4.7 Article

EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration

期刊

JOURNAL OF PATHOLOGY
卷 232, 期 4, 页码 391-404

出版社

WILEY
DOI: 10.1002/path.4316

关键词

-

资金

  1. ISS-ACC Program 2 [ISS-ACC/R5.5]
  2. Italian Association for Cancer Research (AIRC) [IG-2012-12718]
  3. Italian Ministry of Education, University, and Research (MIUR) [RBRN07BMCT]

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Nutrition & Dietetics

Prognostic role of visceral fat for overall survival in metastatic colorectal cancer: A pilot study

Debora Basile, Michele Bartoletti, Maurizio Polano, Lucia Bortot, Lorenzo Gerratana, Paola Di Nardo, Matteo Borghi, Valentina Fanotto, Giacomo Pelizzari, Camilla Lisanti, Mattia Garutti, Silvia Buriolla, Elena Ongaro, Eva Andreuzzi, Marcella Montico, Luca Balestreri, Gianmaria Miolo, Giuseppe Toffoli, Giuseppe Aprile, Fabio Puglisi, Angela Buonadonna

Summary: This study investigated the prognostic role of adiposity, especially visceral fat, in patients with metastatic colorectal cancer. The results showed that higher visceral fat values were associated with worse outcomes in these patients. Further research is needed to explore the impact of visceral fat on colorectal cancer patients.

CLINICAL NUTRITION (2021)

Article Biochemistry & Molecular Biology

Silvia Castagnaro, Lisa Gambarotto, Matilde Cescon, and Paolo Bonaldo

Silvia Castagnaro, Lisa Gambarotto, Matilde Cescon, Paolo Bonaldo

Summary: Autophagy is a versatile process in which cells degrade damaged proteins, organelles, or pathogens. Collagen VI deficiency triggers pathological events in skeletal muscle and other tissues, impacting key cell processes.

MATRIX BIOLOGY (2021)

Correction Cell Biology

The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction (vol 8, 580933, 2020)

Samuele Metti, Lisa Gambarotto, Martina Chrisam, Martina La Spina, Martina Baraldo, Paola Braghetta, Bert Blaauw, Paolo Bonaldo

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Advanced photodynamic therapy with an engineered M13 phage targeting EGFR: Mitochondrial localization and autophagy induction in ovarian cancer cell lines

Barbara Bortot, Maura Apollonio, Gabriele Baj, Laura Andolfi, Luisa Zupin, Sergio Crovella, Matteo di Giosia, Andrea Cantelli, Roberto Saporetti, Luca Ulfo, Annapaola Petrosino, Giovanni Di Lorenzo, Federico Romano, Giuseppe Ricci, Maurizio Mongiat, Alberto Danielli, Matteo Calvaresi, Stefania Biffi

Summary: This study proposes a bacteriophage-based receptor targeted photodynamic therapy for treating EGFR-positive ovarian cancer. The modified M13 bacteriophage with an EGFR binding peptide displayed on its surface effectively kills cancer cells through ROS generation by photosensitizers. It also downregulates EGFR expression and induces autophagy.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Article Oncology

Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway

Eva Andreuzzi, Albina Fejza, Maurizio Polano, Evelina Poletto, Lucrezia Camicia, Greta Carobolante, Giulia Tarticchio, Federico Todaro, Emma Di Carlo, Melania Scarpa, Marco Scarpa, Alice Paulitti, Alessandra Capuano, Vincenzo Canzonieri, Stefania Maiero, Mara Fornasarig, Renato Cannizzaro, Roberto Doliana, Alfonso Colombatti, Paola Spessotto, Maurizio Mongiat

Summary: This study reveals the importance of EMILIN-2 in the development and prognosis of colorectal cancer. Loss of EMILIN-2 is associated with increased tumor numbers and altered immune cell populations in CRC models. Mechanistically, EMILIN-2 regulates macrophage polarization through the Toll-like Receptor 4/MyD88/NF-kappa B pathway. Furthermore, EMILIN-2 expression levels are correlated with the prognosis of CRC patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Cell & Tissue Engineering

Emilin-2 is a component of bone marrow extracellular matrix regulating mesenchymal stem cell differentiation and hematopoietic progenitors

Francesco Da Ros, Luca Persano, Dario Bizzotto, Mariagrazia Michieli, Paola Braghetta, Mario Mazzucato, Paolo Bonaldo

Summary: This study investigates the mechanisms involved in the regulation of the bone marrow microenvironment through cell-cell and cell-matrix contacts. The researchers identified Emilin-2 as an important component of the extracellular matrix in the bone marrow. Emilin-2 expression and secretion by bone marrow mesenchymal stem cells were found to inhibit adipogenic differentiation. Additionally, the deficiency of Emilin-2 was found to impair the frequency of hematopoietic stem/progenitor cells in the bone marrow. These findings provide new insights into the role of the bone marrow extracellular matrix microenvironment in the regulation of stem cell niches and hematopoietic progenitor differentiation.

STEM CELL RESEARCH & THERAPY (2022)

Article Biochemistry & Molecular Biology

EMILIN-1 deficiency promotes chronic inflammatory disease through TGFb signaling alteration and impairment of the gC1q/a4b1 integrin interaction

Eliana Pivetta, Alessandra Capuano, Maddalena Vescovo, Eugenio Scanziani, Roberto Doliana, Maurizio Mongiat, Paola Spessotto, Andrea Vecchione, Andrea Cappelleri, Gian Luca Rampioni Vinciguerra

Summary: Alterations in ECM components, such as loss of EMILIN-1, can lead to changes in the inflammatory environment in the skin and affect the development of psoriasis. Deficiency of EMILIN-1 impairs macrophage polarization and disrupts tissue homeostasis.

MATRIX BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells

Stefano Barbera, Luisa Raucci, Giusy Tassone, Laura Tinti, Filippo Prischi, Annalisa Santucci, Maurizio Mongiat, Gian Marco Tosi, Federico Galvagni, Anna Dimberg, Cecilia Pozzi, Maurizio Orlandini

Summary: Blocking the signaling activated by the plasma membrane receptor CD93 has been shown to be useful in antiangiogenic treatment and oncotherapy. CD93 structurally exists as a dimer in endothelial cells and its oligomeric form is important for binding to its ligand Multimerin-2. Crystallographic analysis reveals the role of the C-type lectin-like and sushi-like domains in achieving a functional binding state, which provides valuable information for the development of drugs targeting CD93 in neovascular pathologies.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

Article Cell Biology

Sustained oral spermidine supplementation rescues functional and structural defects in COL6-deficient myopathic mice

Lisa Gambarotto, Samuele Metti, Matteo Corpetti, Martina Baraldo, Patrizia Sabatelli, Silvia Castagnaro, Matilde Cescon, Bert Blaauw, Paolo Bonaldo

Summary: COL6-related myopathies (COL6-RM) are inherited muscle disorders caused by mutations of COL6 genes, characterized by early-onset muscle weakness. Targeting autophagy through dietary spermidine administration has shown beneficial effects in col6a1(-/-) mice and COL6-RM patients. A 100-day-long spermidine regimen rescues muscle strength in col6a1(-/-) mice and improves mitochondria and neuromuscular junction integrity, suggesting its potential application in clinical trials for COL6-RM.

AUTOPHAGY (2023)

Article Biochemistry & Molecular Biology

Emilin2 fosters vascular stability by promoting pericyte recruitment

Albina Fejza, Lucrezia Camicia, Greta Carobolante, Evelina Poletto, Alice Paulitti, Giorgia Schinello, Emanuele Di Siena, Renato Cannizzaro, Renato V. Iozzo, Gustavo Baldassarre, Eva Andreuzzi, Paola Spessotto, Maurizio Mongiat

Summary: Angiogenesis is a complex process regulated by various factors. This study reveals the significant role of Emilin2 in pericyte physiology and vascular stabilization. Emilin2 affects multiple mechanisms involved in pericyte recruitment and vascular stability. The findings suggest that Emilin2 could be a promising marker for predicting the clinical outcome of patients with melanoma, ovarian, and potentially other forms of cancer.

MATRIX BIOLOGY (2023)

Review Immunology

The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature

Albina Fejza, Greta Carobolante, Evelina Poletto, Lucrezia Camicia, Giorgia Schinello, Emanuele Di Siena, Giuseppe Ricci, Maurizio Mongiat, Eva Andreuzzi

Summary: Immune-checkpoint inhibitors (ICIs) are important in cancer therapy, but the long-lasting therapeutic effect is only seen in a minority of patients. Therefore, finding predictive biomarkers for responsiveness to ICIs is crucial. This review systematically evaluates the literature on the relation between extracellular matrix (ECM) and ICIs efficacy, highlighting the use of ECM-derived proteolytic products as liquid biopsy-based biomarkers.

FRONTIERS IN IMMUNOLOGY (2023)

Meeting Abstract Oncology

Spry1 as a potential new hypoxia modulator in cutaneous melanoma

Barbara Montico, Giorgio Giurato, Roberto Guerrieri, Annamaria Salvati, Francesca Colizzi, Lorena Baboci, Luca Sigalotti, Alessia Covre, Michele Maio, Agostino Steffan, Tuula A. Nyman, Alessandro Weisz, Maurizio Mongiat, Eva Andreuzzi, Elisabetta Fratta

CANCER RESEARCH (2023)

Article Medicine, Research & Experimental

pCLE detects mucosal neoplastic vascular pattern in gastric linitis plastica

Mara Fornasarig, Alessandra Capuano, Stefania Maiero, Eliana Pivetta, Vincenzo Canzonieri, Claudio Belluco, Maurizio Mongiat, Renato Cannizzaro, Paola Spessotto

Summary: This study found abnormal changes in vasculature in patients with Linitis plastica (LP) using probe-based Confocal Laser Endomicroscopy (pCLE). The abnormal features included vessel enlargement, tortuosity, and leakage associated with the affected submucosal layer. This provides a new endoscopic approach and strategy for diagnosing LP.

CLINICAL AND EXPERIMENTAL MEDICINE (2023)

Meeting Abstract Gastroenterology & Hepatology

THE ECM MOLECULE EMILIN-2 AFFECTS THE INFLAMMATORY RESPONSE VIA THE TLR-4/MYD88 PATHWAY IMPACTING ON COLORECTAL CANCER PATIENTS' PROGNOSIS

E. Andreuzzi, A. Fejza, E. Poletto, L. Camicia, G. Carobolante, M. Polano, E. Di Carlo, M. Scarpa, S. Maiero, M. Fornasarig, R. Cannizzaro, M. Mongiat

DIGESTIVE AND LIVER DISEASE (2022)

暂无数据