Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Immunology
Xu Lu, Huijun Liu, Zixuan Cai, Zhichao Hu, Minxiu Ye, Yue Gu, Yue Wang, Dan Wang, Qun Lu, Zhongxia Shen, Xinhua Shen, Chao Huang
Summary: Depressed mice have lower numbers of microglia in the dentate gyrus. Reversing this decline with a single low dose of lipopolysaccharide has antidepressant effects. The antidepressant effect is related to the synthesis and signaling pathway of brain-derived neurotrophic factor.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Danielle M. Diniz, Francesca Calabrese, Paola Brivio, Marco A. Riva, Joanes Grandjean, Judith R. Homberg
Summary: BDNF plays a crucial role in neuroplasticity, vulnerability and resilience to stress-related disorders. Modulation of BDNF levels in the ventral hippocampus of SERT-/- rats led to positive behavioral outcomes, suggesting BDNF upregulation as a potential target for new therapeutic approaches in improving depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
Article
Biotechnology & Applied Microbiology
Yuanyuan Zhang, Yong Luo, Xuenan Hou, Kang Lu, Yanhong He, Baoying Yang, Yi Qin
Summary: This study explored the effect of Xiaoyao Powder (XYP) on depression induced by chronic unpredictable mild stress (CUMS) and its underlying mechanisms. The results showed that XYP supplementation significantly reduced CUMS-induced hippocampal damage and elevated corticosterone levels. The protective effect of XYP on hippocampal neurons in CUMS-induced depression model rats was realized by up-regulating the Cx43/GR/BDNF axis.
Article
Biochemistry & Molecular Biology
Di Qu, Zichen Ye, Wenli Zhang, Bing Dai, Guo Chen, Li Wang, Xiaolong Shao, An Xiang, Zifan Lu, Juan Shi
Summary: Depression is a global disease that has a significant impact on human health. Neuroinflammation and disturbance of glutamate metabolism in brain regions, such as the hippocampus, are important factors in the development of depression. The study found that cyanidin chloride has antidepressant effects in an LPS-induced depression model by reducing hippocampal inflammation, improving function, and attenuating induced damage.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Rene Rissel, Louisa Kirchner, Miriam Renz, Katja Mohnke, Julian Riedel, Robert Ruemmler, Erik K. Hartmann, Jens Kamuf, Alexander Ziebart
Summary: This study investigated the anti-inflammatory effects of intravenous resveratrol in a porcine ARDS model. The results demonstrated that high-dose resveratrol significantly reduced TNF-alpha expression in lung tissue, increased functional residual capacity (FRC), and decreased pulmonary edema. These findings suggest the potential therapeutic use of resveratrol in ARDS.
Article
Neurosciences
Julio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Andre Vinicius Contri Paz, Clarissa S. Gama, Victorio Bambini-Junior, Mellanie Fontes-Dutra, Carmem Gottfried
Summary: This study investigated histological parameters and interneuron sub-populations in the hippocampus of an autism animal model induced by VPA, showing the protective effect of RSV. The research also demonstrated long-term effects of prenatal exposure to ASD on hippocampal structure and associated proteins.
Article
Behavioral Sciences
Xiaoju Wang, Peng Xia, Jiulong Song, Ting Yang, Changjun Yu, Kai Cheng, Anliang Chen, Xueping Li
Summary: CES improves depression-like behavior of PSD rats through upregulation of GPX4-mediated BDNF expression in the hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Chemistry, Medicinal
Fan Lin, Jiaru Chen, Mangmang Chen, Shenglei Lin, Shuangxia Dong
Summary: In this study, the efficacy of resveratrol (RES) in animal models of osteoporosis (OP) was assessed through a systematic review and meta-analysis, and the potential mechanisms were summarized. The results revealed that RES significantly increased bone mineral density, bone volume, and microstructure while reducing serum phosphorus and trabecular separation in animal OP models. Moreover, RES improved bone biomechanical indexes and decreased the structural model index. Therefore, RES has great prospects as a medicine or dietary supplement for the clinical treatment of OP.
PHYTOTHERAPY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Joeri Bordes, Lucas Miranda, Maya Reinhardt, Sowmya Narayan, Jakob Hartmann, Emily L. Newman, Lea Maria Brix, Lotte van Doeselaar, Clara Engelhardt, Larissa Dillmann, Shiladitya Mitra, Kerry J. Ressler, Benno Puetz, Felix Agakov, Bertram Mueller-Myhsok, Mathias V. Schmidt
Summary: The open-source tool DeepOF can accurately identify distinct stress-induced social behavioral patterns in mice, especially at the beginning of a novel social encounter. It provides supervised and unsupervised pipelines for analyzing pose estimation data, facilitating the study of rodent individual and social behavior.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Baohong Song, Wei Wang, Xuemei Tang, Robby Miguel Wen-Jing Goh, Win Lwin Thuya, Paul Chi Lui Ho, Lu Chen, Lingzhi Wang
Summary: Cancer metastasis is a major challenge in cancer treatment, and resveratrol has shown potential as an anticancer agent to suppress metastasis. However, progress in clinical trials has been limited. Understanding its cellular processes and signaling pathways in tumor metastasis is crucial to develop resveratrol as an effective anticancer agent. This review evaluates the current state and future development strategies of resveratrol against cancer metastasis and discusses novel techniques to accelerate its translation from bench to bedside.
Review
Pharmacology & Pharmacy
Jiajia Li, Xiaoting Zeng, Fuxun Yang, Lan Wang, Xiaoxiu Luo, Rongan Liu, Fan Zeng, Sen Lu, Xiaobo Huang, Yu Lei, Yunping Lan
Summary: Sepsis is a life-threatening organ dysfunction syndrome. Resveratrol has the potential to treat sepsis by improving survival time and reducing mortality.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Junya Onodera, Hidetaka Nagata, Ai Nakashima, Yuji Ikegaya, Ryuta Koyama
Summary: Our study demonstrated that neuronal BDNF prevents microglia from engulfing mossy fiber synapses in the hippocampus, while microglial BDNF affects the structural and functional properties of neurons.
Article
Multidisciplinary Sciences
Hossein Bakhtiari-Dovvombaygi, Saeed Izadi, Mostafa Zare, Elham Asgari Hassanlouei, Hossein Dinpanah, S. Mohammad Ahmadi-Soleimani, Farimah Beheshti
Summary: The study found that vitamin D3 administration can improve memory impairment induced by UCMS, by preventing adverse effects on Aβ, BDNF, and oxidative stress parameters.
SCIENTIFIC REPORTS
(2021)
Article
Ornithology
Bridget L. Campbell, Laura L. Hurley, Simon C. Griffith
JOURNAL OF AVIAN BIOLOGY
(2018)
Article
Biology
Laura L. Hurley, Callum S. McDiarmi, Christopher R. Friesen, Simon C. Griffith, Melissah Rowe
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2018)
Article
Physiology
Christine Elizabeth Cooper, Philip Carew Withers, Laura Leilani Hurley, Simon Charles Griffith
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Behavioral Sciences
Laura L. Hurley, Melissah Rowe, Simon C. Griffith
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
C. E. Cooper, L. L. Hurley, S. C. Griffith
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2020)
Article
Ornithology
Elizabeth L. Sheldon, Aaron. W. Schrey, Laura L. Hurley, Simon C. Griffith
JOURNAL OF AVIAN BIOLOGY
(2020)
Article
Ornithology
Simon C. Griffith, Samuel C. Andrew, Luke S. C. McCowan, Laura L. Hurley, Daisy Englert Duursma, Katherine L. Buchanan, Mylene M. Mariette
JOURNAL OF AVIAN BIOLOGY
(2020)
Article
Biology
Christine Elizabeth Cooper, Laura Leilani Hurley, Pierre Deviche, Simon Charles Griffith
JOURNAL OF EXPERIMENTAL BIOLOGY
(2020)
Article
Ornithology
Riccardo Ton, Laura L. Hurley, Simon C. Griffith
Summary: The ambient temperature can influence adult incubation behavior and offspring survival in birds. Parental behavior may buffer the effect of ambient conditions on the thermal profile of eggs to some extent.
Article
Evolutionary Biology
Elise Mccarthy, Callum S. Mcdiarmid, Laura L. Hurley, Melissah Rowe, Simon C. Griffith
Summary: The study of sperm morphology in the masked finch reveals high levels of within- and among-male variation, especially in total sperm length and specific components. Greater variance in sperm length among estrildid species suggests weak selection due to low levels of sperm competition. The findings emphasize the typical variability of sperm in estrildid species and the importance of studying closely related groups for a better understanding of sperm diversity and avian diversity.
BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
(2021)
Article
Biology
Callum S. McDiarmid, Laura L. Hurley, Madiline Le Mesurier, Andrew C. Blunsden, Simon C. Griffith
Summary: Sperm traits, including midpiece length, velocity, and motility, can be influenced by factors such as diet quality and seminal fluid composition. This study found that diet quality reduction led to a significant decrease in sperm midpiece length in wild-derived captive zebra finches. Additionally, both experimental groups showed a decrease in sperm velocity and motile sperm proportion over time, suggesting that there are other important determinants of sperm velocity.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Ornithology
Haruka Wada, Leslie Dees, Laura L. Hurley, Simon C. Griffith
Summary: Avian females can modify their nest-site selection and breeding behavior in response to changes in ambient temperature. However, their response to high ambient temperature in terms of eggshell characteristics has not been extensively studied. To address this, wild-derived and domesticated Zebra Finches were bred under temperatures of 18 degrees C, 30 degrees C, or 35 degrees C. The study found that eggs from finches bred at 18 degrees C and 30 degrees C had similar characteristics, but females exposed to 35 degrees C laid significantly thinner eggs compared to the 18 degrees C group. These findings suggest that ecologically relevant temperatures in arid regions of Australia can affect eggshell thickness, an important factor for bird hatchability.
Article
Biodiversity Conservation
Alexandra Pavlova, Sara Petrovic, Katherine A. Harrisson, Karina Cartwright, Elizabeth Dobson, Laura L. Hurley, Meagan Lane, Michael J. L. Magrath, Kimberly A. Miller, Bruce Quin, Monique Winterhoff, Jian D. L. Yen, Paul Sunnucks
Summary: Small, isolated populations face the risk of extinction due to inbreeding depression, loss of beneficial variation, and reduced adaptability. Genetic rescue through gene flow from diverse sources is the most effective way to improve their fitness. However, the use of a different subspecies as a potential source of immigrants may result in reduced fitness of mixed offspring. Test cases are necessary to evaluate and manage such risky rescues.
BIOLOGICAL CONSERVATION
(2023)
Article
Behavioral Sciences
Laura L. Hurley, Riccardo Ton, Melissah Rowe, Katherine L. Buchanan, Simon C. Griffith, Ondi L. Crino
Summary: Birds that breed opportunistically maintain partial activation of reproductive systems to rapidly exploit environmental conditions when they become suitable for breeding. Males of seasonally breeding birds downregulate testosterone production outside of a breeding context to minimize costs.
HORMONES AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Laura L. Hurley, Ondi L. Crino, Melissah Rowe, Simon C. Griffith
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)