Article
Oncology
Sara Busacca, Laura O'Regan, Anita Singh, Annabel J. Sharkey, Alan G. Dawson, Joanna Dzialo, Aimee Parsons, Neelam Kumar, Laurel M. Schunselaar, Naomi Guppy, Apostolos Nakas, Michael Sheaff, Aaron S. Mansfield, Sam M. Janes, Paul Baas, Andrew M. Fry, Dean A. Fennell
Summary: Loss of BRCA1 and MAD2L1 expression may serve as a predictive marker of resistance to vinorelbine in mesothelioma, potentially impacting treatment efficacy.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Oncology
Liwen Zhu, Xinyu Li, Diandian Liu, Wenke Bai, Huaqing Yang, Qianyi Cheng, Luhong Xu, Jianpei Fang
Summary: This study uncovered a reciprocal loop of MAD2L1/TYK2/STAT3, which contributed to the development of B-ALL. Therefore, MAD2L1 can be considered a potential diagnostic biomarker as well as a novel therapeutic target for B-ALL.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kenneth P. Seastedt, Nathanael Pruett, Chuong D. Hoang
Summary: This article discussed available mouse models for mesothelioma drug discovery and development, pointing out advantages and disadvantages of each model. It also highlighted gaps in current knowledge of mesothelioma and considered future directions for mouse model research. Additionally, the potential of CRISPR-Cas gene-editing in improving understanding of mesothelioma mechanisms was emphasized.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Anand Singh, Nathanael Pruett, Roma Pahwa, Arushi P. Mahajan, David S. Schrump, Chuong D. Hoang
Summary: The study investigated the therapeutic role of miR-206 in malignant pleural mesothelioma, demonstrating its ability to inhibit cell growth and showing potential therapeutic advantages when combined with other drugs.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Zhenying Guo, Li Shen, Ningning Li, Xiaoxiao Wu, Canming Wang, Zheng Gu, Zhongjian Chen, Junping Liu, Weimin Mao, Yuchen Han
Summary: This study used bioinformatics to identify key genes in malignant mesothelioma, finding that Aurora-A could be an optimal diagnostic biomarker and a potential prognostic marker. Additionally, seven genes were identified as potential prognostic markers for MM.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Yuliang Xu, Lilin Qian, Min Fang, Yue Liu, Ze-Jun Xu, Xiaoyan Ge, Zhiyue Zhang, Zhao-Peng Liu, Hongxiang Lou
Summary: Researchers have developed self-assembled nanomicelles composed of Epo B and carbohydrate molecules, which are converted to active Epo B within the tumor and show significant anticancer efficacy and selectivity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Reproductive Biology
Emily Girka, Lauren Gatenby, Emilio J. Gutierrez, Kenneth R. Bondioli
Summary: This study aimed to improve meiotic spindle recovery in vitrified bovine oocytes by investigating the effects of treatment with a microtubule stabilizing agent or a microtubule recovery agent. The results showed that treatment with paclitaxel at a certain concentration significantly increased the proportion of oocytes with normal microtubule distribution and chromosome arrangement after warming. Additionally, inhibiting rho-associated coiled-coil kinase activity and accumulation of cysteine and cysteamine also improved meiotic spindle recovery in vitrified oocytes.
Article
Biochemistry & Molecular Biology
P. Priyamvada, Sudha Ramaiah
Summary: Colorectal cancer is a challenging cancer with limited targeted therapy options. This study identified potential biomarkers for colorectal cancer through molecular interaction analysis and explored their correlation and survival impact. The findings contribute to a better understanding of the pathophysiological mechanisms underlying colorectal cancer development and offer new possibilities for diagnosis and treatment.
BIOCHEMICAL GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Arnab Mukherjee, Prethi Bhaskar Acharya, Akshita Singh, Mukunthan Kuppusamy Selvam
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the lack of efficient treatment techniques and late-stage diagnosis contribute to its increasing worldwide burden. Small non-coding RNA (miRNAs) are gaining attention as protein translation inhibitors that can degrade or suppress specific gene transcripts, making them a promising strategy for oncogenes or tumor suppression. Research focused on combining miRNAs with the drug Arsenic, which has been used to treat various diseases including cancer, to study cellular responses and their interaction with biological targets. The study revealed a link between miRNA and sterol, cholesterol, and lipid metabolic processes based on analysis of gene expression data. Further investigation using network pharmacology approach identified hsa-mir-335-5p as a negative regulator of important nodes involved in the transport and utilization of essential compounds for cancer cell growth and proliferation. The study also validated the binding association between hsa-mir-335-5p and its target genes through analysis of binding energies. The molecular interactions between hsa-mir-335-5p and the Argonaute protein in the RNA induced silencing complex were investigated, suggesting its potential application in in vitro studies.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Cell Biology
Fuli Li, Tinglei Huang, Yao Tang, Qingli Li, Jianzheng Wang, Xiaojiao Cheng, Wenhui Zhang, Baiwen Zhang, Cong Zhou, Shuiping Tu
Summary: UTD1, a novel microtubule stabilizing agent, has shown significant anti-tumor activity in colorectal cancer by inhibiting cell proliferation, inducing cell cycle arrest in G2/M phase, and triggering apoptosis. Additionally, UTD1 exhibits a stronger apoptosis-inducing effect in ABCB1 high-expression cells.
CELL DEATH & DISEASE
(2021)
Review
Biotechnology & Applied Microbiology
Rounak Chourasia, Srichandan Padhi, Loreni Chiring Phukon, Md Minhajul Abedin, Ranjana Sirohi, Sudhir P. Singh, Amit Kumar Rai
Summary: Betacoronaviruses have caused major viral outbreaks in the last two decades, and peptides have shown potential as targets for preventing infection and spread. However, challenges such as proteolytic susceptibility and low bioavailability need to be addressed for the development of peptide-based therapeutics.
Article
Engineering, Biomedical
Alicja Zajdel, Adam Wilczok, Katarzyna Jelonek, Anna Kaps, Monika Musial-Kulik, Janusz Kasperczyk
Summary: The combination of epothilone B and rapamycin showed a significant decrease in cell metabolic activity and increased cytotoxicity against breast cancer cells, when delivered in bioresorbable micelles. This dual drug-loaded micelles may be promising for targeted delivery in breast cancer treatment.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Pathology
Derek M. van Pel, Simon Cheung, Diana N. Ionescu, Andrew Churg
Summary: Distinguishing between mesothelioma and non-small cell lung carcinoma often requires multiple immunohistochemical stains, but UpIIIb has been identified as a potentially specific marker for mesothelioma. UpIIIb shows good sensitivity and specificity in distinguishing between epithelioid mesothelioma and non-small cell lung carcinoma. However, UpIIIb does not stain sarcomatoid mesothelioma and also stains a proportion of high-grade serous ovarian carcinomas.
Review
Pharmacology & Pharmacy
Jean-Baptiste Assie, Didier Jean
Summary: Pleural mesothelioma is a rare and aggressive cancer with a devastating prognosis and limited treatment options. Significant advancements have been made in the management of this disease, with nivolumab and ipilimumab immune checkpoint inhibitors becoming the new standard of care for first-line treatment.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Oncology
Jing Liu, Ying Zuo, Gui-Mei Qu, Xiao Song, Zhong-Hui Liu, Ting-Guo Zhang, Zhu-Hua Zheng, Hong-Kun Wang
Summary: The study found that CypB is upregulated in endometrial cancer, and inhibiting CypB expression can significantly suppress cell proliferation, metastasis, and migration. Gene ontology and KEGG pathway enrichment analysis indicated that genes related to CypB are mainly enriched in cell cycle, glycosphingolipid biosynthesis, adherens junctions, and metabolism pathways.
Article
Computer Science, Information Systems
Nan Zhou, Jack Y. B. Lee
Summary: This work proposes a new centralized flow-based scheduling scheme called CAPTON for over-subscribed datacenter networks, which avoids congestion by scheduling flows based on remaining flow size and link capacities. CAPTON maximizes resource utilization by utilizing all available paths and redundant links, and it can be deployed in current datacenters equipped with commodity switches without additional support from network switches.
Article
Oncology
Luana Guimaraes de Sousa, Kimal Rajapakshe, Jaime Rodriguez Canales, Renee L. Chin, Lei Feng, Qi Wang, Tomas Z. Barrese, Erminia Massarelli, William William, Faye M. Johnson, Renata Ferrarotto, Ignacio Wistuba, Cristian Coarfa, Jack Lee, Jing Wang, Cornelis J. M. Melief, Michael A. Curran, Bonnie S. Glisson
Summary: The combination of ISA101 and nivolumab shows promising long-term clinical outcomes in patients with incurable HPV-16(+) cancer. Increased infiltration of CD8(+) T cells and macrophages is predictive of treatment response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Maya Hassane, Zahraa Rahal, Nareg Karaoghlanian, Jiexin Zhang, Ansam Sinjab, Justin W. Wong, Wei Lu, Paul Scheet, J. Jack Lee, Maria Gabriela Raso, Luisa M. Solis, Junya Fujimoto, Hassan Chami, Alan L. Shihadeh, Humam Kadara
CANCER PREVENTION RESEARCH
(2022)
Article
Oncology
Xiuning Le, Frederico O. Gleber-Netto, M. Laura Rubin, Yun Qing, Robyn Du, Merrill Kies, George Blumenschein, Charles Lu, Faye M. Johnson, Diana Bell, Jeff Lewis, Jiexin Zhang, Lei Feng, Kaye Wilson, Kathrina Marcelo-Lewis, Jing Wang, Lawrence Ginsberg, Maura Gillison, J. Jack Lee, Funda Meric-Berstam, Gordon B. Mills, William N. William, Jeffrey N. Myers, Curtis R. Pickering
Summary: This study compared the efficacy of neoadjuvant erlotinib with platinum-docetaxel versus placebo with platinum-docetaxel in patients with oral squamous cell carcinoma (OSCC). The results showed that neoadjuvant erlotinib did not significantly improve major pathologic response rate, overall survival, or progression-free survival. However, patients who received erlotinib and achieved major pathologic responses had excellent clinical outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Pedro Rocha, Jiexin Zhang, Raquel Laza-Briviesca, Alberto Cruz-Bermudez, Neus Bota-Rabassedas, Beatriz Sanchez-Espiridon, Katsuhiro Yoshimura, Carmen Behrens, Wei Lu, Ximing Tang, Apar Pataer, Edwin R. Parra, Cara Haymaker, Junya Fujimoto, Stephen G. Swisher, John Heymach, Don L. Gibbons, J. Jack Lee, Boris Sepesi, Tina Cascone, Luisa M. Solis, Mariano Provencio, Ignacio I. Wistuba, Humam Kadara
Summary: This study explores immune gene programs related to tumor immunity and response to neoadjuvant chemotherapy and chemoimmunotherapy in resectable NSCLC. The findings highlight the importance of specific immune signatures and pathways in predicting treatment response.
CLINICAL CANCER RESEARCH
(2022)
Article
Computer Science, Interdisciplinary Applications
Konstantinos G. Lyras, Jack Lee
Summary: This study investigates the impact of red blood cell aggregation on hemodynamics by using multiphase simulations. The results show that red blood cell aggregation leads to a decrease in pressure, as well as changes in secondary flow patterns, red blood cell distribution, shear stresses, and velocity.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Medicine, Research & Experimental
Rui (Sammi) Tang, Jian Zhu, Tai-Tsang Chen, Fang Liu, Xun Jiang, Bo Huang, J. Jack Lee, Robert A. Beckman
Summary: This study simulated oncology trials to assess the impact of the COVID-19 pandemic and discuss potential strategies for mitigation. The results showed that COVID-19 can have a significant impact on trial outcomes, including power loss and underestimation of treatment effect size. Therefore, adjustments and improvements need to be made in trial design and data collection.
CONTEMPORARY CLINICAL TRIALS
(2022)
Article
Computer Science, Interdisciplinary Applications
Konstantinos G. Lyras, Jack Lee
Summary: This article presents a finite volume method for simulating two-phase flows with sharp fluid interfaces using a level set approach coupled with volume of fluid method. The method achieves efficiency by calculating the interface to satisfy mass conservation without explicit interface reconstruction. The algorithm provides good accuracy and mass conservation.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS
(2022)
Article
Multidisciplinary Sciences
Omar Alhalabi, Jianfeng Chen, Yuxue Zhang, Yang Lu, Qi Wang, Sumankalai Ramachandran, Rebecca Slack Tidwell, Guangchun Han, Xinmiao Yan, Jieru Meng, Ruiping Wang, Anh G. Hoang, Wei-Lien Wang, Jian Song, Lidia Lopez, Alex Andreev-Drakhlin, Arlene Siefker-Radtke, Xinqiao Zhang, William F. Benedict, Amishi Y. Shah, Jennifer Wang, Pavlos Msaouel, Miao Zhang, Charles C. Guo, Bogdan Czerniak, Carmen Behrens, Luisa Soto, Vassiliki Papadimitrakopoulou, Jeff Lewis, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, Jack Lee, Jack Roth, Stephen Swisher, Ignacio Wistuba, John Heymach, Jing Wang, Matthew T. Campbell, Eleni Efstathiou, Mark Titus, Christopher J. Logothetis, Thai H. Ho, Jianjun Zhang, Linghua Wang, Jianjun Gao
Summary: This study demonstrates a synthetic lethal interaction between MTAP(def) and antifolates, and shows that MTAP(def) urothelial carcinoma patients have a higher response rate to pemetrexed.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Parijatham S. Thomas, Anisha B. Patel, J. Jack Lee, Diane D. Liu, Mike Hernandez, Miguel Muzzio, Alejandro Contreras, Valerie Sepeda, Carrie Mays, Diane Weber, Lana A. Vornik, Seema A. Khan, Eileen Dimond, Brandy M. Heckman-Stoddard, Marjorie Perloff, Powel H. Brown
Summary: There is currently a lack of agents that can reduce the incidence of hormone receptor negative breast cancer. Rexinoids, such as bexarotene, have shown significant reduction in mammary tumor development in preclinical mouse models. This study evaluated the safety and toxicity of topical bexarotene 1% gel in high-risk women for breast cancer, as well as its concentrations in the plasma and breast tissue.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Yoshihiko Hirohashi, Tomohisa Furuhata, Ichiro Takemasa, Prabhudas Patel, Hemangini Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Takayuki Yoshino, Hiroya Taniguchi, Carlo Bifulco, Alessandro Lugli, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Borger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Gruetzmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Leonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe Masucci, Emilia Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Florence Marliot, Tessa Fredriksen, Benedicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn Van de Water, Shannon Van Lent-van Vliet, Nikki Knijn, Ana-Maria Muaina, Dragos-Viorel Scripcariu, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pages, Yutaka Kawakami, Jerome Galon
Summary: This study evaluated the prognostic value of Immunoscore in Asian patients with stage I-III colon cancer. The findings demonstrated a significant association between high Immunoscore and prolonged survival in this population.
Article
Engineering, Electrical & Electronic
Yifu Huang, Reed Hopkins, David Janosky, Ying-Chen Chen, Yao-Feng Chang, Jack C. Lee
Summary: This article extensively studies the influence of temperature instability on resistive memory switching in potential neuromorphic computing applications. The evaluation results show that ambient temperature can degrade the accuracy of neural networks.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Oncology
Muhammad Aminu, Divya Yadav, Lingzhi Hong, Elliana Young, Paul Jr Jr Edelkamp, Maliazurina Saad, Morteza Salehjahromi, Pingjun Chen, Sheeba J. Sujit, Melissa M. Chen, Bradley Sabloff, Gregory Gladish, Patricia M. de Groot, Myrna C. B. Godoy, Tina Cascone, Natalie Vokes, Jianjun Zhang, Kristy K. Brock, Naval Daver, Scott E. Woodman, Hussein A. Tawbi, Ajay Sheshadri, J. Jack Lee, David Jaffray, Carol C. Wu, Caroline Chung, Jia Wu
Summary: Cancer patients have a higher risk of COVID-19 complications and their radiologic abnormalities differ from the general population. This study developed a habitat imaging technique for COVID-19 severity prediction in cancer patients and compared it with the general population. The AI models trained on the cancer cohort outperformed those trained on the general population.
Article
Oncology
Bernhard Mlecnik, Alessandro Lugli, Gabriela Bindea, Florence Marliot, Carlo Bifulco, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Borger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grutzmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Leonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe Masucci, Emilia K. Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Benedicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon Van Lent-van Vliet, Nikki Knijn, Ana-Maria Musing, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Prabhu Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pages, Jerome Galon
Summary: This study found that the immune system status is a better predictor of prognosis in early-stage colon cancer patients than tumor cell-related parameters. The consensus Immunoscore accurately identifies early-stage colon cancer patients with different clinical outcomes, regardless of treatment bias.
Meeting Abstract
Oncology
Yufei Liu, Waree Rinsurongkawong, Carl Gay, Jeff Lewis, Vadeerat Rinsurongkawong, Jack Lee, Percy Lee, Jianjun Zhang, Don Gibbons, Ara Vaporciyan, John Heymach, Steven Lin
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)