Article
Multidisciplinary Sciences
Uriel Y. Moreno-Nieves, Joshua K. Tay, Saumyaa Saumyaa, Nina B. Horowitz, June Ho Shin, Imran A. Mohammad, Bogdan Luca, David C. Mundy, Gunsagar S. Gulati, Nikita Bedi, Serena Chang, Chen Chen, Michael J. Kaplan, Eben L. Rosenthal, F. Christopher Holsinger, Vasu Divi, Fred M. Baik, Davud B. Sirjani, Andrew J. Gentles, Aaron M. Newman, Aharon G. Freud, John B. Sunwoo
Summary: Despite the reported antitumor functions of NK cells, their contribution to tumor control in humans remains controversial due to incomplete understanding of the NK cell states within the tumor microenvironment (TME). This study demonstrates that peripheral circulating NK cells differentiate into two divergent pathways within the TME, resulting in different end states, with one having potent in vivo antitumor activity. This finding provides insight into the origin of certain NK cell states within the TME and identifies specific NK cell phenotypes with the greatest antitumor activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Xin Chen, Zixun Yu, Cheng Nong, Rufeng Xue, Mingxuan Zhang, Yiying Zhang, Lixin Sun, Luyong Zhang, Xinzhi Wang
Summary: Triptolide can activate iNKT cells in the liver, leading to liver injury. Hepatic cDCs exhibit immunogenic activities after TP administration and activate iNKT cells through IL-12, causing liver damage. TP activates the STING signaling pathway and induces ER stress, promoting the activation of cDCs and iNKT cells, resulting in hepatotoxicity.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Khiem C. Lam, Romina E. Araya, April Huang, Quanyi Chen, Martina Di Modica, Richard R. Rodrigues, Amelie Lopes, Sarah B. Johnson, Benjamin Schwarz, Eric Bohrnsen, Alexandria P. Cogdill, Catharine M. Bosio, Jennifer A. Wargo, Maxwell P. Lee, Romina S. Goldszmid
Summary: This study reveals how the microbiota influences the immune components of the TME to improve cancer therapy. Modulating the microbiota can trigger the IFN-I-NK cell-DC axis within tumors, enhancing the efficacy of immune checkpoint blockade (ICB).
Article
Biochemistry & Molecular Biology
Ildefonso Sanchez-Cerrillo, Diego Calzada-Fraile, Ana Triguero-Martinez, Marta Calvet-Mirabent, Olga Popova, Cristina Delgado-Arevalo, Mariel Valdivia-Mazeyra, Marta Ramirez-Huesca, Enrique Vazquez de Luis, Alberto Benguria, Teresa Acena-Gonzalo, Roberto Moreno-Vellisca, Magdalena Adrados de Llano, Hortensia de la Fuente, Ilya Tsukalov, Pablo Delgado-Wicke, Elena Fernandez-Ruiz, Emilia Roy-Vallejo, Reyes Tejedor-Lazaro, Almudena Ramiro, Salvador Iborra, Francisco Sanchez-Madrid, Ana Dopazo, Isidoro Gonzalez Alvaro, Santos Castaneda, Enrique Martin-Gayo
Summary: This study reveals the increased proportion of CD16(+) CD56hi NK cell subset and CD64(+) conventional dendritic cells (cDC2) in pSS patients, suggesting their involvement in the progression of the disease. The cDC2 can activate NK cells ex vivo and are found in proximity to NK cells in the salivary glands. The expression of NKG2D ligands on cDC2 from pSS patients is regulated by the IFN signatures associated with the RIG-I/DDX60 pathway. Injection of poly I:C leads to increased proportions of CD64hi RAE-1(+) cDC2 and NKG2D(+) CD11b(+) CD27(+) NK cells in the salivary glands.
Article
Chemistry, Multidisciplinary
Shuojiong Pan, Jun Guan, Banruo Xianyu, Yizheng Tan, Tianyu Li, Huaping Xu
Summary: Self-assembled selenium-containing nanoparticles are developed to reverse NK cell exhaustion and enhance NK-cell-mediated immunotherapy, effectively inhibiting tumor growth.
ADVANCED MATERIALS
(2023)
Article
Otorhinolaryngology
Shuo Yang, Zhi-Jun Yuan, Yue-Hong Zhu, Xue Chen, Wei Wang
Summary: The study revealed that lncRNA PVT1 decreases the sensitivity of HNSCC cells to cetuximab by enhancing methylation-mediated inhibition of miR-124-3p, providing a new insight into the cetuximab chemoresistance of HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Immunology
Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj
Summary: Every type of cancer tissue is more susceptible to viral infection, which has been utilized as a new anti-cancer therapy using oncolytic viruses (OVs). OVs selectively infect and destroy cancer cells while causing no harm to the host. Research focuses on the interaction between OVs and the host immune system, particularly the role of dendritic cells (DCs) and natural killer (NK) cells in the therapeutic response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hao Chi, Xixi Xie, Yingjie Yan, Gaoge Peng, Dorothee Franziska Strohmer, Guichuan Lai, Songyun Zhao, Zhijia Xia, Gang Tian
Summary: This study established a reliable signature based on genes related to NK cells in HNSCC, providing a new perspective for assessing immunotherapy response and prognosis. The 17-NRGs signature demonstrated excellent predictive performance and offered new perspectives for evaluating pre-immune efficacy, facilitating future precision immuno-oncology research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Markus Hecht, Dennis Hahn, Philipp Wolber, Matthias G. Hautmann, Dietmar Reichert, Steffi Weniger, Claus Belk, Tobias Bergmann, Thomas Goehler, Manfred Welslau, Christina Gross-Thie, Orlando Guntinas-Lichius, Jens von der Gruen, Panagiotis Balermpas, Katrin Orlowski, Diethelm Messinger, Karsten G. Stenzel, Rainer Fietkau
Summary: In locally recurrent head and neck squamous cell cancer (HNSCC) patients, radiotherapy combined with cetuximab showed better survival outcomes compared to chemotherapy combined with cetuximab.
Article
Biochemistry & Molecular Biology
Jen-Tsun Lin, Yi-Ching Chuang, Mu-Kuan Chen, Yu-Sheng Lo, Chia-Chieh Lin, Hsin-Yu Ho, Yen-Tze Liu, Ming-Ju Hsieh
Summary: This article investigated the effects of a phytochemical called Shuterin on the proliferation and activity of NK cells. The study found that Shuterin enhanced the proliferation and cytotoxicity of NK cells, and induced the expression of certain proteins and the secretion of interferon. Therefore, Shuterin represents a promising agent for promoting the immune therapy of NK cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sara Varatanovic, Stefan Stoiber, Markus Haas, Alexander Lein, Lorenz Kadletz-Wanke, Faris F. Brkic
Summary: MK0752 shows potential as a therapeutic agent for HPV-positive HNSCC by exhibiting antineoplastic effects and inducing apoptosis. Further investigation is needed to validate these findings and understand the underlying mechanisms.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Neil Shende, Jingyue Xu, Wei Tse Li, Jeffrey Liu, Jaideep Chakladar, Kevin T. Brumund, Weg M. Ongkeko
Summary: This study investigated the effects of smoking and HPV infection on eRNA expression in HNSCC tumors. The research found a substantial number of differentially expressed eRNA in each patient cohort, with some dysregulated eRNA correlated to patient survival, clinical variables, immune pathways, and genomic alterations. Additionally, dysregulated eRNA near key HNSCC-related oncogenes were identified, providing potential insights into the relationship between eRNA expression, enhancer activity, and nearby gene dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Hematology
Robin Parihar
Summary: In this study, memory-like natural killer (ML NK) cells were evaluated for their potential in treating relapsed acute myeloid leukemia (AML) patients after transplantation. The results show that ML NK cells hold promise in AML therapy, and serial assessments of blood and bone marrow provide new insights into their biology.
Article
Biochemistry & Molecular Biology
Sebastian Wimmer, Lisa Deloch, Michael Hader, Anja Derer, Fridolin Grottker, Thomas Weissmann, Markus Hecht, Antoniu-Oreste Gostian, Rainer Fietkau, Benjamin Frey, Udo S. Gaipl
Summary: Following radiotherapy, the HPV status may not distinctly predict immunological responses, highlighting the importance of individualized ICM expression in selecting patients for targeted immune therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Caihua Zhang, Zhi Chen, Nailin Gao, Gan Xiong, Peng Chen, Hui Li, Demeng Chen, Qianting He, Liang Peng
Summary: In this study, resistant Bmi1-expressing cells were found during cetuximab treatment, and a novel role of SOX18 in promoting cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) was reported. The study aimed to investigate the regulatory mechanism of Sox18 in Bmi1-positive cells and to search for better therapeutic targets.
Article
Oncology
Benjamin A. Kansy, Gulidanna Shayan, Hyun-Bae Jie, Sandra P. Gibson, Yu L. Lei, Sven Brandau, Stephan Lang, Nicole C. Schmitt, Fei Ding, Yan Lin, Robert L. Ferris
Article
Gastroenterology & Hepatology
Grace Zhang, Krupa Patel, Akshata Moghe, Andrea Reid, Marina Serper, Linda Calgaro, Sandra Gibson, Susan Zickmund, Obaid Shaikh, Shari Rogal
DIGESTIVE DISEASES AND SCIENCES
(2020)
Article
Health Care Sciences & Services
Shari S. Rogal, Vera Yakovchenko, Timothy Morgan, Jasmohan S. Bajaj, Rachel Gonzalez, Angela Park, Lauren Beste, Edward J. Miech, Carolyn Lamorte, Brittney Neely, Sandra Gibson, Patrick S. Malone, Maggie Chartier, Tamar Taddei, Guadalupe Garcia-Tsao, Byron J. Powell, Jason A. Dominitz, David Ross, Matthew J. Chinman
IMPLEMENTATION SCIENCE
(2020)
Article
Multidisciplinary Sciences
Shari S. Rogal, Vera Yakovchenko, Rachel Gonzalez, Angela Park, Carolyn Lamorte, Sandra P. Gibson, Maggie Chartier, David Ross, Emily Comstock, Jasmohan S. Bajaj, Timothy R. Morgan
Article
Oncology
Shari S. Rogal, Vera Yakovchenko, Rachel Gonzalez, Angela Park, Lauren A. Beste, Karine Rozenberg-Ben-Dror, Jasmohan S. Bajaj, Dawn Scott, Heather McCurdy, Emily Comstock, Michael Sidorovic, Sandra Gibson, Carolyn Lamorte, Anna Nobbe, Maggie Chartier, David Ross, Jason A. Dominitz, Timothy R. Morgan
Summary: The article discusses the Veterans Health Administration's national cirrhosis quality improvement program, focusing on early detection of liver cancer. After successfully eliminating Hepatitis C, efforts shifted towards improving cirrhosis care, resulting in significant improvement in HCC surveillance rates. Improved utilization of the ALD Dashboard and adoption of the HCC Clinical Reminder were associated with higher HCC surveillance rates across VHA facilities.
Article
Gastroenterology & Hepatology
Shari S. Rogal, Matthew J. Chinman, William DeMonte, Sandra Gibson, Stephanie Hoyt-Trapp, Gloria J. Klima, Naudia L. Jonassaint, Jane M. Liebschutz, Kevin L. Kraemer, Jessica Merlin
Summary: This study aimed to design a pain self-management (PSM) intervention for patients with cirrhosis. Semi-structured interviews were conducted with patients, hepatologists, and administrators to identify barriers to PSM behaviors and motivation to treat pain. Based on the findings, a 12-week phone intervention was designed.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juan Chen, Shanhong Lu, Yitao Mao, Lei Tan, Guo Li, Yan Gao, Pingqing Tan, Donghai Huang, Xin Zhang, Yuanzheng Qiu, Yong Liu
Summary: The study found that radiomics features extracted from pre-treatment MRI can predict overall survival in patients with hypopharyngeal squamous cell carcinoma. The integration of radiomics score with specific clinicopathologic factors showed improved prediction performance.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Vera Yakovchenko, Timothy R. Morgan, Edward J. Miech, Brittney Neely, Carolyn Lamorte, Sandra Gibson, Lauren A. Beste, Heather McCurdy, Dawn Scott, Rachel Gonzalez, Angela M. Park, Byron J. Powell, Jasmohan S. Bajaj, Jason A. Dominitz, Maggie Chartier, David B. Ross, Matthew J. Chinman, Shari S. Rogal
Summary: This study identified and specified implementation strategies for improving cirrhosis care through surveys, analysis, and qualitative interviews. The findings can be applied to other implementation challenges in hepatology.
Article
Public, Environmental & Occupational Health
Vera Yakovchenko, Shari S. Rogal, David E. E. Goodrich, Carolyn Lamorte, Brittney Neely, Monica Merante, Sandra Gibson, Dawn Scott, Heather McCurdy, Anna Nobbe, Timothy R. R. Morgan, Matthew J. J. Chinman
Summary: This article discusses the methods of tailoring and adapting implementation strategies for maximum effectiveness. It also introduces the adaptation of Getting To Outcomes (GTO) into Getting To Implementation (GTI) to support the selection, tailoring, and use of implementation strategies in healthcare settings.
FRONTIERS IN PUBLIC HEALTH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Vera Yakovchenko, Sandra Gibson, Jasmohan S. Bajaj, Matthew Chinman, Lauren A. Beste, Dawn Scott, Michael Sidorovic, Anna Nobbe, Heather McCurdy, Maggie Chartier, Jason A. Dominitz, Timothy R. Morgan, Shari S. Rogal
Meeting Abstract
Gastroenterology & Hepatology
Shari S. Rogal, Vera Yakovchenko, Matthew Chinman, Heather McCurdy, Dawn Scott, Michael Sidorovic, Anna Nobbe, Brittney Neely, Carolyn Lamorte, Sandra Gibson, Sharon A. McCarthy, Maggie Chartier, Jason A. Dominitz, Timothy R. Morgan
Meeting Abstract
Gastroenterology & Hepatology
Shari S. Rogal, Matthew Chinman, William Demonte, Stephanie Hoyt-Trapp, Gloria Klima, Sandra Gibson, Jane M. Liebschutz, Kevin Kraemer, Jessica Merlin
Article
Oncology
Gulidanna Shayan, Benjamin A. Kansy, Sandra P. Gibson, Raghvendra M. Srivastava, James Kyle Bryan, Julie E. Bauman, James Ohr, Seungwon Kim, Umamaheswar Duvvuri, David A. Clump, Dwight E. Heron, Jonas T. Johnson, Robert M. Hershberg, Robert L. Ferris
CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.