Review
Oncology
Morena Fasano, Carminia Maria Della Corte, Giuseppe Viscardi, Raimondo Di Liello, Fernando Paragliola, Francesca Sparano, Maria Lucia Iacovino, Anna Castrichino, Francesca Doria, Antonello Sica, Floriana Morgillo, Giuseppe Colella, Giampaolo Tartaro, Salvatore Cappabianca, Domenico Testa, Gaetano Motta, Fortunato Ciardiello
Summary: Head and neck cancers are the seventh most common cancer worldwide, with squamous cell carcinomas being the most frequent histologic subtype. The current standard treatment includes surgery or radiotherapy for early stage diseases, while locally advanced cases may require a more aggressive multi-modal approach. Anti-EGFR targeted therapy cetuximab is currently the only approved targeted therapy option, with the recent development of immune-checkpoint inhibitors providing new treatment options.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Immunology
Giacomo Oliveira, Ann Marie Egloff, Alexander B. Afeyan, Jacquelyn O. Wolff, Zexiang Zeng, Rebecca D. Chernock, Liye Zhou, Cameron Messier, Patrick Lizotte, Kathleen L. Pfaff, Kari Stromhaug, Livius Penter, Robert I. Haddad, Glenn J. Hanna, Jonathan D. Schoenfeld, Laura A. Goguen, Donald J. Annino, Vickie Jo, Peter Oppelt, Patrik Pipkorn, Ryan Jackson, Sidharth V. Puram, Randal C. Paniello, Jason T. Rich, Jason Webb, Jose P. Zevallos, Mena Mansour, Jingxin Fu, Gavin P. Dunn, Scott J. Rodig, Jessica Ley, Luc G. T. Morris, Lara Dunn, Cloud P. Paweletz, Dorina Kallogjeri, Jay F. Piccirillo, Douglas R. Adkins, Catherine J. Wu, Ravindra Uppaluri
Summary: About 50% of patients with locally advanced HNSCC experience recurrences after definitive therapy. The presurgical administration of neoadjuvant PD-1 immunotherapy results in marked pTRs within the TME. Single-cell analysis revealed that responding tumors had clonally expanded putative tumor-specific exhausted CD8(+) TILs, while nonresponding tumors exhibited exhausted clones. Revival of preexisting ZNF683+CTX+ TILs is a major mechanism of response in HNSCC.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
Mikiya Tsunoda, Hiroyasu Aoki, Haruka Shimizu, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha
Summary: Temporal analysis of T cell receptor (TCR) repertoire is important for monitoring changes in antigen-specific T cells in cancer patients. However, lack of experimental models for temporal analysis within a homogeneous population limits understanding of the relationship between TCR repertoire changes and antitumor responses. Bilateral tumor model showed highly similar T-cell clones in bilateral tumors and different patterns in draining lymph nodes, suggesting independent induction of tumor-reactive T cell clones in each lymph node.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hye-Ran Kim, Jeong-Su Park, Yasmin Fatima, Maiza Kausar, Jin-Hwa Park, Chang-Duk Jun
Summary: The study reveals that the TM domain of IGSF4 can regulate TCR avidity, enhancing the antitumor activity of cytotoxic T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Christiane S. Eberhardt, Haydn T. Kissick, Mihir R. Patel, Maria A. Cardenas, Nataliya Prokhnevska, Rebecca C. Obeng, Tahseen H. Nasti, Christopher C. Griffith, Se Jin Im, Xu Wang, Dong M. Shin, Mary Carrington, Zhuo G. Chen, John Sidney, Alessandro Sette, Nabil F. Saba, Andreas Wieland, Rafi Ahmed
Summary: The study identified different transcriptional subsets of HPV-specific CD8 T cells in HPV-positive head and neck cancer, highlighting the potential response to PD-1 blockade. Furthermore, the inclusion of E2 and E5 proteins in HPV therapeutic vaccines should be considered to elicit a broader tumor-reactive CD8 T cell response.
Article
Oncology
Glaucia Maria de Mendonca Fernandes, Vilson Serafim Junior, Ana Livia Silva Galbiatti-Dias, Leticia Antunes Muniz Ferreira, Marcia Maria Urbanin Castanhole-Nunes, Rosa Sayoko Kawasaki-Oyama, Jose Victor Maniglia, Erika Cristina Pavarino, Eny Maria Goloni-Bertollo
Summary: Head and neck cancer (HNC) has low survival rates and drug resistance due to the presence of cancer stem cells (CSCs). This study found that CSCs in HNC are more sensitive to the combination of Cetuximab and Paclitaxel drugs, and the upregulation of EGFR, TRKB, KRAS and HIF-1 alpha genes and proteins in CSCs explains the drug resistance.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Corinna Haist, Zoe Poschinski, Arthur Bister, Michele J. Hoffmann, Camilla M. Grunewald, Alexandra Hamacher, Matthias Kassack, Constanze Wiek, Kathrin Scheckenbach, Helmut Hanenberg
Summary: The study successfully generated a high-affinity EGFR CAR construct and demonstrated its efficacy and specificity in combating head and neck squamous cell carcinoma and other solid cancers.
Review
Health Care Sciences & Services
Enar Jumaniyazova, Anastasiya Lokhonina, Dzhuliia Dzhalilova, Anna Kosyreva, Timur Fatkhudinov
Summary: Head-and-neck cancers, particularly squamous cell carcinomas, are aggressive tumors with low survival rates. The immune system plays a crucial role in the development and progression of these cancers. The interactions between different cell types in the tumor microenvironment shape the structure and function of the tumor, facilitating angiogenesis, proliferation, and metastasis. Understanding these interactions is important for the development of advanced therapies for head-and-neck cancers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jiangping Li, Zhiwen Xiao, Donghui Wang, Lei Jia, Shihong Nie, Xingda Zeng, Wei Hu
Summary: Recent advancements in neoantigen research have accelerated the development of tumor immunotherapies, particularly for solid tumors, including adoptive cell therapies, cancer vaccines, and antibody-based therapies. The use of next-generation sequencing and bioinformatics technology enables the rapid identification and prediction of tumor-specific antigens, which not only provide new targets for personalized tumor immunotherapy but also serve as potential indicators for predicting tumor patient survival, prognosis, and immune checkpoint blockade response.
Article
Virology
Hanyu Pan, Xinyi Yang, Jing Wang, Huitong Liang, Zhengtao Jiang, Lin Zhao, Yanan Wang, Zhiming Liang, Xiaoting Shen, Qinru Lin, Yue Liang, Jinglong Yang, Panpan Lu, Yuqi Zhu, Min Li, Pengfei Wang, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu
Summary: HIV-specific CAR-T cells have been developed to target HIV-1 infected CD4+ T-cells expressing HIV Env proteins. The use of a 3BE CAR construct allowed for the expression of a PD-1 blocking scFv and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117. These CAR-T cells showed enhanced cytotoxic activity, proliferation capability, killing efficiency, and cytokine secretion against HIV Env+ cells compared to T cells expressing 3BNC117-CAR alone. TCR-deficient 3BE CAR-T cells effectively killed HIV Env+ cells in vivo without causing severe graft-versus-host disease in mice. This approach could be a powerful therapeutic candidate for the functional cure of HIV.
Article
Oncology
Robert L. Ferris, Jessica Moskovitz, Sheryl Kunning, Ayana T. Ruffin, Carly Reeder, James Ohr, William E. Gooding, Seungwon Kim, Brian J. Karlovits, Dario A. A. Vignali, Umamaheswar Duvvuri, Jonas T. Johnson, Daniel Petro, Dwight E. Heron, David A. Clump, Tullia C. Bruno, Julie E. Bauman
Summary: This study investigated the addition of ipilimumab to standard cetuximab-radiotherapy for the treatment of HNSCC. The results showed that the regimen was tolerable and achieved acceptable survival rates. Additionally, high expression of coinhibitory receptors on baseline tumor-infiltrating lymphocytes was associated with poorer disease-free survival.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Jean-Baptiste Guy, Sophie Espenel, Safa Louati, Arnaud Gauthier, Max-Adrien Garcia, Nicolas Vial, Celine Malesys, Dominique Ardail, Gersende Alphonse, Anne-Sophie Wozny, Claire Rodriguez-Lafrasse, Nicolas Magne
Summary: The combination therapy of ABT-199, cetuximab, and radiation showed promising results in inhibiting the proliferation, invasion, migration, and resistance to apoptosis in both non-CSC and CSC subpopulations of HNSCC, suggesting a potential new treatment strategy for locally advanced HNSCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Immunology
Yanling Liang, Qumiao Xu, Songming Liu, Jie Li, Fei Wang, Ziyi Li, Lijuan Liao, Yuting Lu, Yijian Li, Feng Mu, Hai-Xi Sun, Linnan Zhu
Summary: This study revealed the antitumor effects and multifaceted killing mechanisms of CD4(+) TCR-Ts, indicating that MHC class I-restricted CD4(+) TCR-Ts could serve as potential adoptive T cell therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kento Okamoto, Toshinori Ando, Hiroki Izumi, Susumu S. Kobayashi, Tomoaki Shintani, J. Silvio Gutkind, Souichi Yanamoto, Mutsumi Miyauchi, Mikihito Kajiya
Summary: The Hippo signaling pathway and its downstream effector YAP play a central role in cell proliferation. Dysregulation of the Hippo pathway triggers YAP hyperactivation, thereby inducing head and neck squamous cell carcinoma (HNSCC). Our findings suggest that co-targeting both AXL and EGFR represent a promising therapeutic approach in patients with EGFR-altered cancers.
Review
Immunology
Mara Cenerenti, Margaux Saillard, Pedro Romero, Camilla Jandus
Summary: The article reviews the discovery and characterization of cytotoxic CD4 T cells, and describes their mechanisms of cytotoxicity. The importance of these cells in disease conditions, particularly in cancer, is emphasized, and insights on how to exploit these cells in immunotherapy are provided.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexis Slama, Mohamed Zaatar, Muhittin Demir, Oezlem Okumus, Stefan Mattheis, Sandra Kampe, Kaid Darwiche, Stephan Lang, Clemens Aigner
Summary: The study found that in carefully selected patients, tracheal or laryngotracheal resection after previous interventions provides comparable outcomes to primary surgery.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Gastroenterology & Hepatology
Shari S. Rogal, Matthew J. Chinman, William DeMonte, Sandra Gibson, Stephanie Hoyt-Trapp, Gloria J. Klima, Naudia L. Jonassaint, Jane M. Liebschutz, Kevin L. Kraemer, Jessica Merlin
Summary: This study aimed to design a pain self-management (PSM) intervention for patients with cirrhosis. Semi-structured interviews were conducted with patients, hepatologists, and administrators to identify barriers to PSM behaviors and motivation to treat pain. Based on the findings, a 12-week phone intervention was designed.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Vera Yakovchenko, Timothy R. Morgan, Edward J. Miech, Brittney Neely, Carolyn Lamorte, Sandra Gibson, Lauren A. Beste, Heather McCurdy, Dawn Scott, Rachel Gonzalez, Angela M. Park, Byron J. Powell, Jasmohan S. Bajaj, Jason A. Dominitz, Maggie Chartier, David B. Ross, Matthew J. Chinman, Shari S. Rogal
Summary: This study identified and specified implementation strategies for improving cirrhosis care through surveys, analysis, and qualitative interviews. The findings can be applied to other implementation challenges in hepatology.
Article
Cell Biology
Ekaterina Pylaeva, Georg Korschunow, Ilona Spyra, Sharareh Bordbari, Elena Siakaeva, Irem Ozel, Maksim Domnich, Anthony Squire, Anja Hasenberg, Kruthika Thangavelu, Timon Hussain, Moritz Goetz, Karl S. Lang, Matthias Gunzer, Wiebke Hansen, Jan Buer, Agnes Bankfalvi, Stephan Lang, Jadwiga Jablonska
Summary: In this study, researchers found that tumor-associated neutrophils migrate to lymph nodes during head and neck cancer progression and play a dual role in shaping anti-tumor responses. In metastasis-free stages, neutrophils stimulate T cells, while in metastatic stages, they suppress T cell responses. The accumulation of neutrophils in lymph nodes can predict the survival rate of head and neck cancer patients.
Article
Immunology
Timon Hussain, Maksim Domnich, Sharareh Bordbari, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Irem Ozel, Freya Droege, Anthony Squire, Stefan Lienenklaus, Kathrin Sutter, Anja Hasenberg, Matthias Gunzer, Stephan Lang, Jadwiga Jablonska
Summary: Tumor-draining lymph nodes (TDLNs) are the first organs where metastatic spread of cancer occurs, and myeloid cells such as neutrophils play a crucial role in the activation of effector lymphocytes. The availability of type I interferon (IFN) influences the tumor-supportive or tumor-inhibiting activity of neutrophils. Defective type I IFN signaling leads to an impaired immunoregulatory capacity of neutrophils, resulting in enhanced tumor growth. Stimulation of IFN signaling may provide a therapeutic opportunity in head and neck cancer patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Laura Christine Holtmann, Amadea Strahlenbach, Stefan Hans, Stephan Lang, Diana Arweiler-Harbeck
Summary: The medial olivocochlear reflex (MOCR) may affect bimodal hearing in some individuals, but it is not observable in all cases. Threshold changes observed in acoustic brainstem response (ABR) measurements were reproducible in a specific subgroup, potentially due to a reactivated MOCR.
AUDIOLOGY AND NEURO-OTOLOGY
(2023)
Article
Otorhinolaryngology
Benedikt Hoeing, L. Wittig, L. Weber, B. A. Stuck, S. Mattheis, T. Hussain, S. Lang, J. M. Theysohn, Y. Li, S. Hansen
Summary: This retrospective study aimed to investigate the use of abdominal ultrasound as a staging procedure in head and neck squamous cell carcinoma (HNSCC). Out of 426 patients who received abdominal ultrasound, 7% were suspected of metastasis, with the majority being liver masses. The study found that abdominal ultrasound had a negative predictive value of 99.03% and a positive predictive value of 5.88% in HNSCC patients with N2/N3 cervical lymph node status.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Eric Deuss, Saskia Schieder, Stephan Lang, Stefan Mattheis, Orlando Guntinas-Lichius, Moritz Friedo Meyer
Summary: This survey aimed to assess the diagnostic workup and therapeutic strategies for salivary gland diseases in German otorhinolaryngology departments. The results showed diversity in the diagnosis and treatment methods, with variations in different locations.
Meeting Abstract
Oncology
T. Hussain, C. Rothkirch, S. Mattheis, S. Lang
Meeting Abstract
Oncology
C. Kuerten, A. Kulkarni, L. Vujanovic, A. Cillo, S. Lang, R. Ferris
Article
Public, Environmental & Occupational Health
Vera Yakovchenko, Shari S. Rogal, David E. E. Goodrich, Carolyn Lamorte, Brittney Neely, Monica Merante, Sandra Gibson, Dawn Scott, Heather McCurdy, Anna Nobbe, Timothy R. R. Morgan, Matthew J. J. Chinman
Summary: This article discusses the methods of tailoring and adapting implementation strategies for maximum effectiveness. It also introduces the adaptation of Getting To Outcomes (GTO) into Getting To Implementation (GTI) to support the selection, tailoring, and use of implementation strategies in healthcare settings.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemical Research Methods
Aniwat Juhong, Bo Li, Yifan Liu, Cheng-You Yao, Chia-Wei Yang, Dalen W. Agnew, Yu Leo Lei, Gary D. Luker, Harvey Bumpers, Xuefei Huang, Wibool Piyawattanametha, Zhen Qiu
Summary: Multispectral optoacoustic tomography (MSOT) is a useful technique for detailed analysis of biological samples, but it's time-consuming. This study proposes a deep learning model based on hybrid recurrent and convolutional neural networks to generate sequential cross-sectional images for MSOT. By using a larger step size for input images, the proposed model can generate additional high-resolution images, reducing acquisition time by approximately 71%.
JOURNAL OF BIOPHOTONICS
(2023)
Meeting Abstract
Immunology
M. Domnich, E. Pylaeva, E. Siakaeva, I. Spyra, I. Ozel, S. Lang, M. Pietrowska, J. Jablonska
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
E. Pylaeva, I. Spyra, I. Oezel, M. Domnich, B. Hoeing, C. Haist, H. Hanenberg, S. Lang, J. Jablonska
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Oncology
M. Pogorzelski, W. Fendler, C. Berliner, T. Hussain, S. Lang, S. Ting, K. W. Schmid, H. -U. Schildhaus, T. Gauler, M. Stuschke, K. Laue, K. Herrmann, V. Gruenwald, M. Schuler, S. Kasper-Virchow
ONCOLOGY RESEARCH AND TREATMENT
(2022)