Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor

(2011) R Bertini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

The complement component C5a receptor mediates pain and inflammation in a postsurgical pain model

(2011) De-Yong Liang et al.   PAIN

Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: Molecular modeling study

(2011) Gregory V. Nikiforovich et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A Medicinal Chemist’s Guide to Molecular Interactions

(2010) Caterina Bissantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

(2010) Ralf Baron et al.   LANCET NEUROLOGY

The minor binding pocket: a major player in 7TM receptor activation

(2010) Mette M. Rosenkilde et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Impact of opioid rescue medication for breakthrough pain on the efficacy and tolerability of long-acting opioids in patients with chronic non-malignant pain

(2009) J. Devulder et al.   BRITISH JOURNAL OF ANAESTHESIA

Nociceptive sensitization by complement C5a and C3a in mouse

(2009) Jun Ho Jang et al.   PAIN

Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor†

(2008) Gregory V. Nikiforovich et al.   BIOCHEMISTRY

Chemokine receptor antagonists: overcoming developmental hurdles

(2008) Richard Horuk   NATURE REVIEWS DRUG DISCOVERY

Allosteric inhibitors of chemoattractant receptors: opportunities and pitfalls

(2008) M ALLEGRETTI et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain

(2007) E Ting et al.   BRITISH JOURNAL OF PHARMACOLOGY

Complement activation in the peripheral nervous system following the spinal nerve ligation model of neuropathic pain☆

(2007) Margaret E. Levin et al.   PAIN