l-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2

Hydrogen sulfide as a potent cardiovascular protective agent

(2014) Xiao-Hua Yu et al.   CLINICA CHIMICA ACTA

Native SDS-PAGE: high resolution electrophoretic separation of proteins with retention of native properties including bound metal ions

(2014) Andrew B. Nowakowski et al.   Metallomics

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

Death and Dysfunction of Transplanted  -Cells: Lessons Learned From Type 2 Diabetes?

(2013) K. J. Potter et al.   DIABETES

TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

(2013) Iseki Takamoto et al.   DIABETOLOGIA

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

First Phase Insulin Secretion and Type 2 Diabetes

(2012) K. Cheng et al.   CURRENT MOLECULAR MEDICINE

Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells

(2012) G. Tang et al.   DIABETOLOGIA

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Cysteine and obesity

(2011) Amany K. Elshorbagy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Cysteine and Obesity

(2011) Amany K. Elshorbagy et al.   Obesity

Cysteine

(2010) Fatima Cintra et al.   CHEST

From Pre-Diabetes to Type 2 Diabetes in Obese Youth: Pathophysiological characteristics along the spectrum of glucose dysregulation

(2010) F. Bacha et al.   DIABETES CARE

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population

(2010) Walter E. Gall et al.   PLoS One

Protein Markers for Insulin-Producing Beta Cells with Higher Glucose Sensitivity

(2010) Geert A. Martens et al.   PLoS One

Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women

(2010) Oliver Fiehn et al.   PLoS One

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes

(2009) Nader Botros et al.   AMERICAN JOURNAL OF MEDICINE

Changes in Insulin Secretion and Insulin Sensitivity in Relation to the Glycemic Outcomes in Subjects With Impaired Glucose Tolerance in the Indian Diabetes Prevention Programme-1 (IDPP-1)

(2009) C. Snehalatha et al.   DIABETES CARE

Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

(2009) Matthew B. Boxer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Depiction of metabolome changes in histidine-starvedEscherichia coliby CE-TOFMS

(2007) Yoshiaki Ohashi et al.   Molecular BioSystems