Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein

Structure, biochemistry, and biology of PAK kinases

(2017) Rakesh Kumar et al.   GENE

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

(2016) Jiayuan Wu et al.   OncoTargets and Therapy

The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics

(2016) Diego A. Vargas et al.   PLoS Computational Biology

PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma

(2015) Chenggang Li et al.   DIGESTIVE DISEASES AND SCIENCES

Lack of Evidence for PKM2 Protein Kinase Activity

(2015) Aaron M. Hosios et al.   MOLECULAR CELL

Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90–EGFR association

(2015) Y-C Yang et al.   ONCOGENE

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells

(2015) S Calabretta et al.   ONCOGENE

l-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2

(2015) Daiki Nakatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

(2015) Shruti Desai et al.   Oncotarget

SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells

(2014) Kirstie E. Keller et al.   MOLECULAR CELL

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

(2013) Yuhui Jiang et al.   MOLECULAR CELL

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Comparison of Plasma Tu-M2-PK and CA19-9 in Pancreatic Cancer

(2010) Maiken Thyregod Joergensen et al.   PANCREAS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms

(2008) S. J. Coniglio et al.   MOLECULAR AND CELLULAR BIOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE