How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations

A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cells to Drugs Impairing BRCA1-Mediated DNA Repair

(2017) Rossella Parrotta et al.   Journal of Thoracic Oncology

Inflammation-Related IL1 /IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma

(2016) Y. Kadariya et al.   Cancer Prevention Research

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

(2016) Leonid Cherkassky et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer

(2016) Emmanuel Zervos et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages

(2016) Anne-Laure Chéné et al.   Journal of Thoracic Oncology

Pleural Effusion of Patients with Malignant Mesothelioma Induces Macrophage-Mediated T Cell Suppression

(2016) Lysanne A. Lievense et al.   Journal of Thoracic Oncology

Malignant Mesothelioma Effusions Are Infiltrated by CD3 + T Cells Highly Expressing PD-L1 and the PD-L1 + Tumor Cells within These Effusions Are Susceptible to ADCC by the Anti–PD-L1 Antibody Avelumab

(2016) Swati Khanna et al.   Journal of Thoracic Oncology

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

(2016) Raphael Bueno et al.   NATURE GENETICS

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

(2016) E. L. Soucie et al.   SCIENCE

Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line

(2015) Walter Blum et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

An RNA editing fingerprint of cancer stem cell reprogramming

(2015) Leslie A Crews et al.   Journal of Translational Medicine

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma

(2015) A Napolitano et al.   ONCOGENE

Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors

(2015) N Echeverry et al.   Cell Death & Disease

Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications

(2014) M. B. Suraokar et al.   ANNALS OF ONCOLOGY

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

CD90(+)CD45(−) intraperitoneal mesothelial-like cells inhibit T cell activation by production of arginase I

(2014) Joji Kitayama et al.   CELLULAR IMMUNOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification

(2014) S. Musah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry

(2013) R. Dixit et al.   DEVELOPMENT

Accurate Detection of Copy Number Changes in DNA Extracted from Formalin-Fixed, Paraffin-Embedded Melanoma Tissue Using Duplex Ratio Tests

(2013) David A. Moore et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

(2013) Leilei Chen et al.   NATURE MEDICINE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug

(2013) J A Tamminen et al.   Oncogenesis

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

(2012) Y. Shi et al.   CLINICAL CANCER RESEARCH

NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma

(2012) Melvyn T Chow et al.   IMMUNOLOGY AND CELL BIOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

(2012) Makiko Fujii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CTLA-4 Blockade Expands Infiltrating T Cells and Inhibits Cancer Cell Repopulation during the Intervals of Chemotherapy in Murine Mesothelioma

(2012) L. Wu et al.   MOLECULAR CANCER THERAPEUTICS

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs and their vasculature

(2012) Yuval Rinkevich et al.   NATURE CELL BIOLOGY

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes

(2012) T Mizuno et al.   ONCOGENE

Syntenic Relationships between Genomic Profiles of Fiber-Induced Murine and Human Malignant Mesothelioma

(2011) Didier Jean et al.   AMERICAN JOURNAL OF PATHOLOGY

Circulating and tumor-infiltrating myeloid cells predict survival in human pleural mesothelioma

(2011) Bryan M. Burt et al.   CANCER

Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy

(2011) Eric Tartour et al.   CANCER AND METASTASIS REVIEWS

Pleural mesothelioma side populations have a precursor phenotype

(2011) Claudia Frei et al.   CARCINOGENESIS

Structural Analysis of the Cancer-specific Promoter in Mesothelin and in Other Genes Overexpressed in Cancers

(2011) Yunzhao R. Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Cell Repopulation between Cycles of Chemotherapy is Inhibited by Regulatory T-Cell Depletion in a Murine Mesothelioma Model

(2011) Licun Wu et al.   Journal of Thoracic Oncology

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

(2011) Matthew Bott et al.   NATURE GENETICS

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

(2010) Joris D Veltman et al.   BMC CANCER

MexTAg mice exposed to asbestos develop cancer that faithfully replicates key features of the pathogenesis of human mesothelioma

(2010) Cleo Robinson et al.   EUROPEAN JOURNAL OF CANCER

Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration

(2010) R. Carmona et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conditional Mouse Model for Malignant Mesothelioma

(2008) Johan Jongsma et al.   CANCER CELL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE