Article
Biochemistry & Molecular Biology
Junie P. Warrington, Maria Jones-Muhammad, Rachael O. Thompson, Tyranny Pryor, Qingmei Shao, Manasa Gunturu
Summary: Structural changes in the retinal vasculature were observed in multiparous females compared to nulliparous females and male breeders. Multiparous females had higher body mass, heart weight, and kidney weight, while venous pericyte density decreased. The time elapsed since delivery is an important factor to be considered in multiparity studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Scott S. Wildman, Kadeshia Dunn, Justin P. Van Beusecum, Edward W. Inscho, Stephen Kelley, Rebecca J. Lilley, Anthony K. Cook, Kirsti D. Taylor, Claire M. Peppiatt-Wildman
Summary: The presence of a renal GABA/glutamate system has been described, but its functional significance remains unknown. This study demonstrates that activation of endogenous GABA and glutamate receptors significantly alters microvessel diameter in the kidney, suggesting an important role in regulating renal blood flow. The similarity between the effects of GABA and glutamate on renal capillaries and those on central nervous system capillaries implies that targeting the renal GABA/glutamate system could have significant implications for long-term kidney function.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sofia Pereira das Neves, Nickoleta Delivanoglou, Sandro Da Mesquita
Summary: This article discusses the importance and functional characteristics of the lymphatic vascular system found in the meninges of the central nervous system. It also provides an overview of factors affecting meningeal lymphatic function and the role of the lymphatic system in neuroinflammatory diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ethan A. Winkler, Chang N. Kim, Jayden M. Ross, Joseph H. Garcia, Eugene Gil, Irene Oh, Lindsay Q. Chen, David Wu, Joshua S. Catapano, Kunal Raygor, Kazim Narsinh, Helen Kim, Shantel Weinsheimer, Daniel L. Cooke, Brian P. Walcott, Michael T. Lawton, Nalin Gupta, Berislav Zlokovic, Edward F. Chang, Adib A. Abla, Daniel A. Lim, Tomasz J. Nowakowski
Summary: This study constructed a cell atlas of the adult human cerebrovasculature using transcriptomic data of cerebrovascular cells. The cellular and molecular perturbations in brain arteriovenous malformations were investigated, revealing abnormal vascular patterning and inflammation associated with the disease.
Article
Endocrinology & Metabolism
Jillian L. Stobart, Eva Erlebach, Chaim Glueck, Sheng-Fu Huang, Matthew Jp Barrett, Max Li, Sergei A. Vinogradov, Jan Klohs, Yvette Zarb, Annika Keller, Bruno Weber
Summary: This study found that deleting the PDGFB retention motif results in severe pericyte deficiency in the vascular network, leading to reduced cerebral vasodilation capacity and impaired oxygen delivery to the tissue. Pdgfb(ret/ret) mice also showed abnormal blood oxygen extraction, indicating a state of hypoxia. These findings suggest that severe pericyte deficiency can cause vascular abnormalities and altered cerebral blood flow, resembling arteriovenous malformations.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Lauriane Cornuault, Francois-Xavier Herion, Celia Bourguignon, Paul Rouault, Ninon Foussard, Philippe Alzieu, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault
Summary: This study aims to investigate the consequences of partial pericyte depletion in the heart. The results demonstrate that pericyte dysfunction may contribute to the occurrence of cardiac diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Eduardo Benarroch
Summary: Pericytes play a critical role in the neurovascular unit (NVU) by interacting with endothelial cells, basal lamina, and glial cells, contributing to the maintenance of blood-brain barrier stability, regulation of capillary blood flow, angiogenesis, and immune responses. They also possess stem cell properties and can differentiate into smooth muscle, glial cells, or neurons. Dysfunction of pericytes is associated with various neurological disorders, including vascular disorders, Alzheimer's disease, traumatic injury, and multiple sclerosis, highlighting their potential as biomarkers and therapeutic targets for neuroprotection. Extensive reviews have been conducted on the functions and involvement of pericytes in neurological disorders.
Review
Immunology
Ryuichi Nagashima, Masayuki Iyoda
Summary: ILC2s are a recently discovered lymphocyte population with high cytokine productive capacity, especially important in combating helminth infections and allergic tissue inflammation. The cytokine IL-33, released upon tissue damage, may play a role in kidney diseases and fibrosis. Further research is needed to understand the precise contributions of ILC2s to kidney fibrosis and disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xinhong Chen, Damien A. Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F. Shay, Erin E. Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar, Cynthia M. Arokiaraj, Viktor M. Plattner, Lillian J. Campos, John K. Mich, Deja Monet, Victoria Ngo, Xiaozhe Ding, Victoria Omstead, Natalie Weed, Yeme Bishaw, Bryan B. Gore, Ed S. Lein, Athena Akrami, Cory Miller, Boaz P. Levi, Annika Keller, Jonathan T. Ting, Andrew S. Fox, Cagla Eroglu, Viviana Gradinaru
Summary: Efficiently and specifically delivering genes across the brain vasculature remains a challenge for addressing neurological diseases. Researchers have modified adeno-associated virus (AAV9) capsids to transduce brain endothelial cells effectively in mice and rats. These modified AAVs also show superior transduction in non-human primates and ex vivo human brain slices, although the endothelial tropism is not conserved across species. The modified capsids can be used for serotype switching for sequential AAV administration in mice and genetically engineering the blood-brain barrier.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Anna Ioannidou, Rachel M. Fisher, Carolina E. Hagberg
Summary: The vascular endothelial cells in adipose tissue play a crucial role in regulating nutrient uptake and tissue expansibility, affecting the development and function of adipocytes. Understanding the interplay between endothelial cells, adipocytes, and obesity could lead to new therapeutic approaches for obesity-related pathologies.
Review
Nutrition & Dietetics
Sulin F. Kamt, Jiankang Liu, Liang-Jun Yan
Summary: The kidney is a crucial organ functioning in waste elimination and nutrient reabsorption, as well as blood pressure regulation, electrolyte balance, blood pH homeostasis, erythropoiesis, and vitamin D maturation. However, due to its heavy workload and constant exposure to insults, both acute kidney injury (AKI) and chronic kidney disease (CKD) can develop. Unfortunately, there are currently no effective therapeutic managements for AKI or CKD, highlighting the urgent need for novel approaches in treating kidney injury.
Article
Neurosciences
Fabiana Oliveira, Olga Bondareva, Jesus Rafael Rodriguez-Aguilera, Bilal N. Sheikh
Summary: Pericytes are important components of the blood-brain barrier and play critical roles in regulating blood flow and maintaining vascular integrity. In vitro cultured brain pericytes differ transcriptionally from their in vivo counterparts, with cultured cells being more similar to embryonic pericytes than to adult pericytes. Co-culture with brain endothelial cells can improve the expression of pericyte markers and extracellular matrix genes, highlighting the importance of the endothelium in maintaining pericyte identity and function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Yuanhang Yao, Hongyi Manfred Goh, Jung Eun Kim
Summary: This review summarizes the association between dietary carotenoid intake and the risk of cardiovascular diseases, while also outlining the potential roles of carotenoids in protecting against CVDs by attenuating oxidative stress and mitigating inflammatory response. The review emphasizes the importance of bioavailability of carotenoids and suggests dietary strategies to improve their bioavailability when evaluating their roles in CVD protection.
Review
Medicine, Research & Experimental
Rahim Iranzad, Roza Motavalli, Ali Ghassabi, Ramin Pourakbari, Jalal Etemadi, Mehdi Yousefi
Summary: miRNAs play a crucial role in regulating gene expression in kidney diseases, especially in CKD and AKI. Their levels in urine can serve as biomarkers for kidney diseases, and the therapeutic potential of miRNAs is also emphasized.
Article
Biotechnology & Applied Microbiology
Servio H. Ramirez, Jonathan F. Hale, Siobhan McCarthy, Christian L. Cardenas, Kalpani N. Udeni Galpayage Dona, Killian S. Hanlon, Eloise Hudry, Demitri De La Cruz, Carrie Ng, Sabyasachi Das, Diane M. Nguyen, Josette Nammour, Rachel E. Bennett, Allison M. Andrews, Patricia L. Musolino, Casey A. Maguire
Summary: Neurodegeneration and cerebrovascular disease share microvascular dysfunction, which can be remedied by selective transgene delivery. A study characterized an engineered adeno-associated virus (AAV) capsid that effectively targets cerebral vascular pericytes and smooth muscle cells (SMCs). The identified capsid, AAV-PR, showed high transduction of brain vasculature, including pericytes and SMCs, offering the possibility of genetically modulating these cell types in the context of neurodegeneration and other neurological diseases.
HUMAN GENE THERAPY
(2023)
Review
Pharmacology & Pharmacy
Kevin M. Gallagher, Stephen O'neill, Ewen M. Harrison, James A. Ross, Stephen J. Wigmore, Jeremy Hughes
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2017)
Review
Urology & Nephrology
Eoin D. O'Sullivan, Jeremy Hughes, David A. Ferenbach
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2017)
Article
Urology & Nephrology
Boris B. Betz, Sara J. Jenks, Andrew D. Cronshaw, Douglas J. Lamont, Carolynn Cairns, Jonathan R. Manning, Jane Goddard, David J. Webb, John J. Mullins, Jeremy Hughes, Stela McLachlan, Mark W. J. Strachan, Jackie F. Price, Bryan R. Conway
KIDNEY INTERNATIONAL
(2016)
Article
Biochemistry & Molecular Biology
Damian J. Mole, Scott P. Webster, Iain Uings, Xiaozhong Zheng, Margaret Binnie, Kris Wilson, Jonathan P. Hutchinson, Olivier Mirguet, Ann Walker, Benjamin Beaufils, Nicolas Ancellin, Lionel Trottet, Veronique Beneton, Christopher G. Mowat, Martin Wilkinson, Paul Rowlands, Carl Haslam, Andrew McBride, Natalie Z. M. Homer, James E. Baily, Matthew G. F. Sharp, O. James Garden, Jeremy Hughes, Sarah E. M. Howie, Duncan S. Holmes, John Liddle, John P. Iredale
Review
Physiology
David A. D. Munro, Jeremy Hughes
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Hematology
Neill Storrar, Eve Miller-Hodges, John Neary, Jeremy Hughes, Nicole Priddee
AMERICAN JOURNAL OF HEMATOLOGY
(2018)
Article
Immunology
Katie J. Mylonas, Jennifer Anderson, Tara A. Sheldrake, Emily E. Hesketh, James A. Richards, David A. Ferenbach, David C. Kluth, John Savill, Jeremy Hughes
Letter
Urology & Nephrology
Eoin D. O'Sullivan, Katie J. Mylonas, Jeremy Hughes, David A. Ferenbach
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Physiology
James O'Sullivan, Sarah Louise Finnie, Oliver Teenan, Carolynn Cairns, Andrew Boyd, Matthew A. Bailey, Adrian Thomson, Jeremy Hughes, Cecile Benezech, Bryan Ronald Conway, Laura Denby
FRONTIERS IN PHYSIOLOGY
(2019)
Review
Pharmacology & Pharmacy
Marie Helena Docherty, David P. Baird, Jeremy Hughes, David A. Ferenbach
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Urology & Nephrology
Bryan R. Conway, Eoin D. O'Sullivan, Carolynn Cairns, James O'Sullivan, Daniel J. Simpson, Angela Salzano, Katie Connor, Peng Ding, Duncan Humphries, Kevin Stewart, Oliver Teenan, Riinu Pius, Neil C. Henderson, Cecile Benezech, Prakash Ramachandran, David Ferenbach, Jeremy Hughes, Tamir Chandra, Laura Denby
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Medicine, Research & Experimental
Katie L. Connor, Oliver Teenan, Carolynn Cairns, Victoria Banwell, Rachel A. B. Thomas, Julie Rodor, Sarah Finnie, Riinu Pius, Gillian M. Tannahill, Vishal Sahni, Caroline O. S. Savage, Jeremy Hughes, Ewen M. Harrison, Robert B. Henderson, Lorna P. Marson, Bryan R. Conway, Stephen J. Wigmore, Laura Denby
Article
Biochemistry & Molecular Biology
Xiaozhong Zheng, Ailiang Zhang, Margaret Binnie, Kris McGuire, Scott P. Webster, Jeremy Hughes, Sarah E. M. Howie, Damian J. Mole
EXPERIMENTAL AND MOLECULAR MEDICINE
(2019)
Article
Urology & Nephrology
Fiona Duthie, Eoin D. O'Sullivan, Jeremy Hughes
KIDNEY INTERNATIONAL REPORTS
(2016)