Neuroscience of apathy and anhedonia: a transdiagnostic approach

Historical crossroads in the conceptual delineation of apathy in Parkinson’s disease

(2018) Stéphane Prange et al.   BRAIN

Distinct effects of apathy and dopamine on effort-based decision-making in Parkinson’s disease

(2018) Campbell Le Heron et al.   BRAIN

Striatal dopamine D2/3 receptor-mediated neurotransmission in major depression: Implications for anhedonia, anxiety and treatment response

(2017) Marta Peciña et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Blunted neural response to anticipation, effort and consummation of reward and aversion in adolescents with depression symptomatology

(2017) Ewelina Rzepa et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders

(2017) M Kokkinou et al.   MOLECULAR PSYCHIATRY

The anatomy of apathy: A neurocognitive framework for amotivated behaviour

(2017) C. Le Heron et al.   NEUROPSYCHOLOGIA

The “highs and lows” of the human brain on dopaminergics: Evidence from neuropharmacology

(2017) Daniel Martins et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Investigating consummatory and anticipatory pleasure across motivation deficits in schizophrenia and healthy controls

(2017) Susana Da Silva et al.   PSYCHIATRY RESEARCH

Individual negative symptoms and domains – Relevance for assessment, pathomechanisms and treatment

(2017) Stefan Kaiser et al.   SCHIZOPHRENIA RESEARCH

Apathy and Executive Function in Healthy Elderly—Resting State fMRI Study

(2017) Toshikazu Kawagoe et al.   Frontiers in Aging Neuroscience

Association of Neural and Emotional Impacts of Reward Prediction Errors With Major Depression

(2017) Robb B. Rutledge et al.   JAMA Psychiatry

The brief negative symptom scale: validation of the German translation and convergent validity with self-rated anhedonia and observer-rated apathy

(2016) Martin Bischof et al.   BMC Psychiatry

The prominent role of serotonergic degeneration in apathy, anxiety and depression inde novoParkinson’s disease

(2016) Audrey Maillet et al.   BRAIN

Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson’s disease

(2016) Kinan Muhammed et al.   BRAIN

Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology

(2016) John D. Salamone et al.   BRAIN

Human ventromedial prefrontal lesions alter incentivisation by reward

(2016) Sanjay G. Manohar et al.   CORTEX

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

(2016) Qing-Fei Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

A17 HD brain-train: neuroplasticity as a target to improve function in huntington’s disease

(2016) Marina Papoutsi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Computational Dissection of Dopamine Motor and Motivational Functions in Humans

(2016) Raphaël Le Bouc et al.   JOURNAL OF NEUROSCIENCE

Dopamine Manipulation Affects Response Vigor Independently of Opportunity Cost

(2016) A. Zenon et al.   JOURNAL OF NEUROSCIENCE

Neural Signatures of Value Comparison in Human Cingulate Cortex during Decisions Requiring an Effort-Reward Trade-off

(2016) M. C. Klein-Flugge et al.   JOURNAL OF NEUROSCIENCE

Cost and Outcome of Behavioural Activation versus Cognitive Behavioural Therapy for Depression (COBRA): a randomised, controlled, non-inferiority trial

(2016) David A Richards et al.   LANCET

Surprise! Dopamine signals mix action, value and error

(2016) Anne G E Collins et al.   NATURE NEUROSCIENCE

The Iowa Gambling Task in Parkinson's disease: A meta-analysis on effects of disease and medication

(2016) Ricarda Evens et al.   NEUROPSYCHOLOGIA

Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

(2016) Jennifer C Felger et al.   NEUROPSYCHOPHARMACOLOGY

Assessing anhedonia in depression: Potentials and pitfalls

(2016) Sakina J. Rizvi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The specificity of Pavlovian regulation is associated with recovery from depression

(2016) Q. J. M. Huys et al.   PSYCHOLOGICAL MEDICINE

A Psychometric Comparison of the Clinical Assessment Interview for Negative Symptoms and the Brief Negative Symptom Scale

(2016) Gregory P. Strauss et al.   SCHIZOPHRENIA BULLETIN

A specific role for serotonin in overcoming effort cost

(2016) Florent Meyniel et al.   eLife

Apathy in Late-Life Depression: Common, Persistent, and Disabling

(2015) Genevieve S. Yuen et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

The Brain’s Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample

(2015) Argyris Stringaris et al.   AMERICAN JOURNAL OF PSYCHIATRY

Depression: A Decision-Theoretic Analysis

(2015) Quentin J.M. Huys et al.   Annual Review of Neuroscience

Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis

(2015) Bei Zhang et al.   Brain Imaging and Behavior

Dopamine enhances willingness to exert effort for reward in Parkinson's disease

(2015) Trevor T.-J. Chong et al.   CORTEX

Activation of Dorsal Raphe Serotonergic Neurons Promotes Waiting but Is Not Reinforcing

(2015) Madalena S. Fonseca et al.   CURRENT BIOLOGY

Disrupting the Supplementary Motor Area Makes Physical Effort Appear Less Effortful

(2015) A. Zenon et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic Modulation of Decision Making and Subjective Well-Being

(2015) R. B. Rutledge et al.   JOURNAL OF NEUROSCIENCE

Apathy in Parkinson's disease: A systematic review and meta-analysis

(2015) Melina G.H.E. den Brok et al.   MOVEMENT DISORDERS

Action initiation shapes mesolimbic dopamine encoding of future rewards

(2015) Emilie C J Syed et al.   NATURE NEUROSCIENCE

Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors

(2015) Chun Yun Chang et al.   NATURE NEUROSCIENCE

Mesolimbic dopamine signals the value of work

(2015) Arif A Hamid et al.   NATURE NEUROSCIENCE

Striatal D1 and D2 signaling differentially predict learning from positive and negative outcomes

(2015) Sylvia M.L. Cox et al.   NEUROIMAGE

Pleasure Systems in the Brain

(2015) Kent C. Berridge et al.   NEURON

Development and validation of the Dimensional Anhedonia Rating Scale (DARS) in a community sample and individuals with major depression

(2015) Sakina J. Rizvi et al.   PSYCHIATRY RESEARCH

The effects of pharmacological modulation of the serotonin 2C receptor on goal-directed behavior in mice

(2015) Matthew R. Bailey et al.   PSYCHOPHARMACOLOGY

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

(2015) E. A. Ferenczi et al.   SCIENCE

The associations between fatigue, apathy, and depression in Parkinson's disease

(2014) M. Skorvanek et al.   ACTA NEUROLOGICA SCANDINAVICA

Serotonergic modulation of reward and punishment: Evidence from pharmacological fMRI studies

(2014) Julian Macoveanu   BRAIN RESEARCH

Neural response to reward anticipation in those with depression with and without panic disorder

(2014) Stephanie M. Gorka et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuropsychiatric symptoms in a European Huntington's disease cohort (REGISTRY)

(2014) Erik van Duijn et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Learning To Minimize Efforts versus Maximizing Rewards: Computational Principles and Neural Correlates

(2014) V. Skvortsova et al.   JOURNAL OF NEUROSCIENCE

Working Memory Contributions to Reinforcement Learning Impairments in Schizophrenia

(2014) Anne G.E. Collins et al.   JOURNAL OF NEUROSCIENCE

Balancing reward and work: Anticipatory brain activation in NAcc and VTA predict effort differentially

(2014) Nils B. Kroemer et al.   NEUROIMAGE

Structural MRI correlates of apathy symptoms in older persons without dementia: AGES-Reykjavik Study

(2014) A. M. Grool et al.   NEUROLOGY

Dissociable Contributions of Anterior Cingulate Cortex and Basolateral Amygdala on a Rodent Cost/Benefit Decision-Making Task of Cognitive Effort

(2014) Jay G Hosking et al.   NEUROPSYCHOPHARMACOLOGY

The role of serotonin in reward, punishment and behavioural inhibition in humans: Insights from studies with acute tryptophan depletion

(2014) Paul Faulkner et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes

(2014) A. McGirr et al.   PSYCHOLOGICAL MEDICINE

The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study

(2014) Michael A. P. Bloomfield et al.   PSYCHOPHARMACOLOGY

Psychological predictors of functional outcome in people with schizophrenia

(2014) Jacqueline N. Kiwanuka et al.   SCHIZOPHRENIA RESEARCH

The Lille Apathy Rating Scale (LARS): Exploring its psychometric properties in schizophrenia

(2014) Hanan Yazbek et al.   SCHIZOPHRENIA RESEARCH

Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression

(2014) N Lally et al.   Translational Psychiatry

Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil

(2013) Stéphane Thobois et al.   BRAIN

Apathy Secondary to Stroke: A Systematic Review and Meta-Analysis

(2013) Lara Caeiro et al.   CEREBROVASCULAR DISEASES

Negative symptoms of schizophrenia: Clinical features, relevance to real world functioning and specificity versus other CNS disorders

(2013) George Foussias et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Rivastigmine in apathetic but dementia and depression-free patients with Parkinson's disease: a double-blind, placebo-controlled, randomised clinical trial

(2013) D. Devos et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Impulsivity and apathy in Parkinson's disease

(2013) Nihal Sinha et al.   Journal of Neuropsychology

Effort and Valuation in the Brain: The Effects of Anticipation and Execution

(2013) I. T. Kurniawan et al.   JOURNAL OF NEUROSCIENCE

Anhedonia revisited: Is there a role for dopamine-targeting drugs for depression?

(2013) Spilios V Argyropoulos et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Prolonged dopamine signalling in striatum signals proximity and value of distant rewards

(2013) Mark W. Howe et al.   NATURE

Dopamine restores reward prediction errors in old age

(2013) Rumana Chowdhury et al.   NATURE NEUROSCIENCE

A causal link between prediction errors, dopamine neurons and learning

(2013) Elizabeth E Steinberg et al.   NATURE NEUROSCIENCE

The Will to Persevere Induced by Electrical Stimulation of the Human Cingulate Gyrus

(2013) Josef Parvizi et al.   NEURON

Dietary Tyrosine/Phenylalanine Depletion Effects on Behavioral and Brain Signatures of Human Motivational Processing

(2013) James M Bjork et al.   NEUROPSYCHOPHARMACOLOGY

The differing roles of the frontal cortex in fluency tests

(2012) Gail Robinson et al.   BRAIN

Philosophy and the practice of Bayesian statistics

(2012) Andrew Gelman et al.   BRITISH JOURNAL OF MATHEMATICAL & STATISTICAL PSYCHOLOGY

Dopamine reverses reward insensitivity in apathy following globus pallidus lesions

(2012) Robert Adam et al.   CORTEX

Anhedonia and major depression: The role of agomelatine

(2012) Massimo Di Giannantonio et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cytokine effects on the basal ganglia and dopamine function: The subcortical source of inflammatory malaise

(2012) Jennifer C. Felger et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Serotonin Selectively Modulates Reward Value in Human Decision-Making

(2012) B. Seymour et al.   JOURNAL OF NEUROSCIENCE

The Mysterious Motivational Functions of Mesolimbic Dopamine

(2012) John D. Salamone et al.   NEURON

Action controls dopaminergic enhancement of reward representations

(2012) M. Guitart-Masip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural Mechanisms Underlying Motivation of Mental Versus Physical Effort

(2012) Liane Schmidt et al.   PLOS BIOLOGY

Anhedonia in Parkinson's disease: A systematic review of the literature

(2011) Francesca Assogna et al.   MOVEMENT DISORDERS

The relevance of reward pathways for schizophrenia

(2010) Hisham Ziauddeen et al.   CURRENT OPINION IN PSYCHIATRY

Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin

(2010) Y-Lan Boureau et al.   NEUROPSYCHOPHARMACOLOGY

Reward and the serotonergic system

(2010) G.S. Kranz et al.   NEUROSCIENCE

Reconsidering anhedonia in depression: Lessons from translational neuroscience

(2010) Michael T. Treadway et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated Individuals With Major Depressive Disorder

(2009) Diego A. Pizzagalli et al.   AMERICAN JOURNAL OF PSYCHIATRY

Prefrontostriatal Circuitry Regulates Effort-Related Decision Making

(2009) W. Hauber et al.   CEREBRAL CORTEX

Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders

(2009) P. Robert et al.   EUROPEAN PSYCHIATRY

Do people become more apathetic as they grow older? A longitudinal study in healthy individuals

(2009) Henry Brodaty et al.   INTERNATIONAL PSYCHOGERIATRICS

Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease

(2009) S. S. Staekenborg et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Effort-Based Cost-Benefit Valuation and the Human Brain

(2009) P. L. Croxson et al.   JOURNAL OF NEUROSCIENCE

Anhedonia in schizophrenia and major depression: state or trait?

(2009) Lorenzo Pelizza et al.   Annals of General Psychiatry

Incentive motivation in first-episode psychosis: A behavioural study

(2008) Graham K Murray et al.   BMC Psychiatry

Behavioral and Movement Disorders Induced by Local Inhibitory Dysfunction in Primate Striatum

(2008) Yulia Worbe et al.   CEREBRAL CORTEX

The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia

(2008) Helen Lavretsky et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

The nosological position of apathy in clinical practice

(2008) S E Starkstein et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Reward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Functional role of the supplementary and pre-supplementary motor areas

(2008) Parashkev Nachev et al.   NATURE REVIEWS NEUROSCIENCE

Anterior cerebral artery infarction: Stroke mechanism and clinical-imaging study in 100 patients

(2008) S. Y. Kang et al.   NEUROLOGY

Dopamine modulates neural networks involved in effort-based decision-making

(2008) Seyed M. Assadi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Negative Symptoms in Schizophrenia: Avolition and Occam's Razor

(2008) G. Foussias et al.   SCHIZOPHRENIA BULLETIN

Neural Responses to Monetary Incentives in Major Depression

(2007) Brian Knutson et al.   BIOLOGICAL PSYCHIATRY