The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth

The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis

(2017) Eva Andreuzzi et al.   MATRIX BIOLOGY

Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium

(2017) Federico Galvagni et al.   MATRIX BIOLOGY

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Targeting of EMILIN-1 and EMILIN-2 to Fibrillin Microfibrils Facilitates their Incorporation into the Extracellular Matrix

(2016) Alvise Schiavinato et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread

(2015) Ping-Pui Wong et al.   CANCER CELL

Bad vessels beware! Semaphorins will sort you out!

(2015) G. Serini et al.   EMBO Molecular Medicine

Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality

(2015) A. McIntyre et al.   EMBO Molecular Medicine

Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains

(2015) Simonetta Bot et al.   MATRIX BIOLOGY

Genetic compensation induced by deleterious mutations but not gene knockdowns

(2015) Andrea Rossi et al.   NATURE

MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth

(2015) Roberta Colladel et al.   Oncotarget

The Extracellular Matrix Glycoprotein Elastin Microfibril Interface Located Protein 2: A Dual Role in the Tumor Microenvironment

(2015) Maurizio Mongiat et al.   NEOPLASIA

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Neurotensin signaling regulates stem-like traits of glioblastoma stem cells through activation of IL-8/CXCR1/STAT3 pathway

(2014) Ji Zhou et al.   CELLULAR SIGNALLING

EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration

(2013) Stefano Marastoni et al.   JOURNAL OF PATHOLOGY

Bevacizumab in Stage II-III Colon Cancer: 5-Year Update of the National Surgical Adjuvant Breast and Bowel Project C-08 Trial

(2012) Carmen J. Allegra et al.   JOURNAL OF CLINICAL ONCOLOGY

G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils

(2012) Hoainam T. Nguyen-Jackson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-8 and CXCL10 expression in oral keratinocytes and fibroblasts via Toll-like receptors

(2012) Akiko Fukui et al.   MICROBIOLOGY AND IMMUNOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2011) Atsushi Ohtsu et al.   JOURNAL OF CLINICAL ONCOLOGY

The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation

(2011) Andrew C. Newman et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

(2011) A. Bronisz et al.   NATURE CELL BIOLOGY

MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway

(2011) E Lorenzon et al.   ONCOGENE

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data

(2010) Ilya Kupershmidt et al.   PLoS One

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

The biological properties of cetuximab

(2008) Bruno Vincenzi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Emilin1 Deficiency Causes Structural and Functional Defects of Lymphatic Vasculature

(2008) C. Danussi et al.   MOLECULAR AND CELLULAR BIOLOGY

EMILINs interact with anthrax protective antigen and inhibit toxin action in vitro

(2007) Roberto Doliana et al.   MATRIX BIOLOGY