Single-Walled vs. Multi-Walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs

SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism

(2022) Yue Zhang et al.   Journal of Translational Medicine

Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study

(2022) Dina Mourad Saleh et al.   Particle and Fibre Toxicology

Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?

(2022) Suchi Smita Gupta et al.   Nanomaterials

Asthma and Post-Asthmatic Fibrosis: A Search for New Promising Molecular Markers of Transition from Acute Inflammation to Pulmonary Fibrosis

(2022) Innokenty Savin et al.   Biomedicines

Reactive oxygen species production, genotoxicity and telomere length in FE1-Muta™Mouse lung epithelial cells exposed to carbon nanotubes

(2021) Regitze Sølling Wils et al.   Nanotoxicology

Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models

(2021) David M Crizer et al.   TOXICOLOGICAL SCIENCES

Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung

(2021) Alessandro Marchioni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT

(2021) Emilio Di Ianni et al.   Particle and Fibre Toxicology

Potency ranking of per- and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids

(2021) A J F Reardon et al.   TOXICOLOGICAL SCIENCES

Transcriptomics Underlying Pulmonary Ozone Pathogenesis Regulated by Inflammatory Mediators in Mice

(2021) Hye-Youn Cho et al.   Antioxidants

Mechanical communication in fibrosis progression

(2021) Yi Long et al.   TRENDS IN CELL BIOLOGY

Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease

(2020) Niels Hadrup et al.   Small

21st Century Tools for Nanotoxicology: Transcriptomic Biomarker Panel and Precision‐Cut Lung Slice Organ Mimic System for the Assessment of Nanomaterial‐Induced Lung Fibrosis

(2020) Luna Rahman et al.   Small

Multi-walled carbon nanotubes (MWCNTs) transformed THP-1 macrophages into foam cells: Impact of pulmonary surfactant component dipalmitoylphosphatidylcholine

(2020) Jinru Lin et al.   JOURNAL OF HAZARDOUS MATERIALS

Alveolar lipids in pulmonary disease. A review

(2020) Christina W. Agudelo et al.   Lipids in Health and Disease

T Cells in Fibrosis and Fibrotic Diseases

(2020) Mengjuan Zhang et al.   Frontiers in Immunology

Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat

(2020) Dina Mourad Saleh et al.   Particle and Fibre Toxicology

Toxicity of Carbon Nanotubes: Molecular Mechanisms, Signaling Cascades, and Remedies in Biomedical Applications

(2020) Mansab Ali Saleemi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In vitro cytotoxicity study of superparamagnetic iron oxide and silica nanoparticles on pneumocyte organelles

(2020) A. Solorio-Rodríguez et al.   TOXICOLOGY IN VITRO

MWCNT ‐7 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats

(2019) Takamasa Numano et al.   CANCER SCIENCE

Comparison of the effects of multiwall carbon nanotubes on the epithelial cells and macrophages

(2019) Masanori Horie et al.   Nanotoxicology

Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation

(2019) Marit Ilves et al.   Particle and Fibre Toxicology

Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine

(2019) Matthew C. Madison et al.   JOURNAL OF CLINICAL INVESTIGATION

Circadian rhythms in skin and other elastic tissues

(2019) Michael J. Sherratt et al.   MATRIX BIOLOGY

Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice

(2019) Niels Hadrup et al.   Nanotoxicology

Oxidative damage of SP-D abolishes control of eosinophil extracellular DNA trap formation

(2018) Shida Yousefi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Type 2 Immune Mechanisms in Carbon Nanotube-Induced Lung Fibrosis

(2018) Jie Dong et al.   Frontiers in Immunology

BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation

(2018) Clemente J. Britto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes

(2017) Tyler A. Beach et al.   EXPERIMENTAL LUNG RESEARCH

A 104-week pulmonary toxicity assessment of long and short single-wall carbon nanotubes after a single intratracheal instillation in rats

(2017) Kazumasa Honda et al.   INHALATION TOXICOLOGY

Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles

(2017) Niels Hadrup et al.   MUTAGENESIS

Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis

(2017) Luna Rahman et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Harmful at non-cytotoxic concentrations: SiO2-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells

(2017) Veno Kononenko et al.   Nanotoxicology

Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework

(2017) Jake Nikota et al.   Particle and Fibre Toxicology

Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma

(2017) Mikaela A. Miller et al.   PLoS One

Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice

(2017) Sarah S. Poulsen et al.   PLoS One

Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone

(2016) Jonathan M. Ciencewicki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotubes

(2016) Jie Dong et al.   ARCHIVES OF TOXICOLOGY

A framework for the use of single-chemical transcriptomics data in predicting the hazards associated with complex mixtures of polycyclic aromatic hydrocarbons

(2016) Sarah Labib et al.   ARCHIVES OF TOXICOLOGY

Toxicogenomics analysis of mouse lung responses following exposure to titanium dioxide nanomaterials reveal their disease potential at high doses

(2016) Luna Rahman et al.   MUTAGENESIS

Multi-walled carbon nanotube physicochemical properties predict pulmonary inflammation and genotoxicity

(2016) Sarah S. Poulsen et al.   Nanotoxicology

Pulmonary and pleural inflammation after intratracheal instillation of short single-walled and multi-walled carbon nanotubes

(2016) Katsuhide Fujita et al.   TOXICOLOGY LETTERS

Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes

(2016) Jeffrey J. Sutherland et al.   PLoS Computational Biology

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

(2016) Sam Ansari et al.   Scientific Data

Integrated Analysis of Dysregulated ncRNA and mRNA Expression Profiles in Humans Exposed to Carbon Nanotubes

(2016) Anna A. Shvedova et al.   PLoS One

Circadian Clock–Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases

(2015) Isaac K. Sundar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist

(2015) Kathie-Anne Walters et al.   BMC GENOMICS

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

(2015) Sarah Labib et al.   Particle and Fibre Toxicology

Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats

(2015) Tatsuya Kasai et al.   Particle and Fibre Toxicology

Carbon black nanoparticles induce biphasic gene expression changes associated with inflammatory responses in the lungs of C57BL/6 mice following a single intratracheal instillation

(2015) Mainul Husain et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

(2015) Sarah S. Poulsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials

(2015) Andrew Williams et al.   Beilstein Journal of Nanotechnology

Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD

(2014) Gerrit John-Schuster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer

(2014) O. Delgado et al.   CLINICAL CANCER RESEARCH

Transcriptional profiling identifies physicochemical properties of nanomaterials that are determinants of the in vivo pulmonary response

(2014) Sabina Halappanavar et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

(2014) V. Pekovic-Vaughan et al.   GENES & DEVELOPMENT

Effect of Fiber Length on Carbon Nanotube-Induced Fibrogenesis

(2014) Amruta Manke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

(2014) Elina M Rydman et al.   Particle and Fibre Toxicology

Impact of Cigarette Smoke on the Human and Mouse Lungs: A Gene-Expression Comparison Study

(2014) Mathieu C. Morissette et al.   PLoS One

Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease

(2014) Anne T. Saber et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

Carbon Black Nanoparticle Intratracheal Instillation Does Not Alter Cardiac Gene Expression

(2013) Julie A. Bourdon et al.   Cardiovascular Toxicology

Mice exposed in situ to urban air pollution exhibit pulmonary alterations in gene expression in the lipid droplet synthesis pathways

(2013) Andrea Rowan-Carroll et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Role of Type II Pneumocyte Senescence in Radiation-Induced Lung Fibrosis

(2013) Deborah E. Citrin et al.   JNCI-Journal of the National Cancer Institute

Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay

(2013) P. Jackson et al.   MUTAGENESIS

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model

(2013) Tina M. Sager et al.   Nanotoxicology

Bleomycin Induces Molecular Changes Directly Relevant to Idiopathic Pulmonary Fibrosis: A Model for “Active” Disease

(2013) Ruoqi Peng et al.   PLoS One

Particle-Induced Pulmonary Acute Phase Response Correlates with Neutrophil Influx Linking Inhaled Particles and Cardiovascular Risk

(2013) Anne Thoustrup Saber et al.   PLoS One

Transcriptomic Analysis Reveals Novel Mechanistic Insight into Murine Biological Responses to Multi-Walled Carbon Nanotubes in Lungs and Cultured Lung Epithelial Cells

(2013) Sarah Søs Poulsen et al.   PLoS One

Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation

(2013) Mainul Husain et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

(2013) Christian Lacks Lino Cardenas et al.   PLoS Genetics

Overexpression of Tumor Necrosis Factor-α in the Lungs Alters Immune Response, Matrix Remodeling, and Repair and Maintenance Pathways

(2012) Errol M. Thomson et al.   AMERICAN JOURNAL OF PATHOLOGY

Strain-dependent Damage in Mouse Lung After Carbon Ion Irradiation

(2012) Takashi Moritake et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Multiwalled Carbon Nanotube-Induced Gene Signatures in the Mouse Lung: Potential Predictive Value for Human Lung Cancer Risk and Prognosis

(2012) Nancy L. Guo et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

In vivo genotoxicity study of single-wall carbon nanotubes using comet assay following intratracheal instillation in rats

(2012) Masato Naya et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Differential Transcriptomic Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non–Small Cell Lung Cancer

(2012) Arun R. Pandiri et al.   TOXICOLOGIC PATHOLOGY

Particulate Matter Induces Cardiac Arrhythmias via Dysregulation of Carotid Body Sensitivity and Cardiac Sodium Channels

(2011) Ting Wang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: A toxicogenomic study

(2011) Sabina Halappanavar et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Identification of Candidate Genes Downstream of TLR4 Signaling after Ozone Exposure in Mice: A Role for Heat-Shock Protein 70

(2011) Alison K. Bauer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

FIZZ2/RELM-  Induction and Role in Pulmonary Fibrosis

(2011) T. Liu et al.   JOURNAL OF IMMUNOLOGY

Exposure of pregnant mice to carbon black by intratracheal instillation: Toxicogenomic effects in dams and offspring

(2011) Petra Jackson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Novel Regulators of the Systemic Response to Lipopolysaccharide

(2010) Ivana V. Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Interleukin 6, but Not T Helper 2 Cytokines, Promotes Lung Carcinogenesis

(2010) C. E. Ochoa et al.   Cancer Prevention Research

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung Carcinoma

(2010) B. E. Schaffer et al.   CANCER RESEARCH

Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation

(2010) Gillian S. Backus et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Transcriptome of Nrf2−/− Mice Provides Evidence for Impaired Cell Cycle Progression in the Development of Cigarette Smoke–Induced Emphysematous Changes

(2010) Stephan Gebel et al.   TOXICOLOGICAL SCIENCES

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

(2009) Tirumalai Rangasamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

(2009) Nicklas Jacobsen et al.   Particle and Fibre Toxicology

Subchronic 13-Week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects Are Determined by Density of Agglomerate Structures, Not Fibrillar Structures

(2009) Jürgen Pauluhn   TOXICOLOGICAL SCIENCES

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Circadian Timing in the Lung; A Specific Role for Bronchiolar Epithelial Cells

(2008) J. E. Gibbs et al.   ENDOCRINOLOGY

Murine Lung Responses to Ambient Particulate Matter: Genomic Analysis and Influence on Airway Hyperresponsiveness

(2008) Ting Wang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Fibroproliferation in LPS-induced airway remodeling and bleomycin-induced fibrosis share common patterns of gene expression

(2008) David M. Brass et al.   IMMUNOGENETICS

Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung

(2008) J. J. Reece et al.   INFECTION AND IMMUNITY

Increased Transcription of Immune and Metabolic Pathways in Naïve and Allergic Mice Exposed to Diesel Exhaust

(2008) Tina Stevens et al.   TOXICOLOGICAL SCIENCES

Disease-Specific Gene Expression Profiling in Multiple Models of Lung Disease

(2007) Christina C. Lewis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY