Article
Cell Biology
Wen-Kang Chen, Han-Jing Zhang, Ming-Xiang Zou, Cheng Wang, Yi-Guo Yan, Xin-Li Zhan, Xue-Lin Li, Wen-Jun Wang
Summary: In this study, the function of lncRNA HOTAIR in the proliferation of human nucleus pulposus (NP) cells of intervertebral disc degeneration (IDD) was investigated. The results showed that HOTAIR can suppress proliferation by directly targeting miR-130b. Additionally, HOTAIR upregulation significantly reduced CyclinD1 protein expression through the PTEN/AKT signaling pathway. These findings suggest that HOTAIR may be a potential target for the treatment of IDD.
Article
Oncology
Yu Zhou, Yuqing Wang, Mingying Lin, Daiqian Wu, Min Zhao
Summary: Our study revealed that HOTAIR acts as a ceRNA by binding to miR-214-3p, promoting cell proliferation and inhibiting apoptosis in HPV16 positive cervical cancer. The HOTAIR/miR-214-3p/Wnt/beta-catenin signaling pathway may play important regulatory roles in HPV16 positive cervical cancer. Our findings offer new insights into identifying novel biomarkers for cervical cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Yan-Ping Guo, Zhi-Feng Wang, Na Li, Qian-Qian Lei, Qiong Cheng, Li-Gang Shi, Sheng-Li Zhou, Xin-Hua Wang, Yang Sun, Ling-Fei Kong
Summary: This study found that lncRNA HOTAIR regulates RCC angiogenesis through the miR-126/EGFL7 axis, providing a new perspective on the molecular pathways of angiogenesis in RCC development and potentially serving as therapeutic targets for RCC treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Cell Biology
Xiaoping Zhang, Dan Li, Chengyou Jia, Haidong Cai, Zhongwei Lv, Bo Wu
Summary: The study reveals that OIP5-AS1 is a METTL14-regulated lncRNA that plays a crucial role in the progression of PTC, providing new insights into the regulatory mechanisms of PTC development.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Qi Zhang, Jing Pan, Donghai Xiong, Junjun Zheng, Kristi N. McPherson, Sangbeom Lee, Mofei Huang, Yitian Xu, Shu-hsia Chen, Yian Wang, Lea Hildebrandt Ruiz, Ming You
Summary: Delivery of aerosolized microRNAs targeting PD-L1 can effectively prevent the development and progression of lung cancer. In this study, aerosolized miR-138-5p and miR-200c miRNA mimics were found to inhibit B(a)P-induced lung adenomas and NTCU-induced lung squamous cell carcinomas with no detectable side effects. These miRNAs were also shown to inhibit PD-L1 expression and promote the immune response against cancer cells by increasing CD4+ and CD8+ T cells while reducing PD-1 expression and T-regulatory cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kai Chen, Yifu Hou, Rui Liao, Youzan Li, Hongji Yang, Jun Gong
Summary: Studies have shown that lncRNA SNHG6 is upregulated in HCC, promoting cell proliferation and inhibiting the targeting of E2F1 by competitively binding miR-204-5p.
Article
Multidisciplinary Sciences
Yang Yang, Jing Zhou, Wei Hong Li, Zhi Xiong Zhou, Xiao Bo Xia
Summary: NEAT1 regulated the development of EMT in diabetic retinopathy through the miR-204/SOX4 pathway, providing a reference for clinical prevention and treatment.
Article
Cell Biology
Xiaqiong Mao, Tao Ji, Aiguo Liu, Yunqi Weng
Summary: The study revealed that lncRNA SNHG22 is significantly upregulated in gastric cancer tissues and cells, promoting the proliferation and invasion of gastric cancer cells through multiple mechanisms. SNHG22 can be induced by ELK4 and binds EZH2 to suppress tumor suppressor gene expression, while also interacting with miR-200c-3p to increase Notch1 expression. The findings suggest SNHG22 as a potential biomarker for diagnosis and prognosis, as well as a target for gastric cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Shihong Chen, Wenyi Guo, Mingyang Meng, Dong Wu, Tao Zhou, Lei Wang, Jianwei Xu
Summary: This study found that SNHG1 plays a role in promoting cell proliferation, migration, invasion and epithelial-mesenchymal transition in pancreatic cancer. Furthermore, SNHG1 regulates the expression of FGFR1 through sponging miR-497, thereby further promoting the progression of pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Sihuan Zhang, Enhui Jiang, Zihong Kang, Yi Bi, Hongfei Liu, Han Xu, Zhen Wang, Chuzhao Lei, Hong Chen, Xianyong Lan
Summary: This study found that circBDP1 overexpression promotes the proliferation and differentiation of bovine preadipocytes. In addition, miR-181b and miR-204 are involved in fat development by targeting SIRT1 and TRARG1.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yue Cui, Bozhong Shi, Zijie Zhou, Bo Chen, Xiaoyang Zhang, Cong Li, Kai Luo, Zhongqun Zhu, Jinghao Zheng, Xiaomin He
Summary: A long non-coding RNA (CFRL) associated with cardiac fibrosis has been identified, which can promote the proliferation and migration of cardiac fibroblasts. Silencing CFRL significantly alleviates cardiac fibrosis and improves ventricular function. Interfering with CFRL may be considered as a multitarget strategy for treating cardiac fibrosis and heart failure.
Article
Oncology
Liyu Qian, Li Li, Yang Li, Shen Li, Bo Zhang, Yu Zhu, Bing Yang
Summary: In this study, the researchers investigated the role of LncRNA HOTAIR in breast cancer (BC) recurrence and metastasis. By analyzing miRNA and mRNA expression profile data, they found that HOTAIR can serve as an effective biomarker to distinguish BC patients with different prognosis. The study provides important insights into the pathogenesis of BC and may contribute to the identification of new therapeutic targets.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Chemistry, Multidisciplinary
Song-Yang Li, Ying Zhu, Ruo-Nan Li, Jia-Hui Huang, Kai You, Yun-Fei Yuan, Shi-Mei Zhuang
Summary: A novel long noncoding RNA called lnc-APUE was discovered, which accelerates cell proliferation in various types of cancer by binding to miR-20b and enhancing E2F1 expression. This study revealed a new axis involving HNF4 alpha/lnc-APUE/miR-20b/E2F1 in tumor cells, where HNF4 alpha repression leads to increased lnc-APUE expression and subsequent promotion of cell cycle progression and tumor growth.
Article
Cell Biology
Zekun Wang, Yaming Li, Jingwen Yang, Yiran Liang, Xiaolong Wang, Ning Zhang, Xiaoli Kong, Bing Chen, Lijuan Wang, Wenjing Zhao, Qifeng Yang
Summary: This study reveals that circ-TRIO plays a crucial role in TNBC and is associated with the recurrence and prognosis of TNBC patients. The findings demonstrate that knockdown of circ-TRIO inhibits the proliferation, migration, and invasion of TNBC cells, while overexpression of circ-TRIO has the opposite effects. Mechanistically, circ-TRIO interacts with miR-432-5p to regulate the expression of CCDC58.
CELL DEATH & DISEASE
(2022)
Article
Clinical Neurology
Fuqiang Wang, Hanlu Zhang, Guanghao Qiu, Zhiyang Li, Yun Wang
Summary: This study investigated the ceRNA network and the relationship between immune cells in patients with thymoma and myasthenia gravis. The findings suggest that the LINC00452/miR-204/CHST4 axis may regulate thymic regulatory T cells in the development of myasthenia gravis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Dong Chen, Fu-Ju Chou, Yuhchyau Chen, Hao Tian, Yaqin Wang, Bosen You, Yuanjie Niu, Chi-Ping Huang, Shuyuan Yeh, Nianzeng Xing, Chawnshang Chang
Article
Biochemistry & Molecular Biology
Guodong Liu, Xiwu Ouyang, Yin Sun, Yao Xiao, Bosen You, Yuan Gao, Shuyuan Yeh, Yixiong Li, Chawnshang Chang
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Biochemistry & Molecular Biology
Qingbo Huang, Yin Sun, Wei Zhai, Xin Ma, Donglai Shen, Songliang Du, Bosen You, Yuanjie Niu, Chi-Ping Huang, Xu Zhang, Chawnshang Chang
Article
Cell Biology
Bianjiang Liu, Yin Sun, Min Tang, Chao Liang, Chi-Ping Huang, Yuanjie Niu, Zengjun Wang, Chawnshang Chang
CELL DEATH & DISEASE
(2020)
Article
Oncology
Hao Tian, Fu-ju Chou, Jing Tian, Yong Zhang, Bosen You, Chi-Ping Huang, Shuyuan Yeh, Yuanjie Niu, Chawnshang Chang
Summary: ASC-J9 (R) can suppress prostate cancer progression via an androgen receptor-independent mechanism by altering ATF3 expression, leading to decreased PTK2 expression. Clinical and preclinical studies support the role of ATF3/PTK2 signaling in PCa progression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Zhendong Xiang, Yin Sun, Bosen You, Meng Zhang, Chiping Huang, Junfeng Yu, Xiangyun You, Denglong Wu, Chawnshang Chang
Summary: The study found that Enzalutamide-resistant prostate cancer cells can be suppressed by high doses of the androgen DHT. Targeting the BCL-XL protein can enhance the inhibitory effect of high-dose DHT on cell growth, promoting cell death.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Bosen You, Yin Sun, Jie Luo, Keliang Wang, Qing Liu, Ruizhe Fang, Bingmei Liu, Fuju Chou, Ronghao Wang, Jialin Meng, Chi-Ping Huang, Shuyuan Yeh, Chawnshang Chang, Wanhai Xu
Summary: The study suggests that androgen receptor (AR) promotes vasculogenic mimicry (VM) formation in ccRCC cells by regulating lncRNA-TANAR/TWIST1 signals, potentially impacting metastasis. This discovery provides a clue for the development of a novel anti-angiogenesis therapy to better suppress ccRCC progression.
Article
Oncology
Dongkui Gong, Yin Sun, Changcheng Guo, Tzong-jen Sheu, Wei Zhai, Junhua Zheng, Chawnshang Chang
Summary: The study revealed gender differences in RBM, with higher AR expression potentially linked to fewer RBMs by suppressing osteolytic formation. Mechanism dissection showed that AR can decrease circEXOC7 expression by enhancing transcription of DHX9, leading to suppression of CSF1 expression. Results from clinical epidemiological surveys found positive correlation between AR and miR-149-3p, and negative correlation between AR and CSF1 in AR-positive ccRCC tissues.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gang Deng, Ronghao Wang, Yin Sun, Chi-Ping Huang, Shuyuan Yeh, Bosen You, Changyong Feng, Gonghui Li, Shenglin Ma, Chawnshang Chang
Summary: Targeting androgens/androgen receptor signals can affect the invasion capability of prostate cancer and bladder cancer cells, with prostate cancer cell invasion increasing while bladder cancer cell invasion decreasing. This difference may be due to the distinct alterations in selective circular RNAs resulting from differential endogenous AR transcription, along with differential histone H3K4 methylation patterns and binding of AR to different androgen-response elements.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Meng Zhang, Yin Sun, Chi-Ping Huang, Jie Luo, Li Zhang, Jialin Meng, Chaozhao Liang, Chawnshang Chang
Summary: The study identified that lnc-OPHN1-5 plays a role in increasing prostate cancer sensitivity to Enzalutamide by regulating AR protein expression. The mechanism involves lnc-OPHN1-5 interacting with AR-mRNA to influence ribosome association and translation by modulating hnRNPA1.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Kuo-Chung Lan, Kuo-Ting Wei, Pei-Wen Lin, Ching-Chen Lin, Pei-Ling Won, Ya-Fen Liu, Yun-Ju Chen, Bi-Hua Cheng, Tien-Min G. Chu, Jia-Feng Chen, Ko-En Huang, Chawnshang Chang, Hong-Yo Kang
Summary: The study found that androgen receptor (AR) is highly expressed in periosteum cells during bone fracture repair and is co-localized with a mesenchymal progenitor cell marker, Prrx1. Mice lacking AR in periosteum showed reduced callus size and new bone volume. Targeting the androgen/AR axis in periosteum may provide a novel therapy approach to improve fracture healing.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Jie Ding, Xin-Gang Cui, Hao-Jie Chen, Yin Sun, Wei-Wei Yu, Jie Luo, Guang-Qian Xiao, Chawnshang Chang, Jun Qi, Shuyuan Yeh
Summary: Vasculogenic mimicry (VM), an alternative channel for tumor nutrient supply, is associated with poor prognosis in renal cell carcinoma (RCC). Sunitinib, a tyrosine kinase inhibitor (TKI), has been reported to induce VM formation by up-regulating estrogen receptor beta (ERβ) expression. This study showed that treatment with sunitinib and another TKI, axitinib, also induced ERβ expression in RCC cell lines. Clinical RCC patients with higher ERβ expression were more likely to have VM. Mechanistically, TKI-induced ERβ up-regulated the circular RNA DGKD, which enhanced VM formation by increasing VE-cadherin expression. Targeting circDGKD intercepted sunitinib-induced RCC VM formation and improved survival in an animal model.
Article
Cell Biology
Lei Chen, Yin Sun, Min Tang, Denglong Wu, Zhendong Xiang, Chi-Ping Huang, Bosen You, Dongdong Xie, Qinglin Ye, Dexin Yu, Chawnshang Chang
Summary: This study found that high-dose androgens can suppress the growth of Enzalutamide-resistant (EnzR) castration-resistant prostate cancer (CRPC) cells. The mechanism involves the transcriptional regulation of the circRNA-BCL2 host gene BCL2, which in turn affects the expression of miRNA-198 and modulates the expression of AMBRA1. This leads to the induction of autophagic cell death and the suppression of EnzR CRPC cell growth.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Yang Yang, Jindong Sheng, Shuai Hu, Yun Cui, Jing Xiao, Wei Yu, Jing Peng, Wenke Han, Qun He, Yu Fan, Yuanjie Niu, Jun Lin, Ye Tian, Chawnshang Chang, Shuyuan Yeh, Jie Jin
Summary: This study identified the histopathological characteristics and molecular mechanisms underlying accelerated progression of benign prostatic hyperplasia (BPH). Increased stromal components and prostatic fibrosis, accompanied by higher myofibroblast accumulation and collagen deposition, were found to be the main features of accelerated progressive BPH tissues. Mechanism dissection revealed that higher expression of CYP19 and G protein-coupled estrogen receptor (GPER) with higher estrogen biosynthesis contribute to the progression of BPH. Targeting the CYP19/estrogen/GPER/G alpha i signaling axis may provide new personalized therapeutics for better suppressing the progression of BPH.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Fu-Ju Chou, ChangYi Lin, Hao Tian, WanYing Lin, Bosen You, Jieyang Lu, Deepak Sahasrabudhe, Chi-Ping Huang, Vanessa Yang, Shuyuan Yeh, Yuanjie Niu, Chawnshang Chang
CELL DEATH & DISEASE
(2020)