Review
Nutrition & Dietetics
Jing Cong, Ping Zhou, Ruiyan Zhang
Summary: Intestinal microbiota plays a crucial role in human physiology by producing metabolites, such as short chain fatty acids (SCFAs), which regulate colon physiology and influence the intestinal environment. Recent research has shown that SCFAs not only affect the gut's signal transduction pathway but also reach tissues and organs outside of the gut through the bloodstream. The level of SCFAs is increasingly recognized as important for maintaining health and preventing disease. This review provides a systematic theoretical basis for studying the mechanisms and precise intake levels of SCFAs to promote human health.
Article
Biochemistry & Molecular Biology
Qi Hui Sam, Hua Ling, Wen Shan Yew, Zhaohong Tan, Sharada Ravikumar, Matthew Wook Chang, Louis Yi Ann Chai
Summary: Short chain fatty acids (SCFA) and medium chain fatty acids (MCFA) have divergent immunomodulatory propensities, with SCFA down-attenuating pro-inflammatory response through the TLR4 pathway, while MCFA augmenting inflammation through TLR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Karolina Szacherska, Krzysztof Moraczewski, Sylwester Czaplicki, Piotr Oleskowicz-Popiel, Justyna Mozejko-Ciesielska
Summary: This study evaluated the use of short- and medium-chain fatty acids (SMCFAs) derived from acid whey fermentation for polyhydroxyalkanoate (PHA) production. Pseudomonas sp. GL06 showed the highest tolerance to SMCFAs and produced PHAs with the highest productivity. Further research revealed that PHA monomeric composition varied with bacterial strain and growth medium. The copolymer made of 3-hydroxybutyric, -hexanoic, -octanoic, -decanoic, and -dodecanoic exhibited promising properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Azemina Bajramova, Peter Spegel
Summary: This study compares the nutritional value of the fatty acid profiles of superfruits (goji berry, white mulberry, and cranberry) and common fruits (banana, apple, and strawberry). The findings suggest that cranberries and apples have the most beneficial lipid profiles, while superfruits do not show a common and beneficial lipid profile.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Agriculture, Dairy & Animal Science
Cristina Higueras, Ana I. Rey, Rosa Escudero, David Diaz-Reganon, Fernando Rodriguez-Franco, Mercedes Garcia-Sancho, Beatriz Agulla, Angel Sainz
Summary: Food-responsive enteropathy (FRE) is the most common diagnosis for dogs with chronic enteropathy, and there is currently no test that can replace treatment trials. This study found changes in the fatty acid profiles of plasma and feces in sick dogs, and high correlations between certain compounds and existing indices. Dogs with FRE had different fatty acid profiles compared to healthy dogs, both in plasma and feces. These findings highlight the importance of fatty acids, particularly fecal parameters, in diagnosing and evaluating the inflammatory status of dogs.
Article
Engineering, Chemical
Li-Jen Lin, Mukesh Saini, Chung-Jen Chiang, Yun-Peng Chao
Summary: In this study, a whole cell biocatalysis system was used to produce short-chain alcohols from fatty acids. Escherichia coli strain was reprogrammed to improve biocatalytic activity, resulting in successful production of 1-propanol and n-pentanol.
Article
Nutrition & Dietetics
Iris Trefflich, Stefan Dietrich, Annett Braune, Klaus Abraham, Cornelia Weikert
Summary: This study compared concentrations of SCFA, BCFA, ammonia, and fecal pH between vegans and omnivores, finding no significant differences in SCFA and BCFA concentrations but lower fecal pH and ammonia concentration in vegans. The results suggest that bacterial functionality may be adapted to varying nutrient availability in these diets.
Article
Engineering, Environmental
Hyeonho Lee, Sung-Ju Im, Chang-min Kim, Am Jang
Summary: The transport behavior difference between virgin and supported liquid membrane contactors and the selectivity of medium-chain fatty acids in the supported liquid membrane contactors were studied. The results showed that the transport flux and selectivity of medium-chain fatty acids were significantly improved in the supported liquid PVDF membrane.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Silke Matysik, Sabrina Krautbauer, Gerhard Liebisch, Hans-Frieder Schott, Louise Kjolbaek, Arne Astrup, Francois Blachier, Martin Beaumont, Max Nieuwdorp, Annick Hartstra, Simone Rampelli, Uberto Pagotto, Patricia Iozzo
Summary: This study quantified the concentrations of faecal sterol species, bile acids, and short-chain fatty acids in 165 study participants. Participants were classified as low or high converters based on their coprostanol/cholesterol ratio, with low converters excreting more straight-chain fatty acids and bile acids. Concentration ranges of 16 faecal metabolites were provided as reference values, showing significant differences in faecal metabolites between high and low sterol converter groups.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carmen Gonzalez-Bosch, Emily Boorman, Patricia A. Zunszain, Giovanni E. Mann
Summary: SCFAs, short-chain fatty acids derived from colonic bacteria and diet, have beneficial effects on human health related to their metabolic and signaling properties. They play a role in protecting against oxidative and mitochondrial stress, regulating metabolic pathways, and inducing signaling pathways such as Nrf2 to maintain redox homeostasis. Additionally, SCFAs may have potential as nutritional and therapeutic agents in various diseases including diabetes, neuropathologies, and cancer.
Article
Nutrition & Dietetics
Andras Gregor, Sandra Auernigg-Haselmaier, Slave Trajanoski, Juergen Koenig, Kalina Duszka
Summary: The study reveals that diets and nutrition factors can affect the production of fatty acids, including the impact of caloric restriction, high fiber diet, and rectal infusion of caprylate. Caprylate may have an influence on metabolism and inflammatory parameters.
Review
Cell Biology
Dan Zhang, Yong-Ping Jian, Yu-Ning Zhang, Yao Li, Li-Ting Gu, Hui-Hui Sun, Ming-Di Liu, Hong-Lan Zhou, Yi-Shu Wang, Zhi-Xiang Xu
Summary: Short-chain fatty acids (SCFAs) are metabolites produced by bacterial fermentation of dietary fiber in the gut. They are absorbed by substrate transporters and play important roles in cellular metabolism. SCFAs are vital fuels for intestinal epithelial cells (IECs) and influence molecular processes such as blood glucose regulation and IEC function. They also affect intestinal motility, barrier function, and host metabolism, and play regulatory roles in local and peripheral metabolism. Major SCFAs like acetate, propionate, and butyrate are involved in immunity, apoptosis, inflammation, and lipid metabolism. This review highlights the diverse functional roles of SCFAs and their impact on intestines, metabolism, and diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Geriatrics & Gerontology
Rei Otsuka, Shu Zhang, Kanae Furuya, Chikako Tange, Giovanni Sala, Fujiko Ando, Hiroshi Shimokata, Yukiko Nishita, Hidenori Arai
Summary: This study aimed to investigate the association between dietary intake of short-chain fatty acids (SCFAs) and the development of low muscle strength in older adults. The findings from the longitudinal study of 823 participants showed that higher intake of SCFAs was associated with a reduced risk of muscle strength decline in older community dwellers.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Food Science & Technology
Muthu Thiruvengadam, Umadevi Subramanian, Baskar Venkidasamy, Prabhu Thirupathi, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Ill-Min Chung, Kannan R. R. Rengasamy
Summary: Understanding the gut microbiota has become crucial in maintaining human body's homeostasis and preventing disease development. Short-chain fatty acids, produced by gut microbiota fermentation of dietary fiber, play a significant role in modulating the tumor environment and binding to carcinogens for elimination. The gut microbiota may offer new approaches for cancer therapy in the future.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Abdur Rauf, Anees Ahmed Khalil, Ubaid-Ur Rahman, Ahood Khalid, Saima Naz, Mohammad Ali Shariati, Maksim Rebezov, Ewaldo Zavala Urtecho, Ricardo Diego Duarte Galhardo de Albuquerque, Sirajudheen Anwar, Abdulwahab Alamri, Ramesh Kumar Saini, Kannan R. R. Rengasamy
Summary: The gut microbiota plays an important role in regulating metabolic functionalities in humans, with SCFAs receiving particular attention for their pharmacological and physiological characteristics. Research on the molecular mechanisms underlying the interaction between SCFAs, diet, gut microbiota, and host energy metabolism is still needed. Recent biotechnological advances have shown the potential of using SCFAs as important metabolites to treat diseases and maintain colon health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tamaki Matsunami, Kazuo Hino, Rie Dosho, Sho Miyatake, Goro Ebisu, Ryohei Kuwatsuru
JAPANESE JOURNAL OF RADIOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tamaki Matsunami, Kazuo Hino, Rie Dosho, Sho Miyatake, Goro Ebisu, Ryohei Kuwatsuru
JAPANESE JOURNAL OF RADIOLOGY
(2017)
Article
Toxicology
Koichi Tomoda, Kaoru Kubo, Kazuo Hino, Yasunori Kondoh, Yasue Nishii, Noriko Koyama, Yoshifumi Yamamoto, Masanori Yoshikawa, Hiroshi Kimura
JOURNAL OF TOXICOLOGICAL SCIENCES
(2014)
Article
Nutrition & Dietetics
Kazuo Hino, Sho Miyatake, Fumiyo Yamada, Naoyuki Endo, Ryosuke Akiyama, Goro Ebisu
Article
Nutrition & Dietetics
Sho Miyatake, Kazuo Hino, Yuko Natsui, Goro Ebisu, Satoshi Fujita
Article
Biochemistry & Molecular Biology
Sho Miyatake, Kazuo Hino, Goro Ebisu, Satoshi Fujita
Summary: Oral administration of L-citrulline may increase the delivery of substances to skeletal muscles by increasing NO production in both normal and vascular endothelial dysfunction models.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Neurosciences
K Hino, M Nishikawa, E Sato, M Inoue
Article
Rheumatology
K Shiozawa, K Hino, S Shiozawa
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.
