Article
Environmental Sciences
Maria-Sofia Vidali, Stefanos Dailianis, Dimitris Vlastos, Panagiotis Georgiadis
Summary: The study found that under conditions of exposure to PCB, there was a significant dose-dependent hypomethylation in the human lymphocyte methylome, even at low concentrations. However, all compounds tested did not show significant genotoxic effects during the testing period.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Kristina Cabanova, Oldrich Motyka, Hana Bielnikova, Lenka Cabalova, Petr Handlos, Dominika Zabiegaj, Karol Zelenik, Jana Dvorackova, Pavel Kominek, Silvie Heviankova, Miroslav Havlicek, Jana Kukutschova
Summary: Solid metal-based particles may play a role in the pathogenesis of chronic hypertrophic rhinitis, as indicated by Raman microspectroscopy analysis revealing the presence of various compounds in the nasal mucosa of affected patients. This direct identification of compounds can provide insight into the health of individuals and potential causes of mucosal diseases.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Silvia Aidee Solorio-Rodriguez, Andrew Williams, Sarah Sos Poulsen, Kristina Bram Knudsen, Keld Alstrup Jensen, Per Axel Clausen, Pernille Hogh Danielsen, Hakan Wallin, Ulla Vogel, Sabina Halappanavar
Summary: This study aimed to determine the influence of single or multi-walled structures and surface functionalization on pulmonary toxicity of carbon nanotubes (CNTs) and to identify the underlying mechanisms. Mice were exposed to different doses of SWCNTs or MWCNTs, and inflammation and DNA damage were assessed. Transcriptomics analysis showed similar responses across all CNTs, with inflammation, cellular stress, metabolism, and DNA damage responses being affected. One pristine SWCNT was found to be the most potent and potentially fibrogenic, warranting further toxicity testing.
Article
Nanoscience & Nanotechnology
Emilio Di Ianni, Peter Moller, Tanya Cholakova, Henrik Wolff, Nicklas Raun Jacobsen, Ulla Vogel
Summary: Carbon black nanoparticles with large surface area/volume ratio may cause oxidative stress and inflammation, and the study found that surface area is correlated with inflammation while mass is correlated with genotoxicity.
Article
Environmental Sciences
Luisa Albarano, Maria Toscanesi, Marco Trifuoggi, Marco Guida, Giusy Lofrano, Giovanni Libralato
Summary: This study investigated the use of activated carbon (AC) and nano-zero-valent iron (nZVI) as methods for the remediation of marine contaminated sediment and water. The results suggested that AC is safer than nZVI, but further research and optimization are needed for the application of nZVI.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Chemical
Theodoro da Rosa Salles, Carlos Schnorr, Franciele da Silva Bruckmann, Enzo Cassol Vicensi, Altevir Rossato Viana, Andre Pasaglia Schuch, Wagner de Jesus da Silva Garcia, Luis F. O. Silva, Artur Harres de Oliveira, Sergio Roberto Mortari, Cristiano Rodrigo Bohn Rhoden
Summary: This study investigates the adsorption of furosemide using magnetic carbon nanotubes (CNT center dot Fe3O4) with different amounts of magnetite. The adsorbents were synthesized using chemical vapor deposition (CVD) and co-precipitation methods. The experimental results showed that the CNT center dot Fe3O4 1:10 had the best performance, with a removal percentage of 82.39% and a maximum adsorption capacity of 83.5 mg g-1 at pH 2.0.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carolina D. Alberca, Ligia A. Papale, Andy Madrid, Reid S. Alisch
Summary: Whole genome methylation profiling reveals the systemic contributions of DNA methylation to ASD, with shared differentially methylated regions (DMRs) between brain and blood tissues. These regions are linked to risk genes for neurodevelopmental disorders and intellectual disabilities, suggesting the influence of DNA methylation on gene expression regulation in ASD pathogenesis.
HUMAN MOLECULAR GENETICS
(2023)
Editorial Material
Genetics & Heredity
Moshe Szyf
Summary: Professor Moshe Szyf is an authority in the field of social epigenetics and has made important research contributions, including identifying DNA methylation as a therapeutic target and studying the impact of social environment on DNA methylation. He is also the founder and leader of multiple institutions and projects.
Article
Evolutionary Biology
Aline M. Muyle, Danelle K. Seymour, Yuanda Lv, Bruno Huettel, Brandon S. Gaut
Summary: Gene body methylation in plants is an epigenetic mark that may be shaped by adaptation. This review discusses the establishment and maintenance of gene body methylation, as well as its potential roles in stabilizing and upregulating gene expression, inhibiting aberrant transcription, preventing intron retention, and protecting against transposable element insertions. While evidence supports a correlation between gene body methylation and gene expression patterns, it remains unclear if this relationship is causal.
GENOME BIOLOGY AND EVOLUTION
(2022)
Review
Chemistry, Multidisciplinary
Kangying Wu, Qixing Zhou, Shaohu Ouyang
Summary: Graphene family nanomaterials have diverse applications and potential genotoxic effects on DNA, with mechanisms classified into direct and indirect genotoxicity. Factors such as physicochemical properties, exposure dose, and time influence the genotoxicity of GFNs, requiring further research on testing methods and response mechanisms.
Article
Chemistry, Physical
Giovanni Scala, Mathilde N. Delaval, Sourav P. Mukherjee, Antonio Federico, Timur O. Khaliullin, Naveena Yanamala, Liliya M. Fatkhutdinova, Elena R. Kisin, Dario Greco, Bengt Fadeel, Anna A. Shvedova
Summary: The study revealed that MWCNTs exert epigenetic effects in the lungs, potentially driving subsequent gene expression changes. Muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways.
Article
Plant Sciences
Soudeh Ghorbani, Alireza Iranbakhsh, Mostafa Ebadi, Zahra Oraghi Ardebili
Summary: In recent years, the use of nano-scaled substances in plant cell, tissue, and organ culture has seen significant advancements. This study explored the effects of carboxylic acid-functionalized multi-walled carbon nanotubes (COOH-MWCNTs) on the growth and development of Salvia nemorosa. It was found that COOH-MWCNTs positively influenced plant growth, organ development, and biomass accumulation. Additionally, the application of COOH-MWCNTs led to changes in DNA methylation, increased concentrations of photosynthetic pigments, and enhanced protein content and enzyme activity in the plants.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Biotechnology & Applied Microbiology
Adam Nunn, Christian Otto, Mario Fasold, Peter F. Stadler, David Langenberger
Summary: This study presents a computational pre-processing approach to enable downstream analysis on a per-strand basis using conventional variant calling software. The method improves precision and sensitivity compared to specialized tools, and is applicable to both human and model plant variants.
Article
Biochemistry & Molecular Biology
Durgesh Mourya, Kavita Dubey, Shambhavi Jha, Renuka Maurya, Alok Kumar Pandey
Summary: This study aimed to determine the genotoxic and mutagenic effects of zirconia nanoparticles in V-79 lung cells. The results showed that zirconia nanoparticles were internalized in cells and generated ROS. The alkaline comet assay revealed significant DNA strand breaks, while the neutral comet assay showed significant damage. Chromosomal aberration induced by zirconia nanoparticles mainly resulted in gaps, fragments, and breaks. In the HPRT mutation assay, there was a dose-dependent increase in mutant frequency. It is evident that zirconia nanoparticles cause dose-dependent cytotoxicity and genotoxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Plant Sciences
Dipnarayan Saha, Arun Kumar Shaw, Subhojit Datta, Jiban Mitra, Gouranga Kar
Summary: This study investigated the DNA methylation patterns in flax under heat stress and hypomethylation treatment. The results showed significant differentially methylated regions (DMRs), particularly hypomethylated DMRs, in the CHH nucleotide sequence context. These DMRs were found in intergenic regions and near genes relevant to heat stress response and epigenetic processes, suggesting their possible role in promoter methylation and gene silencing.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Medicine, General & Internal
N. Fraeyman, D. De Bacquer, T. Fiers, L. Godderis, R. Verhaeghe, K. Eeckloo, P. Gemmel, L. Viaene, E. Mortier
Summary: This study aimed to analyze the relationship between BMI and ergonomic accidents. The study found that factors such as gender, age, and functional status of employees influenced the incidence of ergonomic accidents, but BMI was not independently associated. Furthermore, the type and severity of accidents were also unrelated to BMI.
ACTA CLINICA BELGICA
(2023)
Editorial Material
Public, Environmental & Occupational Health
Vivi Schlunssen, Jean Baptist du Prel, Martie van Tongeren, Lode Godderis, Michelle C. Turner, Damien McElvenny
Summary: Harmonized tools and approaches for data collection can help detect similarities and differences in COVID-19 across countries and support the development of effective preventive strategies. The open source occupational questionnaires on COVID-19 provide comprehensive coverage of key aspects related to the pandemic. However, the general questionnaire has a limited number of questions for each domain.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Correction
Oncology
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca Maria Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmen, Diether Lambrechts, Pascal Merchiers, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
Article
Environmental Sciences
Imane Berni, Aziza Menouni, Matteo Creta, Ibrahim El Ghazi, Radu-Corneliu Duca, Lode Godderis, Samir El Jaafari
Summary: This study aimed to evaluate the levels of glyphosate and its metabolite AMPA in Moroccan children, identify predictors, and conduct a risk assessment. The study found that glyphosate and AMPA were detected in the urine of 73% and 75% of children, respectively, with higher concentrations in younger children and those living near pesticide spraying fields. Factors such as drinking water source and household income were also associated with AMPA concentration. The health risk assessment showed low risk for the target population.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castano, Adrian Covaci, Radu Corneliu Duca, Sarah Faure, Karen S. Galea, Sean Hays, Nancy B. Hopf, Yuki Ito, Maryam Zare Jeddi, Marike Kolossa-Gehring, Eva Kumar, Judy S. LaKind, Marta Esteban Lopez, Henriqueta Louro, Kristin Macey, Konstantinos C. Makris, Lisa Melnyk, Aline Murawski, Josh Naiman, Julianne Nassif, Nolwenn Noisel, Devika Poddalgoda, Lesliam Quiros-Alcala, Ata Rafiee, Loic Rambaud, Maria Joao Silva, Jun Ueyama, Marc-Andre Verner, Maisarah Nasution Waras, Kate Werry
Summary: Human biomonitoring (HBM) data can be used to compare population exposures, but finding the relevant health-based biomonitoring guidance values can be time-consuming. To address this issue, an online repository called the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard has been created. This database provides a centralized location for researchers and decision makers to access and interpret HBM data.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Anesthesiology
Lore Dams, Elien Van der Gucht, Nele Devoogdt, Ann Smeets, Koen Bernar, Bart Morlion, Lode Godderis, Vincent Haenen, Tessa De Vrieze, Steffen Fieuws, Niamh Moloney, Paul Van Wilgen, Mira Meeus, An De Groef
Summary: Pain is a common and long-lasting side effect in women who have undergone surgical treatment for breast cancer. Pain neuroscience education (PNE) is an effective educational intervention that not only explains pain from a biomedical perspective but also considers psychological and social factors. In a randomized controlled trial, PNE showed similar results to providing a biomedical explanation for pain in terms of reducing pain-related disability and improving secondary outcomes.
Review
Medicine, General & Internal
Arne Wyns, Jolien Hendrix, Astrid Lahousse, Elke De Bruyne, Jo Nijs, Lode Godderis, Andrea Polli
Summary: Stress has negative impacts on physical and mental health, especially for patients with chronic pain who experience stress intolerance. This paper summarizes the role of the autonomic nervous system and hypothalamus-pituitary-adrenal axis in stress intolerance based on clinical and preclinical studies. The (epi)genetic mechanisms influencing these stress systems are also explored. Understanding the connection between stress, HPA axis, ANS, and chronic health conditions like chronic pain is crucial for improving public health and well-being.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Octavio Jimenez-Garza, Manosij Ghosh, Timothy M. Barrow, Lode Godderis
Summary: This review summarizes the findings of DNA methylation studies in blood cells of workers exposed to toxicants. The results suggest that DNA methylation changes are associated with disease development in occupational exposures, but the heterogeneity in genes studied and the lack of longitudinal studies limit their use as biomarkers in occupational settings.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Baptiste Lamarthee, Jasper Callemeyn, Yannick Van Herck, Asier Antoranz, Dany Anglicheau, Patrick Boada, Jan Ulrich Becker, Tim Debyser, Frederik De Smet, Katrien De Vusser, Maeva Eloudzeri, Amelie Franken, Wilfried Gwinner, Priyanka Koshy, Dirk Kuypers, Diether Lambrechts, Pierre Marquet, Virginie Mathias, Marion Rabant, Minnie M. Sarwal, Aleksandar Senev, Tara K. Sigdel, Ben Sprangers, Olivier Thaunat, Claire Tinel, Thomas Van Brussel, Amaryllis Van Craenenbroeck, Elisabet Van Loon, Thibaut Vaulet, Francesca Bosisio, Maarten Naesens
Summary: Although kidney allograft failure is classified as either T cell- or antibody-mediated, this distinction is not always clear in all patients, emphasizing the need for better characterization of allograft tissue. The authors used single-cell RNA sequencing and multiplex imaging to analyze the transcriptomes and spatial profiles of allograft tissue from patients with different degrees of rejection severity. The study identified specific cell types and gene expression signatures associated with rejection, highlighting the involvement of innate immune cells in allograft rejection and suggesting potential therapeutic targets to improve graft longevity.
NATURE COMMUNICATIONS
(2023)
Article
Respiratory System
Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Summary: The exposome approach can improve our understanding of multifactorial respiratory diseases by collaborating across disciplines, coordinating resources, and utilizing advanced methods to study combined exposures and longitudinal data.
Meeting Abstract
Oncology
Ian S. Miller, Valentina Thomas, Tom Venken, Ingrid Arijs, Ana Barat, Johannes Betge, Tianzuo Zhan, Timo Gaiser, Matthias P. Ebert, Jochen Prehn, Rut Klinger, Darran P. O'Connor, Brian Brian Moulton, Verena Murphy, Ray McDermott, Brian Bird, Gregory Leonard, Liam Grogan, Anne Horgan, Nadine Schulte, Markus Moehler, Nicole Prannikar, Judith Franz-Werner, Hans-Peter Feustel, Diether Lambrechts, Annette T. Byrne
Meeting Abstract
Oncology
Francesca Lodi, Sam Vanmassenhove, Elena Donders, Pierre Van Mol, Amelie Franken, Sarah Cappuyns, Ayse Bassez, Siel Olbrecht, Liselore Loverix, Michel Bila, Hanne Vos, Joanna Pozniak, Kevin Punie, Diether Lambrechts
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Meeting Abstract
Gastroenterology & Hepatology
Lukas Van Melkebeke, Jef Verbeek, Dora Bihary, Markus Boesch, Hannelie Korf, Diether Lambrechts, Schalk van der Merwe
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Bram Boeckx, Rogier Schepers, Thomas Van Brussel, Ingrid Arijs, Aurelie Mechels, Ayse Bassez, Francesca Lodi, Joris Jaekers, Halit Topal, Baki Topal, Orian Bricard, Junbin Qian, Eric Van Cutsem, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
JOURNAL OF HEPATOLOGY
(2023)