Article
Biochemistry & Molecular Biology
Ying-xia Xiong, Nan Li, Miao-miao Han, Fan Ye, Tian Liu, Han-yi Ye, Ting-ting Zheng, Jin-jia Wu, Ying Li, Shaowa Lv, Ying-hua Zhang, Yun Zhang, Zheng-qi Dong
Summary: In this study, Rhodiola rosea polysaccharides (RHPs) were used as an immunoactive vector for hydrophobic drug delivery by chemically modifying folic acid (FA) and stearic acid (SA) to obtain FA-RHPs-SA derivatives. The hydrophobic drug doxorubicin (DOX) was efficiently encapsulated in the FA-RHPs-SA, which exhibited uniform size distribution and pH-sensitive release capacity. Furthermore, the FA-RHPs-SA showed modulatory effects on tumor-associated macrophages and demonstrated superior antitumor activity compared to DOX monotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Rou Xie, Shaobo Ruan, Jiaqi Liu, Lin Qin, Chuanyao Yang, Fan Tong, Ting Lei, Maxim Shevtsov, Huile Gao, Yi Qin
Summary: The study developed a furin-responsive aggregated nanoplatform to address the challenges of insufficient drug accumulation and chemoresistance in cancer chemotherapy. By loading doxorubicin and hydroxychloroquine, the platform enhanced tumor cell sensitivity to chemotherapy drugs and exerted anti-tumor effects through macrophage polarization.
Article
Cell Biology
Makon-Sebastien Njock, Tina O'Grady, Olivier Nivelles, Michelle Lion, Sophie Jacques, Maureen Cambier, Stephanie Herkenne, Florian Muller, Aurelie Christian, Claire Remacle, Julien Guiot, Souad Rahmouni, Franck Dequiedt, Ingrid Struman
Summary: This study found that endothelial cell-derived extracellular vesicles (EVs) participate in the recruitment of macrophages within the tumour in the tumour microenvironment, leading to a change in the immunomodulatory phenotype and promoting tumour growth.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Review
Oncology
Zidi Zhou, Zhilong Yang, Jingzhi Wang, Qiang Wang, Heng Zhang, Xiaoli Ju
Summary: Tumour-associated macrophages (TAMs) play a crucial role in gastric cancer, with their quantity predicting disease progression and metastasis, significantly impacting the treatment and prognosis of patients with gastric cancer.
Article
Biochemistry & Molecular Biology
Zhongwei Li, Pengfei Wang, Wenjie Cui, Hongmei Yong, Diandian Wang, Tiesuo Zhao, Wenwen Wang, Ming Shi, Junnian Zheng, Jin Bai
Summary: The study found that DNMT1 is overexpressed in breast cancer and promotes tumorigenesis and metastasis by activating its expression through ZEB1 and P300, and increasing its expression through the IL-6-pSTAT3-ZEB1-DNMT1 axis in the tumor microenvironment.
CELL AND BIOSCIENCE
(2022)
Review
Cell Biology
Isaure Vanmeerbeek, Jannes Govaerts, Raquel S. Laureano, Jenny Sprooten, Stefan Naulaerts, Daniel M. Borras, Damya Laoui, Massimiliano Mazzone, Jo A. Van Ginderachter, Abhishek D. Garg
Summary: Tumour-associated macrophages (TAMs) play a crucial role in the tumour microenvironment, modulating various pro-tumorigenic and anti-tumorigenic activities, and their interaction with dying cancer cells is important for regulating cancer growth and treatment efficacy.
Review
Cell Biology
Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu, Patrick Ming-Kuen Tang
Summary: Tumour-Associated Macrophages (TAMs) are a key component of the tumour microenvironment, with complex roles in cancer immunity. TAMs can exhibit both pro-tumour and anti-cancer activities. Advanced single-cell technology has revealed novel dedifferentiation phenomena of TAMs. Additionally, TAMs show potential in cancer immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Zhenyu Liu, Jiake Lin, Benke Li, Yuemin Zhou, Chen Li, Yihao Cui, Fengchao Tian, Ruikang Tang, Xiaoyu Wang
Summary: This study presents a method for using manganese-mineralized tumor cells as whole-cell cancer vaccines, which improves the immunogenicity of tumor cells and overcomes immune suppression in solid tumors, leading to effective anti-tumor immune therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Baicheng Wei, Jingmei Pan, Ruiting Yuan, Binfen Shao, Yi Wang, Xing Guo, Shaobing Zhou
Summary: A new cancer treatment strategy has been developed, where tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapy drugs can significantly enhance the efficacy of immunotherapy.
Article
Endocrinology & Metabolism
Yu Wang, Muhan Xu, Jian Sun, Xiaoxiao Li, Huazheng Shi, Xuefeng Wang, Benming Liu, Tao Zhang, Xu Jiang, Liangyu Lin, Qing Li, Yin Huang, Yong Liang, Mingyuan Hu, Fanjun Zheng, Fengyu Zhang, Jian Sun, Yufang Shi, Ying Wang
Summary: In this study, the researchers investigate how interactions between neutrophils and T cells in lymphoid tissues away from the tumour area, as well as metabolic competition between these immune cell populations, impair anti-tumour immunity in breast cancer. They found that the spleens of both humans and mice with breast cancer undergo metabolic reprogramming to a glycolytic state, which influences the microenvironment and negatively affects T cell responses. They also discovered that the CCL9 chemokine produced by splenic stromal cells is crucial for neutrophil accumulation, and blocking the CCR1 receptor promotes tumour eradication.
Article
Oncology
Zijian Wang, Zhixiang Du, Haoyu Sheng, Xiuliang Xu, Wenjie Wang, Jian Yang, Jian Sun, Jianghua Yang
Summary: Schistosomal CRC and non-schistosomal CRC patients exhibit different clinicopathological features and prognosis, with schistosomiasis being a risk factor for CRC and M2 TAMs serving as independent prognostic factors for OS.
Review
Pharmacology & Pharmacy
Yuanyuan He, Raimundo Fernandes de Araujo Jr, Luis J. Cruz, Christina Eich
Summary: The tumor microenvironment is crucial in regulating antitumor immune responses, with a focus on M2 macrophages. Immunotherapy approaches targeting tumor-associated macrophages aim to reduce the immunosuppressive state, however, facing limitations such as drug degradation rate and cytotoxicity. Nanomedicine formulations offer promising strategies in cancer therapy by specifically targeting M2 TAMs, reducing side effects and enhancing therapeutic potential.
Article
Pharmacology & Pharmacy
Romulo S. Cavalcante, Uta Ishikawa, Emanuell S. Silva, Arnobio A. Silva-Junior, Aurigena A. Araujo, Luis J. Cruz, Alan B. Chan, Raimundo F. de Araujo Junior
Summary: The study developed a methotrexate-loaded nanocarrier combined with a PD-L1 antibody to modulate the immune response in breast cancer TME, leading to reduction of primary tumor size and metastases.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Jimin Guo, Henning De May, Stefan Franco, Achraf Noureddine, Lien Tang, C. J. Brinker, Donna F. Kusewitt, Sarah F. Adams, Rita E. Serda
Summary: Efficient cancer vaccines can be created by cryogenic silicification of tumor cells followed by decorating the surface with pathogen-related molecular patterns, leading to activation of dendritic cells and enhanced T cell immune responses against tumor antigens.
NATURE BIOMEDICAL ENGINEERING
(2022)