Article
Oncology
Georgios Batsios, Celine Taglang, Meryssa Tran, Nicholas Stevers, Carter Barger, Anne Marie Gillespie, Sabrina M. Ronen, Joseph F. Costello, Pavithra Viswanath
Summary: TERT expression is associated with elevated NADH in multiple cancers, which can be imaged in vivo by 2H-MRS. The production of lactate from [U-2H]-pyruvate can be used as an early indicator of treatment response, providing a novel tool for the assessment of tumor burden and treatment response.
CLINICAL CANCER RESEARCH
(2022)
Article
Environmental Sciences
Chung-Yao Hsu, Yao-Chung Chuang, Fang-Chia Chang, Hung-Yi Chuang, Terry Ting-Yu Chiou, Chien-Te Lee
Summary: Chronic lead exposure disrupts the sleep-wake cycle in rats, particularly disrupting sleep homeostasis. This disturbance is associated with toxic effects on clock gene expression in the hypothalamus.
Article
Plant Sciences
James Ronald, Chen Su, Lei Wang, Seth J. Davis
Summary: This study reveals that the cellular and sub-nuclear localization of the protein ELF3 in Arabidopsis is responsive to red and blue light, with these wavelengths having competitive effects on its localization. The researchers also found that at least two red light pathways influence the cellular localization of ELF3. Furthermore, changes in the cellular localization of ELF3 are associated with the repression of target-gene expression in the evening complex.
Article
Pharmacology & Pharmacy
Agustin. J. Montivero, Marisa. S. Ghersi, M. Jazmin Silvero C, Emilce Artur de la Villarmois, Johanna Catalan-Figueroa, Macarena Herrera, Maria Cecilia Becerra, Claudia. B. Herenu, Mariela. F. Perez
Summary: Traumatic Brain Injury (TBI) causes neuroinflammation and oxidative stress, leading to neurological deficits and decreased survival rates. While traditional anti-inflammatory treatments have shown limited efficacy, early IGF-1 gene therapy may be a promising approach to reduce cognitive deficits associated with TBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Bo Lv, Juan Wang, Yuan He, Zhi Zeng, Yun-e Tang, Na Li, Li-jun Chen, Zhi Wang, Qi-sheng Song
Summary: This study investigated neural alterations in the spider Pardosa pseudoannulata exposed to different durations of cadmium pressure. Results showed that cadmium stress reduced foraging ability in spiders and affected the expression of neurotransmitter receptors and ion transport proteins. Additionally, long-term cadmium exposure may further regulate energy metabolism pathways in spiders, providing comprehensive insights into the molecular response of spiders to cadmium exposure.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Pia Laitinen, Mari-Anna Vaananen, Ida-Liisa Kolari, Petri Makinen, Minna U. Kaikkonen, Marc S. Weinberg, Kevin Morris, Paula Korhonen, Tarja Malm, Seppo Yla-Herttuala, Thomas C. Roberts, Mikko P. Turunen, Tiia A. Turunen
Summary: This study reveals the involvement of nuclear miR-466c in the regulation of Vegfa gene expression in mouse endothelial cells under hypoxic conditions. The research demonstrates that miR-466c directly targets the promoter region to modulate Vegfa transcription in the nucleus, expanding our understanding of miRNA functionality.
Article
Biochemistry & Molecular Biology
Jorge Urresti, Pan Zhang, Patricia Moran-Losada, Nam-Kyung Yu, Priscilla D. Negraes, Cleber A. Trujillo, Danny Antaki, Megha Amar, Kevin Chau, Akula Bala Pramod, Jolene Diedrich, Leon Tejwani, Sarah Romero, Jonathan Sebat, John R. Yates, Alysson R. Muotri, Lilia M. Iakoucheva
Summary: Reciprocal deletion and duplication of the 16p11.2 region are associated with autism spectrum disorders and impact neurodevelopmental processes. CNV dosage affects neuronal maturation, proliferation, and the ratio of neurons to neural progenitors in organoids. Dysregulation of multiple pathways, including neuron migration and actin cytoskeleton, is observed in 16p11.2 CNV, with increased levels of active RhoA implicated in migration deficits.
MOLECULAR PSYCHIATRY
(2021)
Article
Environmental Sciences
Zuo Wang, Haiyu Zhao, Yanyi Xu, Jianing Zhao, Zan Song, Yi Bi, Yang Li, Xianyong Lan, Chuanying Pan, Nicholas S. Foulkes, Shengxiang Zhang
Summary: Lead-induced neurotoxicity has been extensively studied, but the connection between early-life lead exposure and abnormal neurobehavior in juveniles and adults is still unclear. Using a zebrafish model, this study found that early-life exposure to lead caused neurologic damage and defective neurobehavior, with affected vitality and social behavior in juvenile and adult fish. The modulation of key genes and neuronal density changes may contribute to the observed neurobehavioral disorders.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Urology & Nephrology
Masahiro Okabe, Kentaro Koike, Izumi Yamamoto, Nobuo Tsuboi, Taiji Matsusaka, Takashi Yokoo
Summary: This study found that EGR1 is a promising marker for identifying early podocyte injury in human glomerular diseases.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Cell Biology
Rohan Kulkarni
Summary: Aging is associated with increased risk of various hematological disorders and myeloproliferative disorders. Hematopoietic stem cells (HSCs) play a crucial role in regulating the production of blood cells throughout life. Early growth response factor 1 (EGR1) is a key transcription factor controlling HSC proliferation and localization in the bone marrow. Downregulation of EGR1 activates HSCs for proliferation and differentiation, while increased expression of EGR1 is implicated in immune aging of HSCs and associated with hematological malignancies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Yanjun Wu, Hongmei Huang, Jiayun Wu, Yiru Qin, Na Zhao, Baowei Chen, Qiying Nong, Yongshun Huang, Ligang Hu
Summary: This study investigates the mechanism of lead-induced myocardial injury and finds that neutrophil degranulation plays a significant role in this process. The findings suggest that lead exposure can initiate early myocardial injury by promoting neutrophil degranulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Oncology
Gabriel A. Kwong, Sharmistha Ghosh, Lena Gamboa, Christos Patriotis, Sudhir Srivastava, Sangeeta N. Bhatia
Summary: The article discusses the rationale and design of using synthetic biomarkers to enhance the sensitivity and specificity of detecting early-stage cancers, as well as highlighting the challenges in preclinical development and clinical translation.
NATURE REVIEWS CANCER
(2021)
Article
Multidisciplinary Sciences
Yana Irawati, Haryoto Kusnoputranto, Umar Fahmi Achmadi, Ahmad Safrudin, Alfred Sitorus, Rifqi Risandi, Suradi Wangsamuda, Puji Budi Setia Asih, Din Syafruddin
Summary: The present study investigated the blood lead levels and evidence of lead toxicity among children living in an ULAB recycling site in Bogor Regency, Indonesia. The results showed that a majority of the children had elevated blood lead levels, as well as a significant proportion with underweight, stunting, and anemia. The study also revealed associations between blood lead levels and BMI, anemia, and basophilic stippling.
Article
Infectious Diseases
Shang Lu, Dan Li, Leilei Wang, Yingmin Bi, Minghua Wang, Fan Yang
Summary: This study identified the mcr-1 gene in 15 clinical isolates of Enterobacteriaceae, with promoter variations associated with expression of the mcr-1 gene and ultimately the levels of colistin resistance.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Pathology
Abbe R. Clark, Jamie Marshall, Yiming Zhou, Monica S. Montesinos, Haiqi Chen, Lan Nguyen, Fei Chen, Anna Greka
Summary: Communication among podocytes, endothelial cells, and mesangial cells is crucial for the health of the kidney filtration barrier. Disruption of these interactions contributes to disease progression in chronic kidney diseases (CKDs). A study using single-cell RNA sequencing revealed the earliest transcriptional effects of podocyte injury on cell-cell interactions within the kidney filter, highlighting potential therapeutic targets for CKDs.
AMERICAN JOURNAL OF PATHOLOGY
(2022)