Article
Biochemistry & Molecular Biology
Hongping Chen, Lihui Zhang, Shaohua Mi, Hua Wang, Chunxiao Wang, Wenjuan Jia, Lei Gong, Haibin Dong, Bowen Xu, Yanyan Jing, Peipei Ge, Zhigang Pei, Lin Zhong, Jun Yang
Summary: This study aimed to investigate the effect of FURIN on atherosclerosis (AS) progression through autophagy. FURIN expression and autophagy levels were found to be elevated in atherosclerotic plaques of aortic tissues from patients. In macrophages, FURIN overexpression promoted autophagy and decreased lipid droplet concentrations. Furthermore, FURIN regulated autophagy through the AMPK/mTOR/ULK1/PI3KIII signaling pathway. In vivo experiments using ApoE-/- mice confirmed that FURIN could inhibit AS progression by promoting macrophage autophagy.
Article
Oncology
Kai Zhang, Jing Chen, Chen Li, Surong Fang, Wenfei Liu, Yingying Qian, Jiyong Ma, Ligong Chang, Feifei Chen, Zhenhua Yang, Wei Gu
Summary: In this study, we found that SNHG7 enhances docetaxel resistance of LUAD cells by inducing autophagy and macrophage M2 polarization. Exosomal SNHG7 transmitted between cells plays a crucial role in facilitating docetaxel resistance, indicating a potential target for overcoming resistance in LUAD.
Article
Gastroenterology & Hepatology
Honglin Jiang, Tristan Courau, Joseph Borison, Alexa J. Ritchie, Aaron T. Mayer, Matthew F. Krummel, Eric A. Collisson
Summary: MEK and autophagy co-inhibition coupled with CD40 agonism activates the STING/type I interferon pathway and enhances immunogenicity of tumor-associated macrophages in pancreatic ductal adenocarcinoma (PDA) cells. This treatment strategy achieves cytotoxic T-cell activation and enhances antitumor immunity in an immunologically cold mouse PDA model.
Article
Biochemistry & Molecular Biology
Ying Cao, Weili Mai, Rui Li, Shuwei Deng, Lan Li, Yanxi Zhou, Qiushi Qin, Yue Zhang, Xingang Zhou, Ming Han, Pu Liang, Yonghong Yan, Yu Hao, Wen Xie, Jie Yan, Liuluan Zhu
Summary: The study found that in the progression of nonalcoholic fatty liver disease, liver macrophages polarized towards M2 type and promoted HSC autophagy by secreting PGE2, worsening liver fibrosis. The PGE2/EP4 pathway may be a promising therapeutic target to prevent NASH progression into cirrhosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Immunology
Jun-Hao Wen, Dong-Yi Li, Shan Liang, Chen Yang, Ji-Xin Tang, Hua-Feng Liu
Summary: This article summarizes the role of macrophages in organ fibrosis and the importance of autophagy in maintaining macrophage homeostasis. It discusses the heterogeneity of macrophages in different organs and highlights the potential of macrophage autophagy in fibrosis treatment. The article also briefly discusses important unresolved issues in this field.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xinxin Zhang, Yating Qin, Xiaoning Wan, Hao Liu, Chao Lv, Weibin Ruan, Lin He, Li Lu, Xiaomei Guo
Summary: The study showed that RVS treatment reduced plaque areas in the aorta inner surface and the aortic sinus of ApoE(-/-) mice with high-fat diet, improved lipid profiles, and reduced contents of inflammatory cytokines. These effects of RVS were attributed to the activation of autophagy cascades and promotion of cholesterol efflux and M2 macrophage polarization.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Agriculture, Multidisciplinary
Xue-Ying Li, Yu-Jing Wang, Shun Chen, Li-Hua Pan, Qiang-Ming Li, Jian-Ping Luo, Xue-Qiang Zha
Summary: The present study demonstrated that LJP61A significantly reduced the lesion burden in atherosclerotic mice and alleviated lipid deposition in Ox-LDL-stimulated macrophages. Moreover, LJP61A enhanced autophagy-mediated macrophage polarization, leading to reduced inflammation and atherosclerosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Xuemei Hu, Yueyue Li, Qingyang Chen, Tingting Wang, Limei Ma, Wanping Zhang, Ruihong Yu, Jun Zhang, Jingyuan Wan, Chao Yu, Zhiyi Yuan
Summary: Accumulating evidence suggests that sialic acids play a crucial role in the development of atherosclerosis, but the specific effects and mechanisms have not been fully defined. This study demonstrates that sialic acids can promote the polarization of macrophages to the proinflammatory M1 phenotype, leading to the expression of proinflammatory cytokines. This proinflammatory effect is likely due to the inhibition of the LKB1-AMPK-Sirt3 signaling pathway, resulting in increased intracellular ROS levels and impaired autophagy-lysosome system, ultimately exacerbating atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Toxicology
Balasubramanyam Annangi, Zhuyi Lu, Jonathan Bruniaux, Audrey Ridoux, Vanessa Marques da Silva, Delphine Vantelon, Jorge Boczkowski, Sophie Lanone
Summary: Exposure to CeO2 NP in mice induces progressive and dose-dependent lung fibrosis in bronchiolar and alveolar walls, accompanied by autophagy activation. Inhibition of macrophagic autophagy provides protection against alveolar fibrosis, by modulating macrophage polarization towards M2 phenotype.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Fisheries
W. A. D. L. R. Warnakula, H. M. V. Udayantha, D. S. Liyanage, W. K. M. Omeka, Chaehyeon Lim, Gaeun Kim, D. M. K. P. Sirisena, B. P. M. Vileka Jayamali, Qiang Wan, Jehee Lee
Summary: This study demonstrates for the first time that PhGal9 promotes M2 macrophage polarization and prevents VHSV attachment and replication by neutralizing virion and autophagy in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Tao Liu, Liqiu Wang, Puping Liang, Xiaojuan Wang, Yukun Liu, Jing Cai, Yuanchu She, Dan Wang, Zhi Wang, Zhiyong Guo, Samuel Bates, Xiaojun Xia, Junjiu Huang, Jun Cui
Summary: The study reveals that USP19 acts as an anti-inflammatory switch promoting M2-like macrophage polarization and inhibiting inflammatory responses by affecting NLRP3 activity through various mechanisms.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Chen Chen, Jianan Ma, Chenchen Pi, Wei Huang, Tao Zhang, Cong Fu, Wentao Liu, Yong-Guang Yang
Summary: IL-10(+) regulatory B cells (Bregs) are important in cancer immunotherapy with PPAR delta playing a significant role in their development and function. In this study, PPAR delta was found to be upregulated in tumor-induced IL-10(+) Bregs, and its expression level was correlated with IL-10 production and T cell inhibition. Genetic inactivation of PPAR delta impaired IL-10(+) Breg development and function, while treatment with a PPAR delta inhibitor reduced their induction. Immunotherapy with CD40 or PD1 antibodies had improved outcomes in tumor-bearing mice with PPAR delta deficiency or treated with a PPAR delta inhibitor.
Article
Biochemistry & Molecular Biology
Changyun Yu, Binbin Xue, Jinying Li, Qianqian Zhang
Summary: This study aimed to investigate the role and regulatory mechanism of RNF126 in nasopharyngeal carcinoma. The results showed that tumor-derived exosomal PTEN degrades PTEN through ubiquitination to regulate the tumor immune microenvironment and promote NPC growth and metastasis.
Article
Oncology
Balawant Kumar, Rizwan Ahmad, Swagat Sharma, Saiprasad Gowrikumar, Mark Primeaux, Sandeep Rana, Amarnath Natarajan, David Oupicky, Corey R. Hopkins, Punita Dhawan, Amar B. Singh
Summary: Colorectal cancer (CRC) therapy faces challenges due to cancer stem cells (CSCs) resistance to chemotherapy. Inhibiting autophagy with 36-077, a potent PIK3C3/VPS34 inhibitor, shows promise in improving the efficacy of CRC therapy by targeting CSCs.
Article
Cell Biology
Kun Yi, Yuping Yang, Ye Yuan, Yingqian Xiang, Shanbi Zhou
Summary: The study found that impairment of autophagy promotes macrophage polarization towards the M1 type, increases the expression of IL-6 and TNF-alpha, leading to severe CNV. However, the use of autophagy activator RAPA can effectively alleviate CNV.
Article
Chemistry, Multidisciplinary
Mingming Han, Jingjing Yao, Jiwu Huang, Yan Tang, Xianwen Wu, Bingan Lu, Jiang Zhou
Summary: Aqueous rechargeable Zn//MnO2 batteries are a promising candidate for future energy storage systems due to their economic and environmental advantages. However, poor reaction kinetics and capacity degradation hinder the performance of Zn//MnO2 batteries. This study demonstrates that defects engineering and phase transformation can enhance ion/charge transfer kinetics and structural stability, leading to a high discharge capacity of 285 mAh/g and capacity retention of 81% after 500 cycles in the aqueous Zn//A-MnO2 system.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Rui Liu, Cong Luo, Zhiqing Pang, Jinming Zhang, Shaobo Ruan, Meiying Wu, Lei Wang, Tao Sun, Nan Li, Liang Han, Jinjin Shi, Yuanyu Huang, Weisheng Guo, Shaojun Peng, Wenhu Zhou, Huile Gao
Summary: Decades have passed since the approval of the first nanoparticles-based medicine for human cancer treatment, and research and development in nanoparticles for drug delivery have been continuing. Today, there have been significant advancements in nanoparticles, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines, and nano-antibodies. These nanoparticles have shown great potential in the treatment and diagnosis of challenging diseases such as cancer and neurodegenerative diseases, making them promising drug carriers and therapeutic agents in the future.
CHINESE CHEMICAL LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Shaobo Ruan, Yuanyu Huang, Mei He, Huile Gao
Summary: The past decade has seen significant advancements in cancer immunotherapy, but there are still limitations that need to be addressed. Functional biomaterials offer a solution by providing cell-specific modulation of cancer immunotherapy, improving treatment efficacy and reducing side effects. This review focuses on how biomaterials can be used to target specific cells involved in the cancer-immune cycle for personalized cancer immunotherapy, and discusses current challenges and future perspectives.
Article
Chemistry, Multidisciplinary
Xueqin He, Jiang Xie, Jing Zhang, Xiaorong Wang, Xufeng Jia, Heng Yin, Zhongqing Qiu, Zhihang Yang, Jiao Chen, Zhiliang Ji, Wenqi Yu, Meiwan Chen, Wenming Xu, Huile Gao
Summary: This study established an aspirin encapsulated cascade drug delivery system (Asp@TMNPs) that targets the blood-brain barrier and microglial cells, effectively alleviating mitochondrial oxidative stress, DNA damage, and inflammation in microglial cells. After treatment with Asp@TMNPs, social interaction, stereotype behavior, and anxious condition in ASD mice were notably improved, and microglial cell activation was inhibited.
Review
Biochemistry & Molecular Biology
Sergey Tsymbal, Ge Li, Nikol Agadzhanian, Yuhao Sun, Jiazhennan Zhang, Marina Dukhinova, Viacheslav Fedorov, Maxim Shevtsov
Summary: The treatment of drug-resistant cancer forms requires consideration of their unique characteristics such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways. Copper metabolism is particularly important in cancer cells due to its role in maintaining cellular oxidation levels, regulating protein activity, and involvement in inflammation. Preclinical studies have shown that copper-based compounds exhibit specific activity against cancer cells and have the potential for the development of novel cancer therapeutics.
Article
Pharmacology & Pharmacy
Zhihang Yang, Yufan Du, Lei Lei, Xue Xia, Xiaorong Wang, Fan Tong, Yuan Li, Huile Gao
Summary: In this study, a human serum albumin-based co-delivery system of IBR and HCQ was developed for the treatment of glioma. The system improved the bioavailability of IBR, enhanced the sensitivity of glioma to IBR, and inhibited the prosurvival autophagy induced by IBR through HCQ. The in vitro and in vivo experiments demonstrated the cytotoxicity and prolonged survival time of IBR&HCQ HSA NPs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biotechnology & Applied Microbiology
Natalia Yudintceva, Natalia Mikhailova, Viacheslav Fedorov, Konstantin Samochernych, Tatiana Vinogradova, Alexandr Muraviov, Maxim Shevtsov
Summary: This review summarizes the scientific data on the applications of mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) in the combined treatment of infectious diseases. The study found that MSCs and MSC-EVs have immunomodulatory, anti-inflammatory, and antibacterial effects in the treatment of infectious diseases, and also promote tissue regeneration. The use of MSC-EVs is a promising cell-free treatment strategy that improves the safety and effectiveness of cell therapy.
BIOENGINEERING-BASEL
(2022)
Review
Chemistry, Multidisciplinary
Kamil Gareev, Ruslana Tagaeva, Danila Bobkov, Natalia Yudintceva, Daria Goncharova, Stephanie E. Combs, Artem Ten, Konstantin Samochernych, Maxim Shevtsov
Summary: Nanocarriers have shown potential in translational oncology, but their practical application in living organisms is hindered by physiological barriers. This review focuses on approaches to enhance the translocation of nanoparticles across blood-tissue barriers and accumulate in tumors. These approaches include the functionalization of particle surfaces with cell-penetrating peptides and the use of chemical agents or physical methods to increase barrier permeability.
Article
Chemistry, Multidisciplinary
Vyacheslav Ryzhov, Vladimir Deriglazov, Denis Grouzdev, Veronika Koziaeva, Igor Kiselev, Ivan Larionov, Kamil Gareev, Nikita Sitkov, Tatiana Zimina, Yaroslav Marchenko, Maxim Shevtsov
Summary: The magnetic parameters of magnetosomes inside bacteria of different strains were studied. The samples were stored for different lengths of time and analyzed using various spectroscopic techniques. The results showed the presence of magnetosomes with different magnetic properties and variations in the spectral peaks between new and old samples.
APPLIED SCIENCES-BASEL
(2023)
Review
Pharmacology & Pharmacy
Boris Nikolaev, Ludmila Yakovleva, Viacheslav Fedorov, Hanmei Li, Huile Gao, Maxim Shevtsov
Summary: Nano- and microemulsions, colloidal systems widely used in biomedicine, have important applications in various fields such as wound healing, cosmetology, drug development, and oncology. The stability of these systems depends on the balance of molecular interactions between nanodomains. Microemulsions, as a colloidal form, play a crucial role in stability due to their thermodynamic stability and low surface energy. This review examines the theory, methods of obtaining, and structure analysis of nano- and microemulsions. It also summarizes the main studies in wound healing and cancer therapy using emulsions, highlighting future prospects in this area.
Article
Pathology
Samvel Tonyan, Maria Pospelova, Varvara Krasnikova, Olga Fionik, Tatyana Alekseeva, Konstantin Samochernykh, Nataliya Ivanova, Tatyana Vavilova, Elena Vasilieva, Albina Makhanova, Aleksandra Nikolaeva, Tatyana Bukkieva, Stephanie Combs, Maxim Shevtsov
Summary: Peripheral nervous system (PNS) damage is a common complication of breast cancer (BC) treatment, affecting 60-80% of survivors. This study measured the levels of brain-derived neurotrophic factor (BDNF), galectin-3 (Gal-3), and neurotrophin-3 (NT-3) in the blood serum of BC patients to investigate their potential as biomarkers for PNS damage. The results showed that NT-3 levels were significantly higher in BC patients compared to healthy volunteers, suggesting NT-3 could be a potential biomarker for PNS damage in BC patients.
Article
Pathology
Alexandra Nikolaeva, Maria Pospelova, Varvara Krasnikova, Albina Makhanova, Samvel Tonyan, Yurii Krasnopeev, Evgeniya Kayumova, Elena Vasilieva, Aleksandr Efimtsev, Anatoliy Levchuk, Gennadiy Trufanov, Mark Voynov, Maxim Shevtsov
Summary: Vestibulo-atactic syndrome (VAS), a complication of breast cancer treatment, significantly impacts patients' quality of life. This study found that the levels of ICAM-1, PECAM-1, NSE, and NR-2-ab in the blood serum of VAS patients were associated with brain connectome data obtained from fMRI studies. The elevated biomarker levels indicate damage to CNS neurons and endothelial cells, which is related to changes in brain connectivity in this group of patients.
Article
Pharmacology & Pharmacy
Tina Sepasi, Farhad Bani, Reza Rahbarghazi, Abbas Ebrahimi-Kalan, Mohammad-Reza Sadeghi, Seyedeh Zahra Alamolhoda, Amir Zarebkohan, Tahereh Ghadiri, Huile Gao
Summary: This study successfully designed an efficient biocarrier for brain gene delivery using CDX-modified chitosan nanoparticles, leading to the expression of the target protein. However, these nanoparticles also showed distribution in other organs.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
