIRONMENT INTERNATIONAL
(2023)
Letter
Environmental Sciences
Vivi Schlunssen, Balazs Adam, Natalie C. Momen, Ben Nemery, Frank Pega
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Manosij Ghosh, Katrijn Broothaerts, Steven Ronsmans, Ingrid Barcena Roig, Jef Scheepers, Mustafa Dikmen, Emily Rose Ciscato, Carolina Blanch, Michelle Plusquin, Unni C. Nygaard, Camilla Sandal Sejbaek, Karin S. Hougaard, Peter HM. Hoet
Summary: The article titled "Translation: Data Management Challenges and Solutions in the EXIMIOUS Project" discusses the difficulties faced by researchers in collecting and analyzing large volumes of data within collaborative projects. However, with the guidance and support from partner institutes, the researchers have been able to overcome these challenges and establish a data management framework that ensures data integrity, accessibility, and compliance with ethical and legal regulations.
ENVIRONMENTAL RESEARCH
(2023)
Review
Medicine, Legal
Jia-You Gong, Manosij Ghosh, Peter HM. Hoet
Summary: Electronic cigarette use is associated with metal exposure and adverse health effects such as cytotoxicity, oxidative stress, genotoxicity, and pro-inflammatory responses. Epidemiological studies indicate elevated metal burden in e-cigarette users, but more detailed data and information are needed to uncover the metal-related hazards of e-cigarettes.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Paul Musa Obadia, Joseph Pyana Kitenge, Tresor Carsi Kuhangana, Georges Kalenga Ilunga, Jaak Billen, Tony Kayembe-Kitenge, Vincent Haufroid, Abdon Mukalay Wa Mukalay, Laurence Ris, Celestin Banza Lubaba Nkulu, Benoit Nemery, Paul Enzlin
Summary: This study aimed to investigate factors associated with erectile dysfunction in metal miners in the Democratic Republic of the Congo. The results showed that miners had lower scores in sexual function and marital relation quality, as well as lower levels of free testosterone. Factors such as mining-related job, work seniority, alcohol consumption, and aphrodisiac use were associated with moderate erectile dysfunction. Marital relationship partially mediated the relation between work seniority and erectile dysfunction.
Article
Multidisciplinary Sciences
Nirosha Ganesan, Steven Ronsmans, Peter Hoet
Summary: The detection of antigen specific lymphocyte responses plays a vital role in diagnosing various diseases. This study evaluated the suitability of the Be-specific LPT and CFSE assay in detecting beryllium sensitivity in sarcoidosis patients with suspected beryllium exposure. The results showed that both LPT and CFSE assay are suitable for detecting beryllium sensitivity in sarcoidosis patients, but CFSE assay has an advantage in identifying the relevant proliferating lymphocyte populations.
Article
Biochemistry & Molecular Biology
Tony Kayembe-Kitenge, Celestin Banza Lubaba Nkulu, Sebastien Mbuyi Musanzayi, Toni Lubala Kasole, Leon Kabamba Ngombe, Paul Musa Obadia, Daan Van Brusselen, Daniel Kyanika Wa Mukoma, Taty Muta Musambo, Augustin Mutombo Mulangu, Patient Nkulu Banza, P. D. M. C. Katoto, Erik Smolders, Benoit Nemery, Tim Nawrot
Summary: This first study on maternal and neonatal cobalt concentrations in the African Copperbelt provides strong evidence of a high transfer of cobalt from mother to fetus.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Meeting Abstract
Respiratory System
S. Ronsmans, P. Goeminne, N. Jerjir, V. Nowe, E. Vandebroek, S. Keirsbilck, B. Weynand, P. H. M. Hoet, J. A. J. Vanoirbeek, W. A. Wuyts, J. Yserbyt, B. Nemery
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Nirosha Ganesan, Steven Ronsmans, Peter Hoet
Summary: Silicosis is a disease caused by inhaling silica particles, which can lead to inflammation and the release of cytokines. This study found that lymphocytes from silicosis patients had a stronger response to silica particles compared to controls, and there were changes in the levels of immune cell subsets and cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Steven Ronsmans, Karin Sorig Hougaard, Tim S. Nawrot, Michelle Plusquin, Francois Huaux, Maria Jesus Cruz, Horatiu Moldovan, Steven Verpaele, Murali Jayapala, Michael Tunney, Stephanie Humblet-Baron, Hubert Dirven, Unni Cecilie Nygaard, Birgitte Lindeman, Nur Duale, Adrian Liston, Esben Meulengracht Flachs, Kenneth Kastaniegaard, Matthias Ketzel, Julia Goetz, Jeroen Vanoirbeek, Manosij Ghosh, Peter H. M. Hoet
Summary: This article introduces the EXIMIOUS consortium, a research project that aims to study the relationship between immune-mediated, noncommunicable diseases and environmental factors. By integrating large datasets and applying innovative bioinformatics tools, researchers will explore the immune system's response to exposome and identify early predictors of diseases.
ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.
