Role and Possible Mechanisms of Sirt1 in Depression

Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer’s disease

(2018) Xinxin Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Influence of resveratrol pretreatment on thawed bovine embryo quality and mitochondrial DNA copy number

(2018) T. Hayashi et al.   THERIOGENOLOGY

Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration

(2017) Preeti Singh et al.   Parkinsons Disease

Down-Regulation ofSIRT1Gene Expression in Major Depressive Disorder

(2016) Xiong-Jian Luo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model

(2016) Hideto Ozawa et al.   ANNALS OF THORACIC SURGERY

Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior

(2016) Naoko Abe-Higuchi et al.   BIOLOGICAL PSYCHIATRY

Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats

(2016) B Raghunath Reddy et al.   JOURNAL OF BIOSCIENCES

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis

(2016) Liang Liu et al.   Oncotarget

Resveratrol abrogates lipopolysaccharide-induced depressive-like behavior, neuroinflammatory response, and CREB/BDNF signaling in mice

(2015) Li Ge et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

(2015) M Fava et al.   MOLECULAR PSYCHIATRY

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice

(2015) Syed Hamid Ali et al.   STEROIDS

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation

(2015) Paul J. Lucassen et al.   Cold Spring Harbor Perspectives in Biology

Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature and Reduced Glial Activation

(2015) Maheedhar Kodali et al.   Scientific Reports

SIRT1 Polymorphisms Associate with Seasonal Weight Variation, Depressive Disorders, and Diastolic Blood Pressure in the General Population

(2015) Leena Kovanen et al.   PLoS One

Antidepressant effects of resveratrol in an animal model of depression

(2014) Laura L. Hurley et al.   BEHAVIOURAL BRAIN RESEARCH

Neurogenesis as a New Target for the Development of Antidepressant Drugs

(2014) Jesus Pascual-Brazo et al.   CURRENT PHARMACEUTICAL DESIGN

Sirtuin Activity in Dentate Gyrus Contributes to Chronic Stress-Induced Behavior and Extracellular Signal-Regulated Protein Kinases 1 and 2 Cascade Changes in the Hippocampus

(2013) Chantelle L. Ferland et al.   BIOLOGICAL PSYCHIATRY

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in theSIRT1gene

(2013) Jeehae Han et al.   CELL CYCLE

The role of SIRT1 in ocular aging

(2013) Tatsuya Mimura et al.   EXPERIMENTAL EYE RESEARCH

Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons

(2013) C. Brochier et al.   JOURNAL OF NEUROSCIENCE

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

(2013) J. Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR

(2013) Luli Akinfiresoye et al.   PSYCHOPHARMACOLOGY

Neuroplasticity and the next wave of antidepressant strategies

(2013) Shawn Hayley et al.   Frontiers in Cellular Neuroscience

SIRT1 signaling as potential modulator of skeletal muscle diseases

(2012) Joanne Tonkin et al.   CURRENT OPINION IN PHARMACOLOGY

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Physiological and Pathophysiological Functions of SIRT1

(2012) M. Wojcik et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

(2011) Sergiy Libert et al.   CELL

SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance

(2011) Giorgio Ramadori et al.   Cell Metabolism

The Hippocampus, Neurotrophic Factors and Depression

(2011) Gabriele Masi et al.   CNS DRUGS

Is serotonergic function associated with the antidepressant effects of modified-electroconvulsive therapy?

(2011) Shinjiro Goto et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Sirtuins in Neurodegenerative Diseases: A Biological-Chemical Perspective

(2011) Aparna Raghavan et al.   Neurodegenerative Diseases

SIRT1 gene is associated with major depressive disorder in the Japanese population

(2010) Taro Kishi et al.   JOURNAL OF AFFECTIVE DISORDERS

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

(2010) Virginia Soria et al.   NEUROPSYCHOPHARMACOLOGY

Regulation of histone acetylation in the hippocampus of chronically stressed rats: a potential role of sirtuins

(2010) C.L. Ferland et al.   NEUROSCIENCE

Retinal Aging and Sirtuins

(2010) Yoko Ozawa et al.   OPHTHALMIC RESEARCH

Acteoside protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell injury

(2009) Hongquan Wang et al.   BRAIN RESEARCH

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction

(2009) D. E. Cohen et al.   GENES & DEVELOPMENT

Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins

(2009) William Renthal et al.   NEURON

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments

(2008) Darrick T. Balu et al.   BRAIN RESEARCH

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ups and downs of SIRT1

(2008) Hye-Sook Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments

(2007) Armando Piccinni et al.   JOURNAL OF AFFECTIVE DISORDERS