Gut Microbiota and the Neuroendocrine System

The microbiota influences cell death and microglial colonization in the perinatal mouse brain

(2018) Alexandra Castillo-Ruiz et al.   BRAIN BEHAVIOR AND IMMUNITY

Clinical relevance of metronidazole and peripheral neuropathy: a systematic review of the literature

(2018) Tiffany A. Goolsby et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review

(2018) Mario F. Juruena et al.   JOURNAL OF AFFECTIVE DISORDERS

The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

(2017) Sohn Kim et al.   IMMUNOLOGICAL REVIEWS

Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder

(2017) Kelly Doolin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4

(2017) Kazuaki Nakata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bifidobacterium pseudocatenulatum CECT 7765 Ameliorates Neuroendocrine Alterations Associated with an Exaggerated Stress Response and Anhedonia in Obese Mice

(2017) Ana Agusti et al.   MOLECULAR NEUROBIOLOGY

NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience

(2017) A Singh-Taylor et al.   MOLECULAR PSYCHIATRY

L. fermentum CECT 5716 prevents stress-induced intestinal barrier dysfunction in newborn rats

(2017) T. Vanhaecke et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

(2017) S.M. O’Mahony et al.   NEUROSCIENCE

Anxiogenic effects of a Lactobacillus, inulin and the synbiotic on healthy juvenile rats

(2017) Camila Barrera-Bugueño et al.   NEUROSCIENCE

Probiotic treatment reduces depressive-like behaviour in rats independently of diet

(2017) Anders Abildgaard et al.   PSYCHONEUROENDOCRINOLOGY

Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice

(2017) Giada De Palma et al.   Science Translational Medicine

Modulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure

(2017) Miranda van Bodegom et al.   Frontiers in Cellular Neuroscience

From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder

(2017) Bangshan Liu et al.   Frontiers in Cellular Neuroscience

Microbial colonization is required for normal neurobehavioral development in zebrafish

(2017) Drake Phelps et al.   Scientific Reports

Microbial regulation of microRNA expression in the amygdala and prefrontal cortex

(2017) Alan E. Hoban et al.   Microbiome

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

(2017) Lucy Brooks et al.   Molecular Metabolism

Early life peripheral lipopolysaccharide challenge reprograms catecholaminergic neurons

(2017) Lin Kooi Ong et al.   Scientific Reports

Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

(2016) Esther E. Fröhlich et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth

(2016) Jonathan Breton et al.   Cell Metabolism

May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry

(2016) Eoin Sherwin et al.   CNS DRUGS

Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus

(2016) Pauline Luczynski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Early-life antibiotic treatment enhances the pathogenicity of CD4 + T cells during intestinal inflammation

(2016) Sebastian Scheer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

(2016) John R. Kelly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior

(2016) T Arentsen et al.   MOLECULAR PSYCHIATRY

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat

(2016) A.E. Hoban et al.   NEUROSCIENCE

The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression

(2016) Elizabeth J. Videlock et al.   PSYCHONEUROENDOCRINOLOGY

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities

(2016) Anastasiya Slyepchenko et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling

(2016) Roberto Mazzoli et al.   Frontiers in Microbiology

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

(2016) A P Allen et al.   Translational Psychiatry

The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour

(2015) A. Farzi et al.   Acta Physiologica

Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?

(2015) Mirjana Rajilić-Stojanović et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers

(2015) Aitak Farzi et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

(2015) Lieve Desbonnet et al.   BRAIN BEHAVIOR AND IMMUNITY

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Microbes & neurodevelopment – Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala

(2015) Roman M. Stilling et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia function during brain development: New insights from animal models

(2015) Parizad M. Bilimoria et al.   BRAIN RESEARCH

Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication

(2015) Sahar El Aidy et al.   CLINICAL THERAPEUTICS

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia

(2015) Samuel M. Cohen et al.   SCHIZOPHRENIA RESEARCH

Microbiota and host determinants of behavioural phenotype in maternally separated mice

(2015) G. De Palma et al.   Nature Communications

Lactobacillus fermentumNS9 restores the antibiotic induced physiological and psychological abnormalities in rats

(2015) T. Wang et al.   Beneficial Microbes

Stress Induces Endotoxemia and Low-Grade Inflammation by Increasing Barrier Permeability

(2015) Karin de Punder et al.   Frontiers in Immunology

Prenatal Stress Enhances Excitatory Synaptic Transmission and Impairs Long-Term Potentiation in the Frontal Cortex of Adult Offspring Rats

(2015) Joanna Sowa et al.   PLoS One

N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota

(2015) Matteo M. Pusceddu et al.   PLoS One

Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice

(2014) Carli J. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

Bifidobacteriaexert strain-specific effects on stress-related behavior and physiology in BALB/c mice

(2014) H. M. Savignac et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Correlation between the human fecal microbiota and depression

(2014) A. Naseribafrouei et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Possible additional antidepressant-like mechanism of sodium butyrate: Targeting the hippocampus

(2014) Arum Han et al.   NEUROPHARMACOLOGY

Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats

(2014) S.M. O’Mahony et al.   NEUROSCIENCE

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats

(2014) Michèle Crumeyrolle-Arias et al.   PSYCHONEUROENDOCRINOLOGY

Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

(2014) Kristin Schmidt et al.   PSYCHOPHARMACOLOGY

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders

(2014) N Tennoune et al.   Translational Psychiatry

Production of gaba (γ - aminobutyric acid) by microorganisms: a review

(2013) Radhika Dhakal et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

The Gut Microbiota Reduces Leptin Sensitivity and the Expression of the Obesity-Suppressing Neuropeptides Proglucagon (Gcg) and Brain-Derived Neurotrophic Factor (Bdnf) in the Central Nervous System

(2013) Erik Schéle et al.   ENDOCRINOLOGY

Vitamin A regulates hypothalamic–pituitary–adrenal axis status in LOU/C rats

(2013) Nathalie Marissal-Arvy et al.   JOURNAL OF ENDOCRINOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Stress and antibiotics alter luminal and wall-adhered microbiota and enhance the local expression of visceral sensory-related systems in mice

(2013) M. Aguilera et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods

(2013) R. Nishino et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice

(2013) A. Ait-Belgnaoui et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome

(2012) Michael Camilleri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

(2012) Yasunari Asano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

(2012) Akila De Silva et al.   Gut and Liver

Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic–pituitary–adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life

(2012) Hui-Feng Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis

(2012) Peter Holzer et al.   NEUROPEPTIDES

Increased Oral Detection, but Decreased Intestinal Signaling for Fats in Mice Lacking Gut Microbiota

(2012) Frank A. Duca et al.   PLoS One

Effect of Maternal Probiotic Intervention on HPA Axis, Immunity and Gut Microbiota in a Rat Model of Irritable Bowel Syndrome

(2012) Javad Barouei et al.   PLoS One

Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology

(2012) Timothy G. Dinan et al.   PSYCHONEUROENDOCRINOLOGY

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

(2012) Afifa Ait-Belgnaoui et al.   PSYCHONEUROENDOCRINOLOGY

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear

(2011) Theodore R. Sadler et al.   BRAIN RESEARCH

Association Between Early Adverse Life Events and Irritable Bowel Syndrome

(2011) Kara Bradford et al.   Clinical Gastroenterology and Hepatology

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression

(2011) Iciar Gárate et al.   Journal of Neuroinflammation

Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment

(2011) S.B. Sartori et al.   NEUROPHARMACOLOGY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

(2010) Michaël Messaoudi et al.   BRITISH JOURNAL OF NUTRITION

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

(2010) R. Nau et al.   CLINICAL MICROBIOLOGY REVIEWS

Plasticity of neuroendocrine systems

(2010) Vincent Prevot   EUROPEAN JOURNAL OF NEUROSCIENCE

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Early Life Activation of Toll-Like Receptor 4 Reprograms Neural Anti-Inflammatory Pathways

(2010) A. Mouihate et al.   JOURNAL OF NEUROSCIENCE

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

(2010) L. Desbonnet et al.   NEUROSCIENCE

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1

(2009) Elizabeth A. Shirtcliff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

(2008) Makoto Usami et al.   NUTRITION RESEARCH

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE