The path to metastatic mouse models of colorectal cancer

OncogenicKrasdrives invasion and maintains metastases in colorectal cancer

(2017) Adam T. Boutin et al.   GENES & DEVELOPMENT

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

(2017) Jatin Roper et al.   NATURE BIOTECHNOLOGY

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

(2017) Kevin P O'Rourke et al.   NATURE BIOTECHNOLOGY

A recellularized human colon model identifies cancer driver genes

(2016) Huanhuan Joyce Chen et al.   NATURE BIOTECHNOLOGY

Mouse models of colorectal cancer as preclinical models

(2015) Rebecca E. McIntyre et al.   BIOESSAYS

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

(2014) William J. Faller et al.   NATURE

A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention

(2013) Roland Rad et al.   CANCER CELL

Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo

(2013) M Yu et al.   ONCOGENE

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

(2012) Sarah Schwitalla et al.   CANCER CELL

Mice Expressing Activated PI3K Rapidly Develop Advanced Colon Cancer

(2012) A. A. Leystra et al.   CANCER RESEARCH

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

(2012) K. Khazaie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new conditional Apc-mutant mouse model for colorectal cancer

(2010) E. C. Robanus-Maandag et al.   CARCINOGENESIS

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation ofp16INK4a

(2010) Linda A. S. Carragher et al.   EMBO Molecular Medicine

Generation of a Transgenic Mouse for Colorectal Cancer Research with Intestinal Cre Expression Limited to the Large Intestine

(2010) Y. Xue et al.   MOLECULAR CANCER RESEARCH

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

(2010) K. E. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-lived Min Mice Develop Advanced Intestinal Cancers through a Genetically Conservative Pathway

(2009) R. B. Halberg et al.   CANCER RESEARCH

TGF-β Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a β-Catenin-Independent Pathway

(2009) Patty Trobridge et al.   GASTROENTEROLOGY

Mouse Models of Colon Cancer

(2009) Makoto Mark Taketo et al.   GASTROENTEROLOGY

An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents

(2009) Melanie H. Kucherlapati et al.   GASTROENTEROLOGY

Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis

(2008) William M. Grady et al.   GASTROENTEROLOGY

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS