标题
Orthosteric and allosteric action of the C5a receptor antagonists
作者
关键词
-
出版物
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 25, Issue 6, Pages 472-481
出版商
Springer Nature
发表日期
2018-05-29
DOI
10.1038/s41594-018-0067-z
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727
- (2018) Nathan Robertson et al. NATURE
- Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis
- (2017) David R.W. Jayne et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease
- (2017) Manoj K. Pandey et al. NATURE
- Structural basis for selectivity and diversity in angiotensin II receptors
- (2017) Haitao Zhang et al. NATURE
- Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
- (2017) Jun Lu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
- Structural Basis for Apelin Control of the Human Apelin Receptor
- (2017) Yingli Ma et al. STRUCTURE
- Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
- (2017) Jun Lu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Activation mechanism of endothelin ETB receptor by endothelin-1
- (2016) Wataru Shihoya et al. NATURE
- C5a and pain development: An old molecule, a new target
- (2016) Andreza U. Quadros et al. PHARMACOLOGICAL RESEARCH
- Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study
- (2016) Pirow Bekker et al. PLoS One
- Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer’s disease
- (2015) Christine Landlinger et al. Journal of Neuroinflammation
- Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry
- (2015) Nguyen Minh Duc et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Two disparate ligand-binding sites in the human P2Y1 receptor
- (2015) Dandan Zhang et al. NATURE
- Structural insights into µ-opioid receptor activation
- (2015) Weijiao Huang et al. NATURE
- Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine
- (2015) L. Qin et al. SCIENCE
- Complement C5a Receptor Facilitates Cancer Metastasis by Altering T-Cell Responses in the Metastatic Niche
- (2014) S. K. Vadrevu et al. CANCER RESEARCH
- Immunological effects and therapeutic role of C5a in cancer
- (2014) Victoria R Darling et al. Expert Review of Clinical Immunology
- Molecular control of δ-opioid receptor signalling
- (2014) Gustavo Fenalti et al. NATURE
- Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief
- (2014) Alessio Moriconi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of an irreversible HCV NS5B polymerase inhibitor
- (2013) Qingbei Zeng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88)
- (2013) H. Nitta et al. CLINICAL CANCER RESEARCH
- C5L2: a controversial receptor of complement anaphylatoxin, C5a
- (2012) Rui Li et al. FASEB JOURNAL
- Structure of the agonist-bound neurotensin receptor
- (2012) Jim F. White et al. NATURE
- High-resolution crystal structure of human protease-activated receptor 1
- (2012) Cheng Zhang et al. NATURE
- Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
- (2012) W. Liu et al. SCIENCE
- Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors
- (2012) Eugene Chun et al. STRUCTURE
- Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease
- (2011) Maria I Fonseca et al. Journal of Neuroinflammation
- Inhibiting the C5–C5a receptor axis
- (2011) Trent M. Woodruff et al. MOLECULAR IMMUNOLOGY
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Rapid Context-Dependent Ligand Desolvation in Molecular Docking
- (2010) Michael M. Mysinger et al. Journal of Chemical Information and Modeling
- Pivotal Advance: Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution
- (2010) Nan Jia et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
- (2010) B. Wu et al. SCIENCE
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Recent developments in low molecular weight complement inhibitors
- (2009) Hongchang Qu et al. MOLECULAR IMMUNOLOGY
- The role of the anaphylatoxins in health and disease
- (2009) Andreas Klos et al. MOLECULAR IMMUNOLOGY
- Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors
- (2009) T. E. Angel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystallizing Membrane Proteins for Structure Determination: Use of Lipidic Mesophases
- (2008) Martin Caffrey Annual Review of Biophysics
- Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor†
- (2008) Gregory V. Nikiforovich et al. BIOCHEMISTRY
- Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor
- (2008) Elena S. Suvorova et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches
- (2008) Lars Konermann et al. JOURNAL OF MASS SPECTROMETRY
- Identification and Characterization of NDT 9513727 [N,N-bis(1,3-Benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a Novel, Orally Bioavailable C5a Receptor Inverse Agonist
- (2008) R. M. Brodbeck et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Modulation of the antitumor immune response by complement
- (2008) Maciej M Markiewski et al. NATURE IMMUNOLOGY
- Formyl peptide receptor-mediated ERK1/2 activation occurs through Gi and is not dependent on β-arrestin1/2
- (2007) Jeannie M. Gripentrog et al. CELLULAR SIGNALLING
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