Article
Medicine, General & Internal
H. Pottel, J. Bjork, A. D. Rule, N. Ebert, B. O. Eriksen, L. Dubourg, E. Vidal-Petiot, A. Grubb, M. Hansson, E. J. Lamb, K. Littmann, C. Mariat, T. Melsom, E. Schaeffner, P. -O. Sundin, A. Akesson, A. Larsson, E. Cavalier, J. B. Bukabau, E. K. Sumaili, E. Yayo, D. Monnet, M. Flamant, U. Nyman, P. Delanaye
Summary: The study developed a cystatin C-based equation (EKFC eGFRcys) to estimate glomerular filtration rate (GFR). This equation had similar accuracy to a creatinine-based equation (EKFC eGFRcr) and outperformed other commonly used equations. Furthermore, taking the arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of GFR estimation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Peripheral Vascular Disease
Christine Y. Bakhoum, Matthew B. Matheson, Jason H. Greenberg, Susan L. Furth, Joachim H. Ix, Pranav S. Garimella
Summary: The study found no association between urine uromodulin levels and blood pressure in children with chronic kidney disease. Further research is needed to confirm this finding in healthy pediatric cohorts.
Article
Biochemistry & Molecular Biology
Sangjung Park, Hyun-Seok Jin
Summary: This study replicated the association between three SNPs in the IGF1R gene and kidney function-related traits in Koreans. It was found that these SNPs were significantly correlated with blood urea nitrogen, creatinine, and estimated glomerular filtration rate. Additionally, two SNPs were identified to have the potential to affect IGF1R expression.
Review
Physiology
Paul J. Besseling, Tobias T. Pieters, Isabel T. N. Nguyen, Petra M. de Bree, Nel Willekes, Adele H. Dijk, Dominique M. Bovee, Ewout J. Hoorn, Maarten B. Rookmaaker, Karin G. Gerritsen, Marianne C. Verhaar, Hendrik Gremmels, Jaap A. Joles
Summary: A plasma creatinine- and plasma urea-based equation has been developed and validated for estimating GFR in rats, providing an easy and repeatable method. However, the equation is less accurate in rats with nonsteady-state creatinine.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Transplantation
Pierre Delanaye, Emmanuelle Vidal-Petiot, Jonas Bjork, Natalie Ebert, Bjorn O. Eriksen, Laurence Dubourg, Anders Grubb, Magnus Hansson, Karin Littmann, Christophe Mariat, Toralf Melsom, Elke Schaeffner, Per-Ola Sundin, Arend Bokenkamp, Ulla B. Berg, Kajsa Asling-Monemi, Anna Akesson, Anders Larsson, Etienne Cavalier, R. Neil Dalton, Marie Courbebaisse, Lionel Couzi, Francois Gaillard, Cyril Garrouste, Lola Jacquemont, Nassim Kamar, Christophe Legendre, Lionel Rostaing, Thomas Stehle, Jean-Philippe Haymann, Luciano da Silva Selistre, Jorge P. Strogoff-de-Matos, Justine B. Bukabau, Ernest K. Sumaili, Eric Yayo, Dagui Monnet, Ulf Nyman, Hans Pottel, Martin Flamant
Summary: This study compared and validated the performance of the new Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPIAS) with the European Kidney Function Consortium (EKFC) and Lund-Malmo Revised (LMREV) equations in European and African cohorts. The results showed that the EKFC equation had the best performance in both European and African populations, while CKD-EPIAS had suboptimal performance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Nori J. L. Smeets, Joanna IntHout, Maurice J. P. van der Burgh, George J. Schwartz, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study establishes reference values for GFR in healthy, term-born neonates through an analysis of individual participant data (IPD). The study also optimizes the estimation of GFR using creatinine levels. The findings reveal a biphasic increase in GFR in neonates, with the largest increase occurring between days 1 and 5 after birth.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Lesley A. Inker, Nwamaka D. Eneanya, Josef Coresh, Hocine Tighiouart, Dan Wang, Yingying Sang, Deidra C. Crews, Alessandro Doria, Michelle M. Estrella, Marc Froissart, Morgan E. Grams, Tom Greene, Anders Grubb, Vilmundur Gudnason, Orlando M. Gutierrez, Roberto Kalil, Amy B. Karger, Michael Mauer, Gerjan Navis, Robert G. Nelson, Emilio D. Poggio, Roger Rodby, Peter Rossing, Andrew D. Rule, Elizabeth Selvin, Jesse C. Seegmiller, Michael G. Shlipak, Vicente E. Torres, Wei Yang, Shoshana H. Ballew, Sara J. Couture, Neil R. Powe, Andrew S. Levey
Summary: New equations for estimating GFR without considering race, using cystatin C and creatinine, reduce estimation errors between Black and non-Black participants. Compared to equations using creatinine alone, the new equations without race are more accurate and result in smaller differences between race groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Pediatrics
Maria D. Politis, Jacob C. Freedman, Erin N. Haynes, Alison P. Sanders
Summary: The study found no clear associations between blood manganese concentrations and kidney parameters or blood pressure, but a positive correlation was observed between urine manganese concentrations and estimated glomerular filtration rate. These exploratory findings should be interpreted cautiously and further investigated in longitudinal studies.
Article
Urology & Nephrology
Luciano Selistre, Vandrea de Souza, Carla Nicola, Laurent Juillard, Sandrine Lemoine, Laurence Derain-Dubourg
Summary: A study compared the performance of mCl(UN-cr) with CKD-EPI equations in estimating eGFR and found that mCl(UN-cr) performed similarly to CKD-EPI equations and had better performance at mGFR <60 mL/min/1.73 m(2).
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Gregory L. Hundemer, Christine A. White, Patrick A. Norman, Greg A. Knoll, Navdeep Tangri, Manish M. Sood, Swapnil Hiremath, Kevin D. Burns, Christopher McCudden, Ayub Akbari
Summary: This study validated the 2021 race-free CKD-EPI eGFR equations among kidney transplant recipients, finding that they performed similarly to previous equations that included race correction terms. There was no significant difference in performance between the 2021 CKD-EPI eGFRcr and eGFRcr-cys equations in the kidney transplant population.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Editorial Material
Urology & Nephrology
Bessie A. Young
Summary: Two studies suggest that cystatin-C-based equations can accurately estimate glomerular filtration rate regardless of race, addressing concerns about the incorrect use of race as a biological construct and its negative impact on health equity.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Elisabet Van Loon, Wanqiu Zhang, Maarten Coemans, Maarten De Vos, Marie-Paule Emonds, Irina Scheffner, Wilfried Gwinner, Dirk Kuypers, Aleksandar Senev, Claire Tinel, Amaryllis H. Van Craenenbroeck, Bart De Moor, Maarten Naesens
Summary: A deep learning model was developed and validated to predict the patient-specific expected reference range of eGFR after kidney transplant, showing promising results in accurately forecasting individual trajectories within the first 3 months post-transplant.
Article
Medicine, General & Internal
Ha-Jin Lim, Seung-Yeob Lee, Hyun-Jung Choi
Summary: The accuracy of ABL90 FLEX PLUS in measuring creatinine and blood urea nitrogen was evaluated, and suitable candidate specimens were identified. The results showed that ABL90 FLEX PLUS had mean differences of -0.10 and -3.51 mg/dL for creatinine and blood urea nitrogen, respectively, compared to other analyzers. Serum was found to be suitable for creatinine testing using ABL90 FLEX PLUS, while citrated whole-blood did not meet the acceptance criteria.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Minnie N. Dasgupta, Maria E. Montez-Rath, Seth A. Hollander, Scott M. Sutherland
Summary: This study found that AKI is common in children undergoing cardiac transplantation, particularly within 24 hours post-surgery, with 75% of patients developing AKI and 45% developing severe AKI. kGFR is moderately associated with identifying AKI risk, presenting a potential novel risk stratification technique.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Ying Tang, Ling Hou, Tingting Sun, Shanping Li, Junli Cheng, Dan Xue, Xiuli Wang, Yue Du
Summary: Equations for estimating glomerular filtration rate (GFR) in Chinese children with chronic kidney disease (CKD) were developed based on serum creatinine, blood urea nitrogen (BUN), and cystatin C. These equations were found to be more accurate than commonly used equations in this population.
PEDIATRIC NEPHROLOGY
(2023)
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.